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AMR Drug RepurposingSmart Screeningresearch prototype

Cetrorelix Acetate

FDA-approved product (powder, subcutaneous), marketed as Cetrorelix Acetate, Cetrotide.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cetrorelix Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Ovulation Inhibition
  • Positive regulation of ovulation

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Anti-gonadotropin-releasing hormones
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA63.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae28.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis62.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cetrorelix Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cetrorelix Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • The Comparison of Effect of Four Different Treatment Protocols on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization.

    NCT01948804 · start 2014-01

    Registered record
    Registry ID
    NCT01948804
    Conditions
    Poor Responders Undergoing IVF
    Interventions
    GnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG); microdose flare-up protocol (Lucrin; Abbott + Gonal F, Serono); Antagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma); GnRH antagonist protocol (Cetrotide, Serono)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-01
    Completion
    Not recorded
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPoor Responders Undergoing IVF
    InterventionGnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG); microdose flare-up protocol (Lucrin +4 more
    PhasePhase 4
    Registry statusUnknown

  • Endometrial Injury and IVF Outcome Parameters in Patients With Failed IVF Cycles

    NCT01798862 · start 2013-03

    Registered record
    Registry ID
    NCT01798862
    Conditions
    Repeated Implantation Failures
    Interventions
    Endometrial injury by hysteroscopy or pipelle sampling; Proceed to COH directly
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2013-03
    Completion
    2016-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRepeated Implantation Failures
    InterventionEndometrial injury by hysteroscopy or pipelle sampling; Proceed to COH directly
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Use of Degarelix in Controlled Ovarian Hyperstimulation (COH) Protocol for Women With PoliCystic Ovarian Syndrome (PCOS)

    NCT01709942 · start 2012-11

    Registered record
    Registry ID
    NCT01709942
    Conditions
    PCOS; OHSS; INFERTILITY
    Interventions
    degarelix (long acting GnRH antagonist); cetrorelix 0.25mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-11
    Completion
    2015-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPCOS; OHSS; INFERTILITY
    Interventiondegarelix (long acting GnRH antagonist); cetrorelix 0.25mg
    PhasePhase 3
    Registry statusCompleted

  • Comparing Ovarian Stimulation for Assisted Reproduction With Two Different Forms of Pituitary Suppression

    NCT01565265 · start 2012-04

    Registered record
    Registry ID
    NCT01565265
    Conditions
    Female Infertility Due to Nonimplantation of Ovum; Complications Associated With Artificial Fertilization
    Interventions
    Pergoveris in long protocol with GnRH agonist; Pergoveris in GnRH antagonist protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-04
    Completion
    2013-12
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFemale Infertility Due to Nonimplantation of Ovum; Complications Associated With Artificial Fertilization
    InterventionPergoveris in long protocol with GnRH agonist; Pergoveris in GnRH antagonist protocol
    PhaseNot applicable
    Registry statusCompleted

  • Study on Influence of Leutinizing Hormone (LH) on Oocyte Maturity

    NCT01595334 · start 2012-04

    Registered record
    Registry ID
    NCT01595334
    Conditions
    Infertility
    Interventions
    Cetrorelix; Luprolide Acetate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2012-04
    Completion
    2012-11
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionCetrorelix; Luprolide Acetate
    PhaseNot applicable
    Registry statusUnknown

  • Addition of Prednisolone and Heparin in Patients Undergoing IVF With Failed IVF Cycles

    NCT01590173 · start 2012-01

    Registered record
    Registry ID
    NCT01590173
    Conditions
    Infertility
    Interventions
    Prednisolone and Heparin during COH for IVF; COH for IVF
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2012-01
    Completion
    2016-07
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionPrednisolone and Heparin during COH for IVF; COH for IVF
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Synchronization of Ovarian Stimulation for in Vitro Fertilization With Follicular Wave Emergence

    NCT01668056 · start 2012-01

    Registered record
    Registry ID
    NCT01668056
    Conditions
    Infertility
    Interventions
    Ovulation induction with choriogonadotropin alfa; Aspiration of the dominant follicle; Control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2012-01
    Completion
    2014-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionOvulation induction with choriogonadotropin alfa; Aspiration of the dominant follicle; Control
    PhaseNot applicable
    Registry statusUnknown

  • Gonadotropin Type in Ovarian Stimulation

    NCT02437032 · start 2009-04

    Registered record
    Registry ID
    NCT02437032
    Conditions
    Infertility
    Interventions
    recombinant FSH; Urinary FSH; hMG
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-04
    Completion
    2012-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    Interventionrecombinant FSH; Urinary FSH; hMG
    PhasePhase 4
    Registry statusCompleted

  • The Role of Cetrotide Acetate in Prevention of Ovarian Hyperstimulation Syndrome (OHSS) in Oocyte Donors

    NCT00867659 · start 2009-03

    Registered record
    Registry ID
    NCT00867659
    Conditions
    Ovarian Hyperstimulation Syndrome
    Interventions
    Cetrotide acetate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-03
    Completion
    2011-10
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Hyperstimulation Syndrome
    InterventionCetrotide acetate
    PhaseNot applicable
    Registry statusCompleted

  • Extended High Dose Letrozole Regimen Versus Short Low Dose Letrozole Regimen as an Adjuvant to GnRH Antagonist Protocol in the Management of Poor Responders Undergoing IVF-ET

    NCT01219153 · start 2008-09

    Registered record
    Registry ID
    NCT01219153
    Conditions
    Infertility
    Interventions
    Extended high dose letrozole regimen /GnRH antagonist protocol; Short low dose letrozole regimen /GnRH antagonist protocol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-09
    Completion
    2010-12
    Enrolment
    136

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionExtended high dose letrozole regimen /GnRH antagonist protocol; Short low dose letrozole regimen /GnRH antagonist protocol
    PhasePhase 2
    Registry statusCompleted

  • Cetrorelix Pamoate IM Regimens in Patients With Symptomatic Benign Prostatic Hyperplasia (BPH)

    NCT00670306 · start 2008-03

    Registered record
    Registry ID
    NCT00670306
    Conditions
    Benign Prostatic Hypertrophy
    Interventions
    Cetrorelix Pamoate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2009-08
    Enrolment
    528

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hypertrophy
    InterventionCetrorelix Pamoate
    PhasePhase 3
    Registry statusCompleted

  • Gonadotropin-releasing Hormone Antagonist on Triggering Day: A Randomized Controlled Study

    NCT00571870 · start 2007-11

    Registered record
    Registry ID
    NCT00571870
    Conditions
    Infertility
    Interventions
    cetrorelix acetate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-11
    Completion
    2009-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    Interventioncetrorelix acetate
    PhaseNot applicable
    Registry statusCompleted

  • A Phase II Study to Assess the Efficacy and Safety of Luveris® (Lutropin Alfa) in Mid Follicular Phase for Controlled Ovarian Stimulation (COS) in Advanced Reproductive Age

    NCT01079949 · start 2007-11

    Registered record
    Registry ID
    NCT01079949
    Conditions
    Infertility; Ovulation Induction
    Interventions
    r-hLH + r-hFSH; r-hFSH; Recombinant Human Choriogonadotropin (r-hCG); GnRH antagonist
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2007-11
    Completion
    2010-10
    Enrolment
    93

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility; Ovulation Induction
    Interventionr-hLH + r-hFSH; r-hFSH; Recombinant Human Choriogonadotropin (r-hCG); GnRH antagonist
    PhasePhase 2
    Registry statusTerminated

  • Synchronization of Follicle Wave Emergence and Ovarian Stimulation

    NCT00439829 · start 2007-02

    Registered record
    Registry ID
    NCT00439829
    Conditions
    Infertility
    Interventions
    Gonal F; Luveris; Cetrotide; hCG
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-02
    Completion
    2010-05
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionGonal F; Luveris; Cetrotide; hCG
    PhasePhase 4
    Registry statusCompleted

  • GnRH Antagonist to Prepare Recipients for Embryo Transfer

    NCT00460642 · start 2007-01

    Registered record
    Registry ID
    NCT00460642
    Conditions
    Infertility
    Interventions
    GnRH Antagonist (Cetrotide)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-01
    Completion
    2009-12
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionGnRH Antagonist (Cetrotide)
    PhaseNot applicable
    Registry statusCompleted