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AMR Drug RepurposingSmart Screeningresearch prototype

Streptomycin Sulfate

FDA-approved product (injectable, injection), marketed as Streptomycin Sulfate.

Registered studies
32
Lab records
63
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Streptomycin Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Chancroid
  • Granuloma inguinale
  • Infection
  • Pneumonia
  • Septicemic plague
  • Tuberculosis
  • Tularemia
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antibiotics; Streptomycins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01GA01; WHO ATC A07AA04; WHO ATC A07AA54

Repurposing investigation

Streptomycin Sulfate is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA74.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli71.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae75.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis87.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

32registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 4 of 4 lab records
  • K. pneumoniae: measured active in 15 of 15 lab records
  • M. tuberculosis: measured active in 41 of 42 lab records
Open Streptomycin Sulfate in ChEMBL Registered studies below
Show the 63 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Streptomycin Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Clinical Trial to Investigate the Pharmacokinetics of Second-Line Anti-Tuberculosis Agents

    NCT02128308 · start 2013-11

    Registered record
    Registry ID
    NCT02128308
    Conditions
    Healthy
    Interventions
    Levofloxacin and Streptomycin added; Moxifloxacin and Kanamycin added
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-11
    Completion
    2014-01
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionLevofloxacin and Streptomycin added; Moxifloxacin and Kanamycin added
    PhasePhase 1
    Registry statusCompleted

  • Research on New Regimens for Retreatment Pulmonary Tuberculosis

    NCT02331823 · start 2013-06

    Registered record
    Registry ID
    NCT02331823
    Conditions
    Reinfection Pulmonary Tuberculosis
    Interventions
    Isoniazid Aminosalicylate Tablets; Streptomycin injectable
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-06
    Completion
    2016-12
    Enrolment
    864

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionReinfection Pulmonary Tuberculosis
    InterventionIsoniazid Aminosalicylate Tablets; Streptomycin injectable
    PhasePhase 4
    Registry statusUnknown

  • WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8

    NCT01659437 · start 2012-12

    Registered record
    Registry ID
    NCT01659437
    Conditions
    Mycobacterium Ulcerans Infection
    Interventions
    Clarithromycin Extended Release; Streptomycin intramuscular injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2012-12
    Completion
    2018-01
    Enrolment
    310

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMycobacterium Ulcerans Infection
    InterventionClarithromycin Extended Release; Streptomycin intramuscular injection
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin

    NCT02604849 · start 2012-07

    Registered record
    Registry ID
    NCT02604849
    Conditions
    Patients Colonized by Klebsiella Pneumoniae.
    Interventions
    Neomycin; Streptomycin; Gentamicins
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-07
    Completion
    2015-11
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatients Colonized by Klebsiella Pneumoniae.
    InterventionNeomycin; Streptomycin; Gentamicins
    PhaseNot recorded
    Registry statusCompleted

  • Timing of Surgical Intervention in Buruli Ulcer Patients Treated With Antibiotics

    NCT01432925 · start 2011-09

    Registered record
    Registry ID
    NCT01432925
    Conditions
    Mycobacterium Ulcerans Disease; Buruli Ulcer
    Interventions
    surgical intervention on Buruli ulcer
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-09
    Completion
    2016-12
    Enrolment
    119

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMycobacterium Ulcerans Disease; Buruli Ulcer
    Interventionsurgical intervention on Buruli ulcer
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy and Safety of Qinbudan as an Adjunct Therapy for Retreatment Pulmonary Tuberculosis

    NCT02313610 · start 2011-04

    Registered record
    Registry ID
    NCT02313610
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Qinbudan; Qinbudan Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-04
    Completion
    2013-03
    Enrolment
    253

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionQinbudan; Qinbudan Placebo
    PhasePhase 2
    Registry statusCompleted

  • Prophylatic Effect Preoperative Antibiotics With Mechanical Bowel Preparation in SSIs: A Propensity Analysis

