Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Triamcinolone Hexacetonide

FDA-approved product (injectable, injection), marketed as Aristospan.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Triamcinolone Hexacetonide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion
  • Osteoarthritis
  • Skin disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids for local oral treatment; Corticosteroids; Corticosteroids, moderately potent (group ii); Corticosteroids, moderately potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA53.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli36.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae28.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Triamcinolone Hexacetonide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.7 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triamcinolone Hexacetonide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Mixed Gel of Hydrocortisone and Aluminium Phosphate Preventing Endoscopic Submucosal Dissection Postoperative Stenosis for Patients With Large Esophageal Carcinoma

    NCT03165344 · start 2017-02-10

    Registered record
    Registry ID
    NCT03165344
    Conditions
    Esophageal Stenosis Acquired
    Interventions
    Hydrocortisone sodium succinate mixed with Aluminium Phosphate gel (route of administration); Triamcinolone Acetonide (route of administration); Prednisone (route of administration)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-02-10
    Completion
    2019-12-31
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEsophageal Stenosis Acquired
    InterventionHydrocortisone sodium succinate mixed with Aluminium Phosphate gel (route of administration); Triamcinolone Acetonide (route of administration); Prednisone (route of administration)
    PhaseNot applicable
    Registry statusCompleted

  • Topical Steroid Formulation and Wet Wraps

    NCT02680301 · start 2016-03

    Registered record
    Registry ID
    NCT02680301
    Conditions
    Dermatitis, Atopic
    Interventions
    0.1% triamcinolone CREAM; 0.1% triamcinolone OINTMENT
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-03
    Completion
    2018-06-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis, Atopic
    Intervention0.1% triamcinolone CREAM; 0.1% triamcinolone OINTMENT
    PhasePhase 4
    Registry statusCompleted

  • Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris

    NCT02828163 · start 2016-01

    Registered record
    Registry ID
    NCT02828163
    Conditions
    Oral Pemphigus Vulgaris
    Interventions
    Autologous Platelet rich plasma; Triamcinolone Acetonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-01
    Completion
    2016-10
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Pemphigus Vulgaris
    InterventionAutologous Platelet rich plasma; Triamcinolone Acetonide
    PhasePhase 3
    Registry statusCompleted

  • A Comparison of Dexamethasone and Triamcinolone for Ultrasound-guided Occipital C2 Nerve Blocks

    NCT02655523 · start 2015-12

    Registered record
    Registry ID
    NCT02655523
    Conditions
    Headache
    Interventions
    Triamcinolone; Dexamethasone; Normal Saline; Bupivacaine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2015-12
    Completion
    2022-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeadache
    InterventionTriamcinolone; Dexamethasone; Normal Saline; Bupivacaine
    PhasePhase 4
    Registry statusWithdrawn

  • Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee

    NCT02637323 · start 2015-11

    Registered record
    Registry ID
    NCT02637323
    Conditions
    Osteoarthritis of the Knee
    Interventions
    FX006 32 mg; TCA IR 40
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-11
    Completion
    2016-09
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis of the Knee
    InterventionFX006 32 mg; TCA IR 40
    PhasePhase 2
    Registry statusCompleted

  • Assessing the Efficacy of Needling With or Without Corticosteroids in the Repigmentation of Vitiligo

    NCT02191748 · start 2014-09

    Registered record
    Registry ID
    NCT02191748
    Conditions
    Vitiligo
    Interventions
    Needling; Triamcinolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2014-09
    Completion
    2018-01
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitiligo
    InterventionNeedling; Triamcinolone
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • Triamcinolone for Ahmed Glaucoma Valve

    NCT02653963 · start 2014-09

    Registered record
    Registry ID
    NCT02653963
    Conditions
    Glaucoma
    Interventions
    Adjunctival Triamcinolone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-09
    Completion
    2016-12
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma
    InterventionAdjunctival Triamcinolone
    PhaseNot applicable
    Registry statusCompleted

  • Canakinumab in the Treatment of Gouty Arthritis Flare(s) and Prevention of New Flares in Patients With Chronic Kidney Disease

    NCT01593527 · start 2012-09

    Registered record
    Registry ID
    NCT01593527
    Conditions
    Acute Gouty Arthritis
    Interventions
    ACZ885; Triamcinelone acetonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2012-09
    Completion
    2012-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Gouty Arthritis
    InterventionACZ885; Triamcinelone acetonide
    PhasePhase 3
    Registry statusWithdrawn

