Pravastatin Sodium
FDA-approved product (tablet, oral), marketed as Pravachol, Pravastatin Sodium.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 2 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Atherosclerosis
- Cardiovascular disease
- Coronary artery disease
- Coronary atherosclerosis
- Familial hypercholesterolemia
- Hypercholesterolemia
- Myocardial infarction
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Hmg coa reductase inhibitors
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA46.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli34.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae28.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis47.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Pravastatin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Enalapril MaleateExisting use: Cardiovascular disease, Congestive heart failure, Heart failure and 2 more69.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
- ElbasvirExisting use: Chronic hepatitis C virus infection, Viral disease69.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
- BendroflumethiazideExisting use: Cardiovascular disease, Hypertension68.8% AI-predicted activityagainst M. tuberculosis9 registered studies
- ChlorthalidoneExisting use: Angina pectoris, Cardiovascular disease, Chronic kidney disease and 6 more68.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- ChlorothiazideExisting use: Cardiovascular disease, Chronic kidney disease, Congestive heart failure and 6 more68.7% AI-predicted activityagainst M. tuberculosis50+ registered studies
- HaloperidolExisting use: Conduct disorder, Mental or behavioural disorder, Psychosis and 4 more68.4% AI-predicted activityagainst M. tuberculosis50+ registered studies
- MethotrexateExisting use: Acute lymphoblastic leukemia, Adenoma, Arthritis and 21 more68.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
- RiociguatExisting use: Hypertension, Idiopathic and/or familial pulmonary arterial hypertension, Pulmonary arterial hypertension and 1 more68.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- TrichlormethiazideExisting use: Cardiovascular disease67.9% AI-predicted activityagainst M. tuberculosis1 registered study
- Promazine HydrochlorideExisting use: Psychosis67.8% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- VandetanibExisting use: Cancer, Medullary thyroid gland carcinoma, Neoplasm and 4 more67.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- HydroflumethiazideExisting use: Cardiovascular disease67.7% AI-predicted activityagainst M. tuberculosis1 registered study
Registered studies
A registration describes a study; it does not establish a positive result.
A Study Comparing the Mechanisms of Action of Lifibrol and Pravastatin
NCT01057654 · start 1996-01
Registered record
- Registry ID
- NCT01057654
- Conditions
- Hypercholesterolemia; Hyperlipoproteinemia
- Interventions
- Pravastatin; Lifibrol
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 1996-01
- Completion
- 1998-06
- Enrolment
- 18
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHypercholesterolemia; HyperlipoproteinemiaInterventionPravastatin; LifibrolPhasePhase 3Registry statusCompletedManagement of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA Study)
NCT00211705 · start 1994-02
Registered record
- Registry ID
- NCT00211705
- Conditions
- Hyperlipidemia
- Interventions
- Diet; Diet+pravastatin
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 1994-02
- Completion
- 2004-03
- Enrolment
- 8,000
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHyperlipidemiaInterventionDiet; Diet+pravastatinPhasePhase 4Registry statusCompletedA Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood
NCT00000941
Registered record
- Registry ID
- NCT00000941
- Conditions
- HIV Infections
- Interventions
- Pravastatin sodium; Simvastatin; Atorvastatin calcium; Ritonavir; Nelfinavir mesylate; Saquinavir
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2002-03
- Enrolment
- 56
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV InfectionsInterventionPravastatin sodium; Simvastatin; Atorvastatin calcium; Ritonavir +2 morePhasePhase 1Registry statusCompletedPrevention of Kidney Transplant Rejection
NCT00005010
Registered record
- Registry ID
- NCT00005010
- Conditions
- End-Stage Renal Disease; Chronic Allograft Nephropathy
- Interventions
- Irbesartan; Pravastatin
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2004-03
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionEnd-Stage Renal Disease; Chronic Allograft NephropathyInterventionIrbesartan; PravastatinPhasePhase 3Registry statusCompletedSafety and Effectiveness of Fenofibrate and Pravastatin in HIV-Positive Patients With Abnormal Blood Lipids
NCT00006412
Registered record
- Registry ID
- NCT00006412
- Conditions
- HIV Infections; Lipodystrophy
- Interventions
- Pravastatin sodium; Fenofibrate
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2003-05
- Enrolment
- 630
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV Infections; LipodystrophyInterventionPravastatin sodium; FenofibratePhasePhase 3Registry statusCompleted