    NCT04258098 · start 2011-01-01

    Registered record
    Registry ID
    NCT04258098
    Conditions
    Surgical Site Infection; Colorectal Cancer
    Interventions
    Oral antibiotics ( Streptomycin ,metronidazole )
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-01-01
    Completion
    2019-05-12
    Enrolment
    806

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection; Colorectal Cancer
    InterventionOral antibiotics ( Streptomycin ,metronidazole )
    PhaseNot recorded
    Registry statusCompleted

  • Nontypeable H. Influenzae in Healthy Adults

    NCT00905385 · start 2009-08

    Registered record
    Registry ID
    NCT00905385
    Conditions
    Haemophilus Influenzae (NTHI)
    Interventions
    NTHi Strain 2019
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2009-08
    Completion
    2011-03
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHaemophilus Influenzae (NTHI)
    InterventionNTHi Strain 2019
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Directly Observed Therapy Short Course-Plus Versus DOTS for Retreatment of Relapsed Pulmonary Tuberculosis in Guangzhou

    NCT01618422 · start 2009-03

    Registered record
    Registry ID
    NCT01618422
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Directly Observed Therapy (DOTS) plus; Directly Observed Therapy (DOTS)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-03
    Completion
    2014-02
    Enrolment
    225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionDirectly Observed Therapy (DOTS) plus; Directly Observed Therapy (DOTS)
    PhaseNot applicable
    Registry statusCompleted

  • Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis

    NCT00816426 · start 2008-12-29

    Registered record
    Registry ID
    NCT00816426
    Conditions
    Tuberculosis
    Interventions
    Rifampicin; Isoniazid; Pyrazinamide; Kanamycin; Moxifloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-12-29
    Completion
    2017-12-29
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis
    InterventionRifampicin; Isoniazid; Pyrazinamide; Kanamycin +1 more
    PhasePhase 1
    Registry statusCompleted

  • Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146 CARINEMO)

    NCT00495326 · start 2007-12

    Registered record
    Registry ID
    NCT00495326
    Conditions
    Tuberculosis; Aids; Hiv Infections
    Interventions
    Nevirapine based therapy; Efavirenz based therapy; Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2007-12
    Completion
    2011-04
    Enrolment
    570

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis; Aids; Hiv Infections
    InterventionNevirapine based therapy; Efavirenz based therapy; Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • BURULICO Drug Trial Study Protocol: RCT SR8/SR4+CR4, GHANA

    NCT00321178 · start 2006-05

    Registered record
    Registry ID
    NCT00321178
    Conditions
    Buruli Ulcer; Mycobacterium Ulcerans
    Interventions
    SR4 - switch to CR4
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2006-05
    Completion
    2009-02
    Enrolment
    151

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBuruli Ulcer; Mycobacterium Ulcerans
    InterventionSR4 - switch to CR4
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Safety and Immunogenicity of Various Formulations of Live Attenuated Tetravalent Dengue Vaccine in Healthy US Adults

    NCT00350337 · start 2006-04-05

    Registered record
    Registry ID
    NCT00350337
    Conditions
    Dengue
    Interventions
    Pre-transfection F17; Post-transfection F17; Post-transfection F19; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-04-05
    Completion
    2008-03-13
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDengue
    InterventionPre-transfection F17; Post-transfection F17; Post-transfection F19; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Treatment and Diagnosis of Plague

    NCT00128466 · start 2004-08

    Registered record
    Registry ID
    NCT00128466
    Conditions
    Plague
    Interventions
    gentamicin; streptomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2004-08
    Completion
    2007-02
    Enrolment
    114

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlague
    Interventiongentamicin; streptomycin
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Pilot Randomized Study of Paromomycin (Aminosidine) vs Streptomycin for Uncomplicated Pulmonary Tuberculosis

    NCT00004444 · start 1994-11

    Registered record
    Registry ID
    NCT00004444
    Conditions
    Tuberculosis, Pulmonary
    Interventions
    paromomycin; streptomycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    1994-11
    Completion
    2001-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTuberculosis, Pulmonary
    Interventionparomomycin; streptomycin
    PhaseNot applicable
    Registry statusCompleted