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AMR Drug RepurposingSmart Screeningresearch prototype

Pravastatin Sodium

FDA-approved product (tablet, oral), marketed as Pravachol, Pravastatin Sodium.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Pravastatin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Atherosclerosis
  • Cardiovascular disease
  • Coronary artery disease
  • Coronary atherosclerosis
  • Familial hypercholesterolemia
  • Hypercholesterolemia
  • Myocardial infarction

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Hmg coa reductase inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli34.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae28.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis47.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Pravastatin Sodium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Pravastatin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes

    NCT02754739 · start 2014-04-15

    Registered record
    Registry ID
    NCT02754739
    Conditions
    Diabetes Mellitus; Prediabetic State
    Interventions
    Pravastatin; Placebo (for Pravastatin); Nutritional education only
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-04-15
    Completion
    2017-08-31
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus; Prediabetic State
    InterventionPravastatin; Placebo (for Pravastatin); Nutritional education only
    PhasePhase 4
    Registry statusCompleted

  • A Trial Comparing the Effect of Pravastatin and Rosuvastatin on Atherosclerosis Progression Measured by Carotid Intima Media Thickness in Patients With Coronary Artery Disease After Biolimus Eluting Stent (Nobori®) Implantation: CPR IMT

    NCT01872845 · start 2013-06-12

    Registered record
    Registry ID
    NCT01872845
    Conditions
    Coronary Artery Occlusive Disease
    Interventions
    Pravastatin 40mg; Rosuvastatin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-06-12
    Completion
    2017-05-25
    Enrolment
    671

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Occlusive Disease
    InterventionPravastatin 40mg; Rosuvastatin
    PhaseNot applicable
    Registry statusCompleted

  • Statin Recapture Therapy Before Coronary Artery Bypass Grafting

    NCT01715714 · start 2012-11-07

    Registered record
    Registry ID
    NCT01715714
    Conditions
    Coronary Artery Disease
    Interventions
    Statin Recapture Therapy; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-11-07
    Completion
    2020-09-27
    Enrolment
    2,630

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease
    InterventionStatin Recapture Therapy; Placebo
    PhasePhase 4
    Registry statusCompleted

  • The Statins on Glucose Homeostasis in Subjects With Impaired Fasting Glucose

    NCT01816997 · start 2012-01

    Registered record
    Registry ID
    NCT01816997
    Conditions
    Diabetes
    Interventions
    Pravastatin; Rosuvastatin; Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-01
    Completion
    2022-12
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes
    InterventionPravastatin; Rosuvastatin; Control
    PhasePhase 4
    Registry statusUnknown

  • A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin

    NCT01492361 · start 2011-11

    Registered record
    Registry ID
    NCT01492361
    Conditions
    Cardiovascular Diseases
    Interventions
    AMR101; Placebo; Statin therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-11
    Completion
    2018-05
    Enrolment
    8,179

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Diseases
    InterventionAMR101; Placebo; Statin therapy
    PhasePhase 3
    Registry statusCompleted

  • Cyclosporine, Pravastatin Sodium, Etoposide, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

    NCT01342887 · start 2011-04

    Registered record
    Registry ID
    NCT01342887
    Conditions
    Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13; q22); Adult Acute Myeloid Leukemia With t(16; 16)(p13; q22); Adult Acute Myeloid Leukemia With t(8; 21)(q22; q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia
    Interventions
    cyclosporine; pravastatin sodium; mitoxantrone hydrochloride; etoposide; bone marrow aspiration
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2011-04
    Completion
    2012-03
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b) +16 more
    Interventioncyclosporine; pravastatin sodium; mitoxantrone hydrochloride; etoposide +1 more
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • A Drug-Drug Interaction Study Between AZD1981 and Pravastatin to Study the Effect of AZD1981 on the Kinetics of Pravastatin

    NCT01254461 · start 2011-02

    Registered record
    Registry ID
    NCT01254461
    Conditions
    Drug Interaction
    Interventions
    AZD1981; AZD1981; pravastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-02
    Completion
    2011-04
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Interaction
    InterventionAZD1981; AZD1981; pravastatin
    PhasePhase 1
    Registry statusCompleted

