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AMR Drug RepurposingSmart Screeningresearch prototype

Cefotetan Disodium

FDA-approved product (injectable, injection), marketed as Cefotan, Cefotan In Plastic Container, Cefotetan and 1 more.

Registered studies
7
Lab records
2
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Cefotetan Disodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Second-generation cephalosporins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DC05

Repurposing investigation

Cefotetan Disodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA57.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli85.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae93.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis57.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

7registered studies name this medicine, for any condition. See them below.

Experimental

  • E. coli: measured active in 1 of 1 lab record
  • K. pneumoniae: measured active in 1 of 1 lab record
Open Cefotetan Disodium in ChEMBL Registered studies below
Show the 2 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cefotetan Disodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Cefotetan Therapy for Escherichia Coli Infections

    NCT07318584 · start 2026-03

    Registered record
    Registry ID
    NCT07318584
    Conditions
    E Coli Infection; ESBL Producing E.Coli
    Interventions
    Cefotetan; Carbapenems; Beta Lactam Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-03
    Completion
    2028-08
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionE Coli Infection; ESBL Producing E.Coli
    InterventionCefotetan; Carbapenems; Beta Lactam Antibiotics
    PhasePhase 2
    Registry statusNot yet recruiting

  • Effectiveness of Prophylactic Antibiotics Therapy in Laparoscopic Cholecystectomy on Infection Rate

    NCT04726046 · start 2014-04-01

    Registered record
    Registry ID
    NCT04726046
    Conditions
    Cholecystitis
    Interventions
    Cefotetan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-04-01
    Completion
    2017-09-25
    Enrolment
    529

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCholecystitis
    InterventionCefotetan
    PhasePhase 1
    Registry statusCompleted

  • Patients Response to Early Switch To Oral:Osteomyelitis Study

    NCT02099240 · start 2014-03-06

    Registered record
    Registry ID
    NCT02099240
    Conditions
    Osteomyelitis
    Interventions
    oral antibiotics; intravenous antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2014-03-06
    Completion
    2018-11-07
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventionoral antibiotics; intravenous antibiotics
    PhaseEarly phase 1
    Registry statusTerminated

  • Safety and Efficacy of One Dose Prophylactic Antibiotic in Laparoscopic Colorectal Surgery

    NCT01220661 · start 2010-10

    Registered record
    Registry ID
    NCT01220661
    Conditions
    Colorectal Surgery
    Interventions
    Cefotetan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-10
    Completion
    2011-12
    Enrolment
    312

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Surgery
    InterventionCefotetan
    PhasePhase 2
    Registry statusCompleted

  • Arthroscopic Rotator Cuff Repair With Multimodal Analgesia(MMA)

    NCT01204606 · start 2010-09

    Registered record
    Registry ID
    NCT01204606
    Conditions
    Rotator Cuff Tear
    Interventions
    Arthroscopic rotator cuff repair with intraoperative periarticular injection; Arthroscopic rotator cuff repair with non-injection of MMA drugs
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-09
    Completion
    Not recorded
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Tear
    InterventionArthroscopic rotator cuff repair with intraoperative periarticular injection; Arthroscopic rotator cuff repair with non-injection of MMA drugs
    PhaseNot applicable
    Registry statusCompleted

  • Antibiotics for Postpartum Third and Fourth Degree Perineal Tear Repairs

    NCT00186082 · start 2003-09

    Registered record
    Registry ID
    NCT00186082
    Conditions
    Pregnancy Complications, Infectious
    Interventions
    Cefotetan or Cefoxitin vs placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-09
    Completion
    2008-06
    Enrolment
    147

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy Complications, Infectious
    InterventionCefotetan or Cefoxitin vs placebo
    PhaseNot applicable
    Registry statusCompleted

  • A Single Dose of a Marketed Drug Being Studied for a New Indication to Treat Surgical Site Infection Following Colorectal Surgery as Compared to a Marketed Drug Approved for This Indication (0826-039)

    NCT00090272 · start 2002-04

    Registered record
    Registry ID
    NCT00090272
    Conditions
    Colorectal Surgery
    Interventions
    MK0826, ertapenem sodium; Comparator: cefotetan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-04
    Completion
    2005-03
    Enrolment
    952

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Surgery
    InterventionMK0826, ertapenem sodium; Comparator: cefotetan
    PhasePhase 3
    Registry statusCompleted