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AMR Drug RepurposingSmart Screeningresearch prototype

Pravastatin Sodium

FDA-approved product (tablet, oral), marketed as Pravachol, Pravastatin Sodium.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Pravastatin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Atherosclerosis
  • Cardiovascular disease
  • Coronary artery disease
  • Coronary atherosclerosis
  • Familial hypercholesterolemia
  • Hypercholesterolemia
  • Myocardial infarction

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Hmg coa reductase inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli34.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae28.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis47.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Pravastatin Sodium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Pravastatin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Quality of Life in Patients With Statin-Associated Myopathy

    NCT00850460 · start 2009-02

    Registered record
    Registry ID
    NCT00850460
    Conditions
    Statin Adverse Reaction
    Interventions
    Statins; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2009-02
    Completion
    2013-02
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStatin Adverse Reaction
    InterventionStatins; Placebo
    PhasePhase 4
    Registry statusTerminated

  • Efficacy and Safety of Prescription Omega-3 Fatty Acid Added to Stable Statin Therapy in Patients With Type 2 Diabetes and Hypertriglyceridemia

    NCT02305355 · start 2009-02

    Registered record
    Registry ID
    NCT02305355
    Conditions
    Diabetes Mellitus, Type 2; Hypertriglycemia
    Interventions
    Omega-3-acids ethylesters 90 4g; Pravastatin, Simvastatin, Atorvastatin, Rosuvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-02
    Completion
    2011-02
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus, Type 2; Hypertriglycemia
    InterventionOmega-3-acids ethylesters 90 4g; Pravastatin, Simvastatin, Atorvastatin, Rosuvastatin
    PhasePhase 4
    Registry statusCompleted

  • South Korean Pitavastatin Heart Failure Study

    NCT00701285 · start 2008-07

    Registered record
    Registry ID
    NCT00701285
    Conditions
    Chronic Heart Failure
    Interventions
    pitavastatin; pravastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-07
    Completion
    2014-05
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Heart Failure
    Interventionpitavastatin; pravastatin
    PhasePhase 4
    Registry statusCompleted

  • Genetic Predictors of Variability in the Drug-drug Interaction Between Darunavir/Ritonavir and Pravastatin

    NCT00630734 · start 2008-02

    Registered record
    Registry ID
    NCT00630734
    Conditions
    HIV Infections; Hyperlipidemia
    Interventions
    Pravastatin; Darunavir; Ritonavir; Pravastatin; Washout
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-02
    Completion
    2010-09
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Hyperlipidemia
    InterventionPravastatin; Darunavir; Ritonavir; Pravastatin +1 more
    PhasePhase 4
    Registry statusCompleted

  • Observational Study of Approaches to Lipid-Lowering Therapy in Russian Patients With Coronary Heart Disease <<Treat to Goal>> (Study P05464)

    NCT00730132 · start 2008-01

    Registered record
    Registry ID
    NCT00730132
    Conditions
    Coronary Heart Disease; Hypercholesterolemia
    Interventions
    Ezetimibe; Statin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-01
    Completion
    2009-08
    Enrolment
    712

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Heart Disease; Hypercholesterolemia
    InterventionEzetimibe; Statin
    PhaseNot recorded
    Registry statusCompleted

  • A Study to Evaluate Daily Pravastatin, Fenofibrate or Pravafen in the Treatment of Combined Hyperlipidemia

    NCT00459745 · start 2007-04

    Registered record
    Registry ID
    NCT00459745
    Conditions
    Combined Hyperlipidemia
    Interventions
    Pravafen; Pravastatin; Fenofibrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-04
    Completion
    2009-07
    Enrolment
    481

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCombined Hyperlipidemia
    InterventionPravafen; Pravastatin; Fenofibrate
    PhasePhase 3
    Registry statusCompleted

  • Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome

    NCT00467831 · start 2007-04

    Registered record
    Registry ID
    NCT00467831
    Conditions
    Hermansky-Pudlak Syndrome (HPS); Pulmonary Fibrosis; Oculocutaneous Albinism; Platelet Storage Pool Deficiency; Metabolic Disease
    Interventions
    Losartan; Zileuton; N-Acetylcysteine; Pravastatin; Erythromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2007-04
    Completion
    2012-11
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHermansky-Pudlak Syndrome (HPS); Pulmonary Fibrosis; Oculocutaneous Albinism; Platelet Storage Pool Deficiency +1 more
    InterventionLosartan; Zileuton; N-Acetylcysteine; Pravastatin +1 more
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • Etoposide and Cisplatin or Carboplatin as First-Line Chemotherapy With or Without Pravastatin in Treating Patients With Small Cell Lung Cancer

