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AMR Drug RepurposingSmart Screeningresearch prototype

Zonisamide

FDA-approved product (capsule, oral), marketed as Zonegran, Zonisade, Zonisamide.

Registered studies
50+
Lab records
1
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Zonisamide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Epilepsy
  • Focal-onset seizure
  • Partial epilepsy
  • Seizure

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antiepileptics
FDA pharmacologic class
Anti-epileptic Agent FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA22.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli12.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae7.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis82.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 1 of 1 lab record
Open Zonisamide in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Zonisamide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Placebo-controlled Study of Efficacy & Safety of 2 Trough-ranges of Everolimus as Adjunctive Therapy in Patients With Tuberous Sclerosis Complex (TSC) & Refractory Partial-onset Seizures

    NCT01713946 · start 2013-04-29

    Registered record
    Registry ID
    NCT01713946
    Conditions
    Tuberous Sclerosis Complex-associated Refractory Seizures
    Interventions
    RAD001; Placebo; Antiepileptic drug (1 to 3 only); open label RAD001 (only used for post-extension phase)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-04-29
    Completion
    2017-10-25
    Enrolment
    366

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberous Sclerosis Complex-associated Refractory Seizures
    InterventionRAD001; Placebo; Antiepileptic drug (1 to 3 only); open label RAD001 (only used for post-extension phase)
    PhasePhase 3
    Registry statusCompleted

  • Study of Zonisamide in Early Parkinson Disease

    NCT01766128 · start 2013-02

    Registered record
    Registry ID
    NCT01766128
    Conditions
    Parkinson Disease
    Interventions
    Zonisamide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Withdrawn
    Start
    2013-02
    Completion
    2013-02
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParkinson Disease
    InterventionZonisamide; Placebo
    PhasePhase 2 / Phase 3
    Registry statusWithdrawn

  • Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation

    NCT01685996 · start 2012-09

    Registered record
    Registry ID
    NCT01685996
    Conditions
    Nicotine Dependence
    Interventions
    zonisamide; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2012-09
    Completion
    2014-05
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNicotine Dependence
    Interventionzonisamide; placebo
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • A Post-marketing Observational Study Of The Use Of Zonisamide (ZNS) in the Adjunctive Treatment Of Adult Patients With Partial Onset Seizures (Study E2090-E044-410) (ZOOM)

    NCT01830868 · start 2012-03

    Registered record
    Registry ID
    NCT01830868
    Conditions
    Partial Onset Seizures
    Interventions
    Zonisamide tablets
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-03
    Completion
    2013-08
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPartial Onset Seizures
    InterventionZonisamide tablets
    PhaseNot recorded
    Registry statusCompleted

  • Efficacy Trial of Zonisamide for Myoclonus Dystonia

    NCT01806805 · start 2012-02

    Registered record
    Registry ID
    NCT01806805
    Conditions
    Myoclonus Dystonia
    Interventions
    zonegran; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-02
    Completion
    2014-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyoclonus Dystonia
    Interventionzonegran; placebo
    PhasePhase 3
    Registry statusCompleted

  • Systematic Review: Retigabine for Adjunctive Therapy in Partial Epilepsy

    NCT01587339 · start 2010-09

    Registered record
    Registry ID
    NCT01587339
    Conditions
    Epilepsy
    Interventions
    retigabine/ezogabine; lacosamide; zonisamide; pregabalin; eslicarbazepine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-09
    Completion
    2011-07
    Enrolment
    6,498

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    Interventionretigabine/ezogabine; lacosamide; zonisamide; pregabalin +1 more
    PhaseNot recorded
    Registry statusCompleted

  • Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse

    NCT01137890 · start 2010-06

    Registered record
    Registry ID
    NCT01137890
    Conditions
    Cocaine Dependence
    Interventions
    Zonisamide; Placebo; Cocaine Hydrochloride; Neurocognitive and Performance Battery; Smoking Assessments
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2010-06
    Completion
    2013-08
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine Dependence
    InterventionZonisamide; Placebo; Cocaine Hydrochloride; Neurocognitive and Performance Battery +1 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Clinical and Economic Burden of Uncontrolled Epilepsy: Analyses From a Medicaid Database and a Private Health Plan Database

    NCT01390909 · start 2010-05

    Registered record
    Registry ID
    NCT01390909
    Conditions
    Epilepsy
    Interventions
    Anti-epileptic drug (AED)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-05
    Completion
    2011-01
    Enrolment
    12,386

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionAnti-epileptic drug (AED)
    PhaseNot recorded
    Registry statusCompleted

  • Evaluation of the Efficacy and Safety of Adjunctive Zonisamide vs Replacement With Zonisamide of the Last Added Antiepileptic Drug

    NCT01630057 · start 2009-09

    Registered record
    Registry ID
    NCT01630057
    Conditions
    Partial Seizures
    Interventions
    Adjunctive Zonisamide; Replacement with Zonisamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-09
    Completion
    2012-07
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPartial Seizures
    InterventionAdjunctive Zonisamide; Replacement with Zonisamide
    PhasePhase 4
    Registry statusCompleted

  • Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism

    NCT00862563 · start 2009-05

    Registered record
    Registry ID
    NCT00862563
    Conditions
    Alcoholism; Alcohol Dependence; Alcohol Abuse
    Interventions
    Topiramate; Zonisamide; Levetiracetam; Sugar Pill
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-05
    Completion
    2013-08
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholism; Alcohol Dependence; Alcohol Abuse
    InterventionTopiramate; Zonisamide; Levetiracetam; Sugar Pill
    PhasePhase 2
    Registry statusTerminated

  • Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Study)

    NCT00566254 · start 2008-12

    Registered record
    Registry ID
    NCT00566254
    Conditions
    Epilepsy; Paediatric Partial Onset Seizures
    Interventions
    Zonisamide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-12
    Completion
    2011-03
    Enrolment
    207

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy; Paediatric Partial Onset Seizures
    InterventionZonisamide; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Assessing The Long-Term Safety And To Explore The Long-Term Efficacy Of Zonisamide As Monotherapy In Newly Diagnosed Partial Seizures

    NCT00848549 · start 2008-10

    Registered record
    Registry ID
    NCT00848549
    Conditions
    Epilepsy
    Interventions
    Zonisamide; Carbamazepine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-10
    Completion
    2011-11
    Enrolment
    295

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionZonisamide; Carbamazepine
    PhasePhase 3
    Registry statusCompleted

  • Olanzapine Given in Combination With Zonisamide SR to Prevent Weight Gain in Schizophrenic Subjects

    NCT00734435 · start 2008-09

    Registered record
    Registry ID
    NCT00734435
    Conditions
    Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
    Interventions
    zonisamide SR plus olanzapine; Placebo plus olanzapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2008-09
    Completion
    2008-12
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
    Interventionzonisamide SR plus olanzapine; Placebo plus olanzapine
    PhasePhase 2
    Registry statusTerminated

  • Adjunctive Zonisamide in Primary Generalised Tonic Clonic Seizures

    NCT00692003 · start 2008-08-01

    Registered record
    Registry ID
    NCT00692003
    Conditions
    Epilepsy
    Interventions
    Zonisamide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2008-08-01
    Completion
    2009-01-09
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionZonisamide; Placebo
    PhasePhase 3
    Registry statusTerminated

  • A Study of Zonisamide to Prevent Olanzapine-Associated Weight Gain

    NCT00363376 · start 2008-01

    Registered record
    Registry ID
    NCT00363376
    Conditions
    Weight Gain
    Interventions
    zonisamide; olanzapine; Zonisamide; Sugar Pill (placebo)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-01
    Completion
    2011-02
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWeight Gain
    Interventionzonisamide; olanzapine; Zonisamide; Sugar Pill (placebo)
    PhasePhase 3
    Registry statusCompleted