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AMR Drug RepurposingSmart Screeningresearch prototype

Aminocaproic Acid

FDA-approved product (tablet, oral), marketed as Amicar, Aminocaproic, Aminocaproic Acid and 1 more.

Registered studies
36
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Aminocaproic Acid
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Amino acids
FDA pharmacologic class
Antifibrinolytic Agent FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Aminocaproic Acid, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA17.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli8.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae19.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis15.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

36registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Aminocaproic Acid in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Aminocaproic Acid with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Amicar for Children Having Craniofacial Surgery

    NCT02229968 · start 2014-10

    Registered record
    Registry ID
    NCT02229968
    Conditions
    Craniosynostosis
    Interventions
    Amicar (ε-aminocaproic acid); normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2014-10
    Completion
    2028-03
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCraniosynostosis
    InterventionAmicar (ε-aminocaproic acid); normal saline
    PhasePhase 2
    Registry statusActive not recruiting

  • PRevention Of BLeeding in hEmatological Malignancies With Antifibrinolytic (Epsilon Aminocaproic Acid)

    NCT02074436 · start 2014-05-23

    Registered record
    Registry ID
    NCT02074436
    Conditions
    Hematological Malignancies; Thrombocytopenia
    Interventions
    EACA; Platelet transfusion
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2014-05-23
    Completion
    2021-05-14
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHematological Malignancies; Thrombocytopenia
    InterventionEACA; Platelet transfusion
    PhasePhase 2
    Registry statusTerminated

  • Clinical Efficacy of Tranexamic Acid and ε-Aminocaproic Acid in Reducing Blood Loss Following Total Knee Replacement

    NCT01873768 · start 2014-01

    Registered record
    Registry ID
    NCT01873768
    Conditions
    Osteoarthritis
    Interventions
    Tranexamic Acid (TXA); ε-Aminocaproic Acid (EACA)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-01
    Completion
    2015-12
    Enrolment
    194

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    InterventionTranexamic Acid (TXA); ε-Aminocaproic Acid (EACA)
    PhasePhase 4
    Registry statusCompleted

  • Randomized Clinical Trial With Aminocaproic Acid in the Prevention of Exodontic Bleeding in Anticoagulants Patients

    NCT02238288 · start 2013-12

    Registered record
    Registry ID
    NCT02238288
    Conditions
    Oral Hemorrhage
    Interventions
    Aminocaproic acid; Routine dental care; lidocaine and epinephrine; Paracetamol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-12
    Completion
    2015-07
    Enrolment
    154

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Hemorrhage
    InterventionAminocaproic acid; Routine dental care; lidocaine and epinephrine; Paracetamol
    PhasePhase 4
    Registry statusUnknown

  • ICON1: Treatment Decisions and Outcomes in Pediatric Refractory ITP

    NCT01971684 · start 2013-08

    Registered record
    Registry ID
    NCT01971684
    Conditions
    Immune Thrombocytopenia
    Interventions
    Second Line ITP agents
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-08
    Completion
    2017-04
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImmune Thrombocytopenia
    InterventionSecond Line ITP agents
    PhaseNot recorded
    Registry statusCompleted

  • Fibrinolysis Before Cardiopulmonary Bypass?

    NCT01981863 · start 2013-07

    Registered record
    Registry ID
    NCT01981863
    Conditions
    Pathologic Fibrinolysis
    Interventions
    Epsilonaminocaproic acid; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-07
    Completion
    2014-02
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPathologic Fibrinolysis
    InterventionEpsilonaminocaproic acid; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Dosing of Amicar and Measure of Fibrinolysis by TEG During Cardiac Surgery

    NCT01965730 · start 2013-01

    Registered record
    Registry ID
    NCT01965730
    Conditions
    Aortic Disease
    Interventions
    epsilon-aminocaproic acid (EACA)
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2013-01
    Completion
    2014-06
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAortic Disease
    Interventionepsilon-aminocaproic acid (EACA)
    PhaseEarly phase 1
    Registry statusTerminated

  • Epsilon Aminocaproic Acid Vs. Tranexamic Acid Vs. Placebo for Prevention of Blood Loss in Total Knee Arthroplasty

    NCT01527968 · start 2012-04

    Registered record
    Registry ID
    NCT01527968
    Conditions
    Osteoarthritis
    Interventions
    Tranexamic Acid; Epsilon Aminocaproic Acid; Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2012-04
    Completion
    2016-12
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    InterventionTranexamic Acid; Epsilon Aminocaproic Acid; Normal Saline
    PhaseNot applicable
    Registry statusUnknown

  • Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

    NCT01431326 · start 2011-11

    Registered record
    Registry ID
    NCT01431326
    Conditions
    Adenovirus; Anesthesia; Anxiety; Anxiolysis; Autism; Autistic Disorder; Bacterial Meningitis; Bacterial Septicemia; Benzodiazepine; Bipolar Disorder; Bone and Joint Infections; Central Nervous System Infections; Convulsions; Cytomegalovirus Retinitis; Early-onset Schizophrenia Spectrum Disorders; Epilepsy; General Anesthesia; Gynecologic Infections; Herpes Simplex Virus; Infantile Hemangioma; Infection; Inflammation; Inflammatory Conditions; Intra-abdominal Infections; Lower Respiratory Tract Infections; Migraines; Pain; Pneumonia; Schizophrenia; Sedation; Seizures; Skeletal Muscle Spasms; Skin and Skin-structure Infections; Treatment-resistant Schizophrenia; Urinary Tract Infections; Withdrawal; Sepsis; Gram-negative Infection; Bradycardia; Cardiac Arrest; Cardiac Arrhythmia; Staphylococcal Infections; Nosocomial Pneumonia; Neuromuscular Blockade; Methicillin Resistant Staphylococcus Aureus; Endocarditis; Neutropenia; Headache; Fibrinolytic Bleeding; Pulmonary Arterial Hypertension; C
    Interventions
    The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-11
    Completion
    2019-11
    Enrolment
    3,520

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenovirus; Anesthesia; Anxiety; Anxiolysis +47 more
    InterventionThe POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
    PhaseNot recorded
    Registry statusCompleted

  • Epsilon Aminocaproic Acid (EACA) for the Reduction of Blood Loss in Total Hip Arthroplasty (THA)

    NCT01391182 · start 2011-07

    Registered record
    Registry ID
    NCT01391182
    Conditions
    Degenerative Joint Disease; Osteoarthritis
    Interventions
    EACA; Placebo arm
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-07
    Completion
    2015-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDegenerative Joint Disease; Osteoarthritis
    InterventionEACA; Placebo arm
    PhaseNot applicable
    Registry statusCompleted

  • Effects of Aminocaproic Acid (ACA) on Rosacea-specific Inflammation

    NCT01398280 · start 2011-07

    Registered record
    Registry ID
    NCT01398280
    Conditions
    Rosacea
    Interventions
    Topical aminocaproic acid (ACA) mixed with Vanicream; Vehicle cream
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2011-07
    Completion
    2012-12
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRosacea
    InterventionTopical aminocaproic acid (ACA) mixed with Vanicream; Vehicle cream
    PhaseEarly phase 1
    Registry statusCompleted

  • Pharmacokinetics of Aminocaproic Acid in Scoliosis Surgery

    NCT01408823 · start 2011-07

    Registered record
    Registry ID
    NCT01408823
    Conditions
    Scoliosis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-07
    Completion
    2011-10
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScoliosis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery

    NCT01248104 · start 2010-03

    Registered record
    Registry ID
    NCT01248104
    Conditions
    Cardiopulmonary Bypass
    Interventions
    Tranexamic Acid; Aminocaproic Acid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-03
    Completion
    2015-02
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiopulmonary Bypass
    InterventionTranexamic Acid; Aminocaproic Acid
    PhaseNot applicable
    Registry statusCompleted

  • Amicar Pharmacokinetics of Children Having Craniofacial Surgery

    NCT00912119 · start 2009-05

    Registered record
    Registry ID
    NCT00912119
    Conditions
    Craniosynostosis
    Interventions
    Epsilon-Aminocaproic Acid; Epsilon-Aminocaproic Acid; Epsilon-Aminocaproic Acid; Epsilon-Aminocaproic Acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-05
    Completion
    2011-10
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCraniosynostosis
    InterventionEpsilon-Aminocaproic Acid; Epsilon-Aminocaproic Acid; Epsilon-Aminocaproic Acid; Epsilon-Aminocaproic Acid
    PhasePhase 1
    Registry statusCompleted

  • The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis

    NCT02616042 · start 2009-03

    Registered record
    Registry ID
    NCT02616042
    Conditions
    Labor Trial Refused
    Interventions
    Centella asiatica and bamboo salt; Centella asiatica
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-03
    Completion
    2009-12
    Enrolment
    33

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLabor Trial Refused
    InterventionCentella asiatica and bamboo salt; Centella asiatica
    PhasePhase 3
    Registry statusCompleted