    NCT00433498 · start 2007-01

    Registered record
    Registry ID
    NCT00433498
    Conditions
    Lung Cancer
    Interventions
    carboplatin; cisplatin; etoposide phosphate; pravastatin sodium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-01
    Completion
    2013-11
    Enrolment
    846

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLung Cancer
    Interventioncarboplatin; cisplatin; etoposide phosphate; pravastatin sodium
    PhasePhase 3
    Registry statusCompleted

  • Pravastatin 80 mg Tablets Dosed in Healthy Subjects Under Non-Fasting Conditions

    NCT00829309 · start 2005-03

    Registered record
    Registry ID
    NCT00829309
    Conditions
    Healthy
    Interventions
    Pravastatin; Pravastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2005-03
    Completion
    2005-03
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionPravastatin; Pravastatin
    PhasePhase 1
    Registry statusCompleted

  • Japan Statin Treatment Against Recurrent Stroke (J-STARS)

    NCT00221104 · start 2004-03-01

    Registered record
    Registry ID
    NCT00221104
    Conditions
    Ischemic Stroke
    Interventions
    Pravastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-03-01
    Completion
    Not recorded
    Enrolment
    1,578

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIschemic Stroke
    InterventionPravastatin
    PhasePhase 3
    Registry statusCompleted

  • Improving Symptoms of Schizophrenia and Schizoaffective Disorder by Supplementing Medications With Pravastatin

    NCT00177580 · start 2003-07

    Registered record
    Registry ID
    NCT00177580
    Conditions
    Schizophrenia; Schizoaffective Disorder
    Interventions
    Pravastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-07
    Completion
    2007-07
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder
    InterventionPravastatin
    PhasePhase 4
    Registry statusCompleted

  • Fasting Bioequivalence Study of Pravastatin Sodium 80 mg Tablets Versus Pravachol® 80 mg Tablets In Normal Healthy Subjects

    NCT00650221 · start 2003-06

    Registered record
    Registry ID
    NCT00650221
    Conditions
    Therapeutic Equivalency
    Interventions
    Pravastatin; Pravastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2003-06
    Completion
    2003-07
    Enrolment
    43

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTherapeutic Equivalency
    InterventionPravastatin; Pravastatin
    PhasePhase 1
    Registry statusCompleted

  • Prevention of Atherosclerosis and Heart Disease in Patients With Systemic Lupus Erythematosis (SLE)

    NCT00054938 · start 2003-03

    Registered record
    Registry ID
    NCT00054938
    Conditions
    Systemic Lupus Erythematosus; Lupus
    Interventions
    pravastatin; aspirin; ramipril; Vitamins: B6, B12, and folate; heart health educational program
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-03
    Completion
    2005-12
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSystemic Lupus Erythematosus; Lupus
    Interventionpravastatin; aspirin; ramipril; Vitamins: B6, B12, and folate +1 more
    PhasePhase 2
    Registry statusCompleted

  • Pravastatin for Hyperlipidaemia in HIV.

    NCT00227500 · start 2001-07

    Registered record
    Registry ID
    NCT00227500
    Conditions
    HIV Infections; Lipid Metabolism; Glucose Metabolism; Metabolic Abnormality; Lipodystrophy; Cardiovascular Disease
    Interventions
    Pravastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2001-07
    Completion
    2004-10
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Lipid Metabolism; Glucose Metabolism; Metabolic Abnormality +2 more
    InterventionPravastatin
    PhasePhase 4
    Registry statusCompleted

  • Bioavailability Study of Pravastatin Sodium 40 mg Tablets Under Fasting Conditions

    NCT00834379 · start 2000-09

    Registered record
    Registry ID
    NCT00834379
    Conditions
    Healthy
    Interventions
    pravastatin sodium; Pravachol®
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2000-09
    Completion
    2000-09
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionpravastatin sodium; Pravachol®
    PhasePhase 1
    Registry statusCompleted