  • Postoperative Systemic Corticosteroids When Utilizing a Steroid-Eluting Spacer Following Endoscopic Sinus Surgery

    NCT01564355 · start 2012-04

    Registered record
    Registry ID
    NCT01564355
    Conditions
    Chronic Sinusitis; Endoscopic Sinus Surgery; Post-operative Care; Steroids; Drug-eluting Spacer
    Interventions
    Steroid-eluting middle meatal spacer (Nasopore (TM) spacer impregnated with 1 cc of 40mg/mL triamcinolone liquid); Post-op Oral Steroids
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-04
    Completion
    2013-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Sinusitis; Endoscopic Sinus Surgery; Post-operative Care; Steroids +1 more
    InterventionSteroid-eluting middle meatal spacer (Nasopore (TM) spacer impregnated with 1 cc of 40mg/mL triamcinolone liquid); Post-op Oral Steroids
    PhaseNot applicable
    Registry statusCompleted

  • A Clinical Comparison in Cervical Epidural Pressure Changes Between Midline and Paramedian Approaches

    NCT01360138 · start 2011-05

    Registered record
    Registry ID
    NCT01360138
    Conditions
    Herniated Nucleus Pulposus; Whiplash Injury
    Interventions
    Cervical epidural steroid injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2011-05
    Completion
    2011-08
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHerniated Nucleus Pulposus; Whiplash Injury
    InterventionCervical epidural steroid injection
    PhaseNot applicable
    Registry statusUnknown

  • Low-dose Combination of Mycophenolate Mofetil (MMF) and Tacrolimus (Tac) for Refractory Lupus Nephritis

    NCT01203709 · start 2010-08

    Registered record
    Registry ID
    NCT01203709
    Conditions
    Lupus Nephritis
    Interventions
    low dose combination of MMF and Tac
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-08
    Completion
    2013-02
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLupus Nephritis
    Interventionlow dose combination of MMF and Tac
    PhasePhase 4
    Registry statusCompleted

  • Use of Intravitreal Triamcinolone and Retrobulbar Chlorpromazine as Alternatives to the Management of Painful Blind Eye

    NCT01404364 · start 2010-01

    Registered record
    Registry ID
    NCT01404364
    Conditions
    Blind Painful Eye; Refractory Glaucoma; Control of Pain Through Drug Injection
    Interventions
    Triamcinolone; Chlorpromazine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-01
    Completion
    2010-12
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlind Painful Eye; Refractory Glaucoma; Control of Pain Through Drug Injection
    InterventionTriamcinolone; Chlorpromazine
    PhaseNot applicable
    Registry statusCompleted

  • Treatment of Lateral Epicondylitis: Platelet Rich Plasma Versus Steroid Versus Saline Solution

    NCT01109446 · start 2009-01

    Registered record
    Registry ID
    NCT01109446
    Conditions
    Lateral Epicondylitis
    Interventions
    Platelet Rich Plasma; Isotonic Saline Solutions; Triamcinolonacetonid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-01
    Completion
    2011-10
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLateral Epicondylitis
    InterventionPlatelet Rich Plasma; Isotonic Saline Solutions; Triamcinolonacetonid
    PhaseNot applicable
    Registry statusCompleted

  • Treatment of Subacromial Shoulder Pain by Individual or Group Physiotherapy Following Corticosteroid Injection

    NCT04058522 · start 2008-09-19

    Registered record
    Registry ID
    NCT04058522
    Conditions
    Shoulder Pain; Rotator Cuff Impingement
    Interventions
    Rotator cuff rehabilitation classes; Individual Physiotherapy; Triamcinolone Injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-09-19
    Completion
    2013-02-10
    Enrolment
    136

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShoulder Pain; Rotator Cuff Impingement
    InterventionRotator cuff rehabilitation classes; Individual Physiotherapy; Triamcinolone Injection
    PhaseNot applicable
    Registry statusCompleted

  • Short-term Effects of Intravitreal Bevacizumab and Triamcinolone in Patients With Diabetic Macular Edema

    NCT00563940 · start 2007-03

    Registered record
    Registry ID
    NCT00563940
    Conditions
    Diabetic Macular Edema
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-03
    Completion
    2010-02
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Macular Edema
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted