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AMR Drug RepurposingSmart Screeningresearch prototype

Triamcinolone Hexacetonide

FDA-approved product (injectable, injection), marketed as Aristospan.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Triamcinolone Hexacetonide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion
  • Osteoarthritis
  • Skin disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids for local oral treatment; Corticosteroids; Corticosteroids, moderately potent (group ii); Corticosteroids, moderately potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA53.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli36.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae28.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Triamcinolone Hexacetonide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.7 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triamcinolone Hexacetonide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Dexmedetomidine Versus Triamcinolone Treatment of Carpal Tunnel Syndrome

    NCT04961281 · start 2021-07-22

    Registered record
    Registry ID
    NCT04961281
    Conditions
    Chronic Pain; Carpal Tunnel Syndrome
    Interventions
    Dexmedetomidine; Triamcinolone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-07-22
    Completion
    2022-08-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Pain; Carpal Tunnel Syndrome
    InterventionDexmedetomidine; Triamcinolone
    PhaseNot applicable
    Registry statusCompleted

  • Cell Therapy With Cellistem-OA for Symptomatic Knee Osteoarthritis

    NCT04863183 · start 2021-06-01

    Registered record
    Registry ID
    NCT04863183
    Conditions
    Mesenchymal Stem Cells; Knee Osteoarthritis; Cell Therapy
    Interventions
    CELLISTEM-OA; Triamcinolone acetonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2021-06-01
    Completion
    2022-06-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMesenchymal Stem Cells; Knee Osteoarthritis; Cell Therapy
    InterventionCELLISTEM-OA; Triamcinolone acetonide
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • Effect of Zilretta Injection

    NCT04261049 · start 2020-08-01

    Registered record
    Registry ID
    NCT04261049
    Conditions
    Osteoarthritis, Knee
    Interventions
    Triamcinolone Acetonide Extended-Release Injectable Suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2020-08-01
    Completion
    2022-01-10
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Knee
    InterventionTriamcinolone Acetonide Extended-Release Injectable Suspension
    PhasePhase 1
    Registry statusCompleted

  • Fractional Microneedling RF vs Intralesional Steroid With & Without Microneedling in Hypertrophic Scars

    NCT04389619 · start 2020-05-10

    Registered record
    Registry ID
    NCT04389619
    Conditions
    Hypertrophic Scars
    Interventions
    Fractional Microneedling Radiofrequency; Intralesional Steroid Injection with and without Microneedling
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-05-10
    Completion
    2020-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertrophic Scars
    InterventionFractional Microneedling Radiofrequency; Intralesional Steroid Injection with and without Microneedling
    PhaseNot applicable
    Registry statusUnknown

  • Suprachoroidal Triamcinolone Versus Posterior Subtenon Triamcinolone Alone or Formulated in the Management of Diabetic Macular Edema.

    NCT05464953 · start 2020-01-20

    Registered record
    Registry ID
    NCT05464953
    Conditions
    Diabetic Macular Edema of Left Eye
    Interventions
    Triamcinolone Acetonide; Formulated Triamcinolone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-01-20
    Completion
    2022-04-30
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Macular Edema of Left Eye
    InterventionTriamcinolone Acetonide; Formulated Triamcinolone
    PhaseNot applicable
    Registry statusCompleted

  • Increased Blood Glucose Levels After Steroid Injection

    NCT06228911 · start 2020-01-15

    Registered record
    Registry ID
    NCT06228911
    Conditions
    Osteoarthritis, Knee; Diabete Type 2
    Interventions
    steroid (triamcinolone)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-01-15
    Completion
    2023-09-15
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Knee; Diabete Type 2
    Interventionsteroid (triamcinolone)
    PhaseNot applicable
    Registry statusCompleted

  • Steroid-reducing Effects of Crisaborole

    NCT03832010 · start 2019-12-17

    Registered record
    Registry ID
    NCT03832010
    Conditions
    Atopic Dermatitis; Eczema
    Interventions
    Crisaborole; Hydrocortisone Ointment; Triamcinolone ointment; Aquaphor
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-12-17
    Completion
    2024-02-16
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtopic Dermatitis; Eczema
    InterventionCrisaborole; Hydrocortisone Ointment; Triamcinolone ointment; Aquaphor
    PhasePhase 4
    Registry statusCompleted

  • The Efficacy of Topical Sesame Oil Versus Topical Triamcinolone on Oral Lichen Planus and Salivary Level of Oxidative Stress Biomarker [MDA]

    NCT03738176 · start 2019-12-16

    Registered record
    Registry ID
    NCT03738176
    Conditions
    Oral Lichen Planus
    Interventions
    Sesame Oil; triamcinolone in orabase
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2019-12-16
    Completion
    2020-12-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Lichen Planus
    InterventionSesame Oil; triamcinolone in orabase
    PhaseEarly phase 1
    Registry statusUnknown

  • The Use of Suprachoroidal Triamcinolone Acetonide to Treat Macular Edema in Retinal Vein Occlusion

    NCT05038072 · start 2019-07-25

    Registered record
    Registry ID
    NCT05038072
    Conditions
    Macular Edema; Retinal Vein Occlusion
    Interventions
    suprachoroidal injection of Triamcinolone Acetonide.
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-07-25
    Completion
    2021-02-28
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMacular Edema; Retinal Vein Occlusion
    Interventionsuprachoroidal injection of Triamcinolone Acetonide.
    PhaseNot applicable
    Registry statusCompleted

  • Ultrasound-guided Intervention and Hand Tenosynovitis in Patients With Diabetes Mellitus

    NCT03789526 · start 2018-12-11

    Registered record
    Registry ID
    NCT03789526
    Conditions
    Ultrasound Guided Injection
    Interventions
    ultrasound guidance
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-12-11
    Completion
    2019-02-01
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUltrasound Guided Injection
    Interventionultrasound guidance
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis

    NCT03467919 · start 2018-04-01

    Registered record
    Registry ID
    NCT03467919
    Conditions
    Osteoarthritis, Knee; Knee Pain
    Interventions
    Micro Fragmented Adipose Tissue; Corticosteroid injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-04-01
    Completion
    2024-10-29
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Knee; Knee Pain
    InterventionMicro Fragmented Adipose Tissue; Corticosteroid injection
    PhasePhase 3
    Registry statusCompleted

  • Kybella With Triamcinolone

    NCT03361176 · start 2018-03-26

    Registered record
    Registry ID
    NCT03361176
    Conditions
    Adiposity
    Interventions
    Injectable sodium deoxycholate; Injectable sodium deoxycholate with Triamcinolone acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-03-26
    Completion
    2018-12-18
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdiposity
    InterventionInjectable sodium deoxycholate; Injectable sodium deoxycholate with Triamcinolone acetate
    PhasePhase 4
    Registry statusCompleted

  • Gene Expression and Biomarker Profiling of Keloid Skin

    NCT03228693 · start 2017-09-11

    Registered record
    Registry ID
    NCT03228693
    Conditions
    Keloid; Keloid of Ear Lobe; Healthy Adults
    Interventions
    Biopsy and/or triamcinolone injection; Excisional Biopsy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-09-11
    Completion
    2023-01-31
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeloid; Keloid of Ear Lobe; Healthy Adults
    InterventionBiopsy and/or triamcinolone injection; Excisional Biopsy
    PhaseNot applicable
    Registry statusCompleted

  • Asthma Research in Children and Adolescents

    NCT04480242 · start 2017-07-26

    Registered record
    Registry ID
    NCT04480242
    Conditions
    Persistent Asthma; Asthma in Children; Asthma Exacerbation
    Interventions
    Inhaled Corticosteroids (ICs); Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist (ICs/LABA); Other treatments; Inhaler device; Regularly monitoring of the Inhalation technique through mobile app
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2017-07-26
    Completion
    2030-12-31
    Enrolment
    525

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPersistent Asthma; Asthma in Children; Asthma Exacerbation
    InterventionInhaled Corticosteroids (ICs); Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist (ICs/LABA); Other treatments; Inhaler device +1 more
    PhaseNot recorded
    Registry statusActive not recruiting

  • Standardized and Modified Corticosteroid Subacromial Injection for Shoulder Impingement Syndrome

    NCT03148353 · start 2017-05-30

    Registered record
    Registry ID
    NCT03148353
    Conditions
    Shoulder Impingement
    Interventions
    Subacromial injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-05-30
    Completion
    2018-10-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShoulder Impingement
    InterventionSubacromial injection
    PhaseNot applicable
    Registry statusCompleted