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AMR Drug RepurposingSmart Screeningresearch prototype

Clindamycin Phosphate

FDA-approved product (injectable, injection), marketed as Cleocin, Cleocin Phosphate, Cleocin Phosphate In Dextrose 5% In Plastic Container and 12 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Clindamycin Phosphate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Abdominal abscess
  • Abscess
  • Acne
  • Bacterial disease
  • Bacterial vaginosis
  • Empyema
  • Endometritis
  • Female reproductive system disease
  • Infection
  • Irritable bowel syndrome
  • Lung Abscess
  • Osteomyelitis
  • Parametritis
  • Peritonitis
  • Pneumonia
  • Pseudomembranous enterocolitis
  • and 3 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives for treatment of acne; Antibiotics; Lincosamides
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC D10AF01; WHO ATC J01FF01; WHO ATC G01AA10

Repurposing investigation

Clindamycin Phosphate is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA58.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli18.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae19.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis27.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Clindamycin Phosphate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clindamycin Phosphate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Does Antibiotic Prophylaxis Reduce Wound Complications After Vulvar Excision of Premalignant Lesions

    NCT03578965 · start 2018-07-13

    Registered record
    Registry ID
    NCT03578965
    Conditions
    Premalignant Vulvar Lesion; Benign Vulvar Lesion
    Interventions
    Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2018-07-13
    Completion
    2021-11-23
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPremalignant Vulvar Lesion; Benign Vulvar Lesion
    InterventionCefazolin
    PhasePhase 2
    Registry statusCompleted

  • A Randomized, Controlled Trial of the Effectiveness of Perioperative Antibiotics for Reduction of Burn Wound Bacterial Concentration Following Grafting

    NCT04516148 · start 2018-05-29

    Registered record
    Registry ID
    NCT04516148
    Conditions
    Burn; Surgery; Infection Wound
    Interventions
    Cefazolin; Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-05-29
    Completion
    2020-10-30
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurn; Surgery; Infection Wound
    InterventionCefazolin; Clindamycin
    PhasePhase 4
    Registry statusCompleted

  • Antibiotics During Intrauterine Balloon Tamponade Placement

    NCT03478163 · start 2018-03-08

    Registered record
    Registry ID
    NCT03478163
    Conditions
    Obstetric Complication; Postpartum Hemorrhage; Postpartum Endometritis
    Interventions
    CeFAZolin 1000 MG; Clindamycin 900 MG in 6 ML Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2018-03-08
    Completion
    2021-05-03
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObstetric Complication; Postpartum Hemorrhage; Postpartum Endometritis
    InterventionCeFAZolin 1000 MG; Clindamycin 900 MG in 6 ML Injection
    PhasePhase 4
    Registry statusTerminated

  • Chlorhexidine Vaginal Cleansing Versus Iodine Prior to C-section and the Rate of Postoperative Infection

    NCT03431701 · start 2018-02-08

    Registered record
    Registry ID
    NCT03431701
    Conditions
    Vaginal Scrubbing
    Interventions
    Chlorhexidine; Iodine; Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-02-08
    Completion
    2019-06-30
    Enrolment
    333

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaginal Scrubbing
    InterventionChlorhexidine; Iodine; Antibiotics
    PhaseNot applicable
    Registry statusCompleted

  • Peritonsillar Abscess: Aspiration Versus Tonsillectomy a Chaud

    NCT03326661 · start 2017-11-10

    Registered record
    Registry ID
    NCT03326661
    Conditions
    Peritonsillar Abscess
    Interventions
    Aspiration; Tonsillectomy a chaud; Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-11-10
    Completion
    2020-11-30
    Enrolment
    128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeritonsillar Abscess
    InterventionAspiration; Tonsillectomy a chaud; Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
    PhaseNot applicable
    Registry statusUnknown

  • Antibiotics Usage in Pediatric Orthopaedic Percutaneous Surgery (APOPS)

    NCT03261830 · start 2017-08-18

    Registered record
    Registry ID
    NCT03261830
    Conditions
    Supracondylar Humerus Fracture; Post Operative Wound Infection
    Interventions
    Cefazolin; Clindamycin; Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-08-18
    Completion
    2023-03-10
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSupracondylar Humerus Fracture; Post Operative Wound Infection
    InterventionCefazolin; Clindamycin; Saline
    PhasePhase 4
    Registry statusCompleted

  • Target Attainment and Pharmacokinetics of Antimicrobials in Non-critically Ill Surgery Patients (TAPAS)

    NCT03120663 · start 2016-11-30

    Registered record
    Registry ID
    NCT03120663
    Conditions
    Surgery
    Interventions
    amoxicillin-clavulanic acid
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2016-11-30
    Completion
    2018-09-30
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgery
    Interventionamoxicillin-clavulanic acid
    PhaseNot recorded
    Registry statusUnknown