  • High Potency Statins and Acute Kidney Injury

    NCT02518516 · start 2011-01

    Registered record
    Registry ID
    NCT02518516
    Conditions
    Hypercholesterolemia
    Interventions
    Rosuvastatin (≥10 mg); Atorvastatin (≥20 mg); Simvastatin (≥40 mg); Fluvastatin; Pravastatin; Lovastatin; Atorvastatin (<20mg); Simvastatin (<40 mg)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-01
    Completion
    2013-01
    Enrolment
    2,067,639

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    InterventionRosuvastatin (≥10 mg); Atorvastatin (≥20 mg); Simvastatin (≥40 mg); Fluvastatin +4 more
    PhaseNot recorded
    Registry statusCompleted

  • Curative Efficacy of Pravastatine in Patients Presented Delayed Cutaneous and Subcutaneous Radio-induced Fibrosis

    NCT01268202 · start 2010-12-17

    Registered record
    Registry ID
    NCT01268202
    Conditions
    Fibrosis
    Interventions
    Pravastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-12-17
    Completion
    2019-04-18
    Enrolment
    61

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFibrosis
    InterventionPravastatin
    PhasePhase 2
    Registry statusCompleted

  • Evaluation of Patients With Statin Myopathy Using an N of 1 Trial Design

    NCT01259791 · start 2010-09

    Registered record
    Registry ID
    NCT01259791
    Conditions
    Statin Myopathy
    Interventions
    Individual-specific statin causing myopathy; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-09
    Completion
    2013-08
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStatin Myopathy
    InterventionIndividual-specific statin causing myopathy; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Intensive Statin Treatment in Chinese Coronary Artery Disease Patients Undergoing PCI

    NCT01293097 · start 2010-06

    Registered record
    Registry ID
    NCT01293097
    Conditions
    Non-ST Segment Elevation Myocardial Infarction; Unstable Angina Pectoris; Stable Angina Pectoris
    Interventions
    Atorvastatin; Statin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-06
    Completion
    2011-10
    Enrolment
    2,884

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-ST Segment Elevation Myocardial Infarction; Unstable Angina Pectoris; Stable Angina Pectoris
    InterventionAtorvastatin; Statin
    PhasePhase 4
    Registry statusCompleted

  • Effect of AMR101 (Ethyl Icosapentate) on Triglyceride (Tg) Levels in Patients on Statins With High Tg Levels (≥ 200 and < 500 mg/dL)

    NCT01047501 · start 2009-12

    Registered record
    Registry ID
    NCT01047501
    Conditions
    Hypertriglyceridemia
    Interventions
    AMR101 (ethyl icosapentate) - 4 g/day; AMR101 (ethyl icosapentate) - 2 g/day; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-12
    Completion
    2011-02
    Enrolment
    702

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertriglyceridemia
    InterventionAMR101 (ethyl icosapentate) - 4 g/day; AMR101 (ethyl icosapentate) - 2 g/day; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Efficacy and Safety of AMR101 (Ethyl Icosapentate) in Patients With Fasting Triglyceride (Tg) Levels ≥ 500 and ≤ 2000 mg/dL

    NCT01047683 · start 2009-12

    Registered record
    Registry ID
    NCT01047683
    Conditions
    Hypertriglyceridemia
    Interventions
    AMR101 (ethyl icosapentate) - 4 g/day; AMR101 (ethyl icosapentate) - 2 g/day; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-12
    Completion
    2011-07
    Enrolment
    229

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertriglyceridemia
    InterventionAMR101 (ethyl icosapentate) - 4 g/day; AMR101 (ethyl icosapentate) - 2 g/day; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Effect of Succinylcholine on Patients Using Statins

    NCT00986583 · start 2009-09

    Registered record
    Registry ID
    NCT00986583
    Conditions
    Pain
    Interventions
    Succinylcholine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2010-07
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionSuccinylcholine
    PhaseNot applicable
    Registry statusCompleted

  • Statin Interchange by Pharmacist Collaborative Practice Agreement (CPA)

    NCT01222182 · start 2009-09

    Registered record
    Registry ID
    NCT01222182
    Conditions
    Hypercholesterolemia
    Interventions
    atorvastatin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-09
    Completion
    2011-06
    Enrolment
    260

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    Interventionatorvastatin
    PhaseNot recorded
    Registry statusCompleted