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AMR Drug RepurposingSmart Screeningresearch prototype

Temazepam

FDA-approved product (capsule, oral), marketed as Restoril, Temaz, Temazepam.

Registered studies
12
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Temazepam
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Insomnia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Benzodiazepine derivatives
FDA pharmacologic class
Benzodiazepine FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli30.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae25.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

12registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Temazepam in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-5.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Temazepam with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Wholetones® 2Sleep Music on Health and Sleep Behaviors of Healthy Adults With Insomnia Symptoms

    NCT03928301 · start 2019-01-15

    Registered record
    Registry ID
    NCT03928301
    Conditions
    Insomnia; Sleeplessness
    Interventions
    Wholetones Music; Classical Music
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-01-15
    Completion
    2019-03-12
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia; Sleeplessness
    InterventionWholetones Music; Classical Music
    PhaseNot applicable
    Registry statusCompleted

  • Brainstem Dysfunction Involvement in the Pathogenesis of Pierre Robin Sequence

    NCT03423017 · start 2018-05-24

    Registered record
    Registry ID
    NCT03423017
    Conditions
    Pierre Robin Sequence; Brainstem Dysfunction
    Interventions
    Recording of data; Recording of data
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-05-24
    Completion
    2023-03-23
    Enrolment
    113

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPierre Robin Sequence; Brainstem Dysfunction
    InterventionRecording of data; Recording of data
    PhaseNot applicable
    Registry statusCompleted

  • A Safety and Immunogenicity Study in Long-term Treatment of Eculizumab (JSC "GENERIUM", Russian Federation)

    NCT04679103 · start 2018-05-03

    Registered record
    Registry ID
    NCT04679103
    Conditions
    Paroxysmal Nocturnal Hemoglobinuria
    Interventions
    Eculizumab (JSC GENERIUM, Russia)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-05-03
    Completion
    2020-04-20
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParoxysmal Nocturnal Hemoglobinuria
    InterventionEculizumab (JSC GENERIUM, Russia)
    PhasePhase 3
    Registry statusCompleted

  • Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal Irritations

    NCT02558738 · start 2015-06-22

    Registered record
    Registry ID
    NCT02558738
    Conditions
    Pruritus; Dermatitis; Otitis Externa
    Interventions
    ear spray
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-06-22
    Completion
    2015-09
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPruritus; Dermatitis; Otitis Externa
    Interventionear spray
    PhaseNot recorded
    Registry statusCompleted

  • Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Replacement.

    NCT02288923 · start 2015-03

    Registered record
    Registry ID
    NCT02288923
    Conditions
    Arthritis Knee
    Interventions
    Femoral nerve block; Local Infiltration Analgesia; Sub arachnoid analgesia; Sedation or general anaesthesia; Pre-medication; Intra-operative medication; Post-operative analgesia - morphine; Post-operative analgesia - ibuprofen and paracetamol; Regular anti emetics
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-03
    Completion
    2018-07-01
    Enrolment
    199

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthritis Knee
    InterventionFemoral nerve block; Local Infiltration Analgesia; Sub arachnoid analgesia; Sedation or general anaesthesia +5 more
    PhaseNot applicable
    Registry statusCompleted

  • Pharmacovigilance in Gerontopsychiatric Patients

    NCT02374567 · start 2015-01

    Registered record
    Registry ID
    NCT02374567
    Conditions
    Dementia; Depression; Schizophrenia; Psychosomatic Disorders; Anxiety Disorders
    Interventions
    Phenobarbital; Phenytoin; Carbamazepine; Oxcarbazepine; Valproic Acid; Lamotrigine; Topiramate; Gabapentin; Levetiracetam; Pregabalin; Lacosamide; Clonazepam; Biperiden; Levomepromazine; Fluphenazine; Perphenazine; Perazine; Thioridazine; Haloperidol; Melperone; Pipamperone; Bromperidol; Benperidol; Sertindole; Ziprasidone; Flupentixol; Chlorprothixene; Zuclopenthixol; Fluspirilene; Pimozide; Clozapine; Olanzapine; Quetiapine; Sulpiride; Tiapride; Amisulpride; Prothipendyl; Risperidone; Aripiprazole; Paliperidone; Diazepam; Oxazepam; Lorazepam; Bromazepam; Clobazam; Alprazolam; Hydroxyzine; Buspirone; Chloral Hydrate; Flurazepam; Nitrazepam; Triazolam; Lormetazepam; Temazepam; Midazolam; Brotizolam; Zopiclone; Zolpidem; Zaleplon; Melatonin; Clomethiazole; Diphenhydramine; Promethazine; Imipramine; Clomipramine; Opipramol; Trimipramine; Amitriptyline; Nortriptyline; Doxepin; Maprotiline; Amitriptyline oxide; Fluoxetine; Citalopram; Paroxetine; Sertraline; Fluvoxamine; Escitalopram; Tran
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-01
    Completion
    2017-06-28
    Enrolment
    407

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDementia; Depression; Schizophrenia; Psychosomatic Disorders +1 more
    InterventionPhenobarbital; Phenytoin; Carbamazepine; Oxcarbazepine +75 more
    PhasePhase 3
    Registry statusTerminated

  • Effects of Hallucinogens and Other Drugs on Mood and Performance

    NCT02033707 · start 2014-04

    Registered record
    Registry ID
    NCT02033707
    Conditions
    Healthy
    Interventions
    Hallucinogens and psychoactive substances
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-04
    Completion
    2019-02
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionHallucinogens and psychoactive substances
    PhasePhase 1
    Registry statusCompleted

  • Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude

    NCT01519544 · start 2012-03

    Registered record
    Registry ID
    NCT01519544
    Conditions
    High-altitude Sleep Disturbance
    Interventions
    Temazepam; Acetazolamide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-03
    Completion
    2015-03
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh-altitude Sleep Disturbance
    InterventionTemazepam; Acetazolamide
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy and Safety of Temazepam in HIV Seropositive Patients With Insomnia

    NCT02153788 · start 2009-09

    Registered record
    Registry ID
    NCT02153788
    Conditions
    Insomnia
    Interventions
    Temazepam; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-09
    Completion
    Not recorded
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia
    InterventionTemazepam; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Study to Investigate the Effects of Melatonin, Temazepam & Zolpidem on Sleep EEG in Men and Women

    NCT00940550 · start 2009-07

    Registered record
    Registry ID
    NCT00940550
    Conditions
    Insomnia
    Interventions
    Prolonged-release melatonin; Temazepam; Zolpidem; Placebo to match melatonin, zolpidem and temazepam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-07
    Completion
    2009-08
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia
    InterventionProlonged-release melatonin; Temazepam; Zolpidem; Placebo to match melatonin, zolpidem and temazepam
    PhasePhase 1
    Registry statusCompleted

  • The Treatment of Insomnia in Patients With HIV Disease

    NCT00465972 · start 2007-03

    Registered record
    Registry ID
    NCT00465972
    Conditions
    HIV Infections; Insomnia
    Interventions
    Doxepin; Temazepam; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-03
    Completion
    2010-08
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Insomnia
    InterventionDoxepin; Temazepam; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Effects of Temazepam in Patients With Chronic Pulmonary Obstructive Disease

    NCT00245661 · start 2005-10

    Registered record
    Registry ID
    NCT00245661
    Conditions
    Chronic Obstructive Pulmonary Disease
    Interventions
    Temazepam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-10
    Completion
    2007-08
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease
    InterventionTemazepam
    PhasePhase 3
    Registry statusCompleted