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AMR Drug RepurposingSmart Screeningresearch prototype

Zonisamide

FDA-approved product (capsule, oral), marketed as Zonegran, Zonisade, Zonisamide.

Registered studies
50+
Lab records
1
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Zonisamide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Epilepsy
  • Focal-onset seizure
  • Partial epilepsy
  • Seizure

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antiepileptics
FDA pharmacologic class
Anti-epileptic Agent FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA22.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli12.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae7.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis82.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 1 of 1 lab record
Open Zonisamide in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Zonisamide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Cognitive Side Effects of Commonly Prescribed Medications in Pediatric Migraine

    NCT00777218 · start 2007-08

    Registered record
    Registry ID
    NCT00777218
    Conditions
    Migraine
    Interventions
    propranolol; zonisamide; topiramate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2007-08
    Completion
    2011-07
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    Interventionpropranolol; zonisamide; topiramate
    PhaseNot applicable
    Registry statusWithdrawn

  • Tetra-O-Methyl Nordihydroguaiaretic Acid in Treating Patients With Recurrent High-Grade Glioma

    NCT00404248 · start 2007-01

    Registered record
    Registry ID
    NCT00404248
    Conditions
    Brain and Central Nervous System Tumors
    Interventions
    terameprocol; pharmacological study
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2007-01
    Completion
    2012-02
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBrain and Central Nervous System Tumors
    Interventionterameprocol; pharmacological study
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Assessment of Safety and Efficacy of Therapy for the Prevention of Weight Gain Associated With Olanzapine

    NCT00401973 · start 2006-11

    Registered record
    Registry ID
    NCT00401973
    Conditions
    Schizophrenia; Schizoaffective Disorders
    Interventions
    olanzapine; amantadine; metformin; zonisamide; Wellness education
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-11
    Completion
    2008-09
    Enrolment
    199

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorders
    Interventionolanzapine; amantadine; metformin; zonisamide +1 more
    PhasePhase 3
    Registry statusCompleted

  • The Effects of Zonisamide on Alcohol Dependence

    NCT00406692 · start 2006-11

    Registered record
    Registry ID
    NCT00406692
    Conditions
    Alcoholism
    Interventions
    Zonisamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-11
    Completion
    2009-11
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholism
    InterventionZonisamide
    PhasePhase 2
    Registry statusCompleted

  • Zonisamide vs. Placebo in the Treatment of Alcohol Dependence

    NCT00595556 · start 2006-07

    Registered record
    Registry ID
    NCT00595556
    Conditions
    Alcoholism; Alcohol Abuse; Alcohol Dependence
    Interventions
    zonisamide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-07
    Completion
    2009-05
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholism; Alcohol Abuse; Alcohol Dependence
    Interventionzonisamide; Placebo
    PhasePhase 4
    Registry statusCompleted

  • A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures

    NCT00292461 · start 2006-03

    Registered record
    Registry ID
    NCT00292461
    Conditions
    Epilepsy
    Interventions
    Zonisamide; Lamotrigine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-03
    Completion
    2009-09
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionZonisamide; Lamotrigine
    PhasePhase 3
    Registry statusCompleted

  • Low and High Dose Zonisamide in Children as Monotherapy

    NCT01127165 · start 2006-03

    Registered record
    Registry ID
    NCT01127165
    Conditions
    Epilepsy
    Interventions
    zonisamide low dose group; zonisamide high dose group
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-03
    Completion
    2009-07
    Enrolment
    125

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    Interventionzonisamide low dose group; zonisamide high dose group
    PhasePhase 4
    Registry statusCompleted

  • Zonisamide for Weight Reduction in Obese Adults

    NCT00275834 · start 2006-01

    Registered record
    Registry ID
    NCT00275834
    Conditions
    Obesity
    Interventions
    Zonisamide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-01
    Completion
    2011-09
    Enrolment
    225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionZonisamide
    PhaseNot applicable
    Registry statusCompleted

  • Open Label, Zonegran (Zonisamide) In Partial Onset Seizures

    NCT00215592 · start 2005-10

    Registered record
    Registry ID
    NCT00215592
    Conditions
    Epilepsy
    Interventions
    Zonegran
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-10
    Completion
    Not recorded
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionZonegran
    PhasePhase 4
    Registry statusCompleted

  • A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies

    NCT00154076 · start 2005-09

    Registered record
    Registry ID
    NCT00154076
    Conditions
    Epilepsy
    Interventions
    Zonisamide; Topiramate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-09
    Completion
    2008-12
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionZonisamide; Topiramate
    PhasePhase 4
    Registry statusCompleted

  • Efficacy and Safety of an add-on Treatment With Zonisamide in Adults With Focal Epileptic Seizures With or Without Secondary Generalization

    NCT00165828 · start 2005-05

    Registered record
    Registry ID
    NCT00165828
    Conditions
    Epilepsy
    Interventions
    Zonegran
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2005-05
    Completion
    2008-02
    Enrolment
    157

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionZonegran
    PhasePhase 4
    Registry statusTerminated

  • Fed Bioavailability Study of Zonisamide Capsules

    NCT00687167 · start 2005-01

    Registered record
    Registry ID
    NCT00687167
    Conditions
    Healthy
    Interventions
    Zonisamide 100 mg Capsule; Zonisamide (Zonegran®) 100 mg Capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2005-01
    Completion
    2005-03
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionZonisamide 100 mg Capsule; Zonisamide (Zonegran®) 100 mg Capsule
    PhasePhase 1
    Registry statusCompleted

  • Bioequivalence Study of Zonisamide Capsules 100 mg of Dr.Reddy's Laboratories Limited Under Fed Conditions

    NCT01161979 · start 2005-01

    Registered record
    Registry ID
    NCT01161979
    Conditions
    Healthy
    Interventions
    Zonisamide; Zonegran
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2005-01
    Completion
    2005-03
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionZonisamide; Zonegran
    PhasePhase 1
    Registry statusCompleted

  • A Safety/Efficacy Trial of Zonisamide for Essential Tremor

    NCT00223743 · start 2004-11

    Registered record
    Registry ID
    NCT00223743
    Conditions
    Essential Tremor
    Interventions
    Zonisamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-11
    Completion
    Not recorded
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Tremor
    InterventionZonisamide
    PhasePhase 2
    Registry statusCompleted

  • Zonisamide for Fibromyalgia & Migraine

    NCT00259636 · start 2004-08

    Registered record
    Registry ID
    NCT00259636
    Conditions
    Fibromyalgia; Migraine
    Interventions
    zonisamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2004-08
    Completion
    2008-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFibromyalgia; Migraine
    Interventionzonisamide
    PhasePhase 4
    Registry statusWithdrawn