  • Oral Probiotics for the Treatment and Prevention of Vulvovaginal Infections in Pregnancy - Double-blind, Randomized, Placebo-controlled Study

    NCT02795845 · start 2016-11

    Registered record
    Registry ID
    NCT02795845
    Conditions
    Bacterial Vaginosis and Vaginal Candidiasis At Pregnancy
    Interventions
    Probiotic Capsule containing L. acidophilus, L. Paracasei, L. Rhamnosus, streptococcus thermophilus and Bifidobacterium bifidum; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-11
    Completion
    2021-08
    Enrolment
    157

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Vaginosis and Vaginal Candidiasis At Pregnancy
    InterventionProbiotic Capsule containing L. acidophilus, L. Paracasei, L. Rhamnosus, streptococcus thermophilus and Bifidobacterium bifidum; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Vaginal Clindamycin Cream Plus Vaginal Probiotic for Bacterial Vaginosis

    NCT03234517 · start 2016-08-01

    Registered record
    Registry ID
    NCT03234517
    Conditions
    Bacterial Vaginosis Treatment
    Interventions
    Vaginal Clindamycin Cream; Vaginal Probiotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2016-08-01
    Completion
    2018-08
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Vaginosis Treatment
    InterventionVaginal Clindamycin Cream; Vaginal Probiotic
    PhasePhase 2
    Registry statusUnknown

  • The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis

    NCT03080740 · start 2016-07

    Registered record
    Registry ID
    NCT03080740
    Conditions
    Bacterial Vaginosis
    Interventions
    Clindamycin palmitate hydrochloride dispersible tablet; Metronidazole Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-07
    Completion
    2017-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Vaginosis
    InterventionClindamycin palmitate hydrochloride dispersible tablet; Metronidazole Tablet
    PhasePhase 4
    Registry statusUnknown

  • Effect of Concomitant Use of an Antimycotic, an Antibiotic, a Spermicide or Tampons on Pharmacokinetics of Anastrozole and Levonorgestrel Released From Intra-vaginal Ring

    NCT02545452 · start 2015-09-15

    Registered record
    Registry ID
    NCT02545452
    Conditions
    Endometriosis
    Interventions
    Anastrozole / Levonorgestrel (BAY98-7196); Gyno-Daktarin; Sobelin vaginal creme; Patentex oval; Tampon
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-09-15
    Completion
    2016-07-29
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometriosis
    InterventionAnastrozole / Levonorgestrel (BAY98-7196); Gyno-Daktarin; Sobelin vaginal creme; Patentex oval +1 more
    PhasePhase 1
    Registry statusCompleted

  • Validation of the Jawbone Anatomy Classification in Endosseous Dental Implant Treatment

    NCT02054676 · start 2014-02

    Registered record
    Registry ID
    NCT02054676
    Conditions
    Partially Edentulous Jaw
    Interventions
    Cone-Beam Computed Tomography preoperative evaluation.; Intraoperative edentulous jaw segment parameters evaluation.; Endosseous dental implant placement.; Dental implant position evaluation.; Medications.; Late postoperative soft tissue evaluation.
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2014-02
    Completion
    2016-04
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPartially Edentulous Jaw
    InterventionCone-Beam Computed Tomography preoperative evaluation.; Intraoperative edentulous jaw segment parameters evaluation.; Endosseous dental implant placement.; Dental implant position evaluation. +2 more
    PhaseNot applicable
    Registry statusUnknown

  • Clindamycin to Reduce Preterm Birth in a Low Resource Setting

    NCT01800825 · start 2013-07

    Registered record
    Registry ID
    NCT01800825
    Conditions
    Pregnancy; Prematurity; Preterm Birth; Bacterial Vaginosis
    Interventions
    Clindamycin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-07
    Completion
    2016-04
    Enrolment
    1,726

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy; Prematurity; Preterm Birth; Bacterial Vaginosis
    InterventionClindamycin; Placebo
    PhasePhase 4
    Registry statusCompleted

  • AUGMENTIN™ in Dental Infections

    NCT02141217 · start 2013-03-21

    Registered record
    Registry ID
    NCT02141217
    Conditions
    Focal Infection, Dental
    Interventions
    Amoxicillin/clavulanate; Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-03-21
    Completion
    2013-12-28
    Enrolment
    472

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFocal Infection, Dental
    InterventionAmoxicillin/clavulanate; Clindamycin
    PhasePhase 4
    Registry statusCompleted

  • Gentamicin Versus Clindamycin Versus Normal Saline Lavage in Axilla

    NCT02314806 · start 2013-01

    Registered record
    Registry ID
    NCT02314806
    Conditions
    Breast Cancer
    Interventions
    Irrigation with gentamicin solution; Irrigation with Clindamycin solution; Irrigation with Normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-01
    Completion
    2014-12
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionIrrigation with gentamicin solution; Irrigation with Clindamycin solution; Irrigation with Normal saline
    PhasePhase 3
    Registry statusCompleted