Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Clindamycin Phosphate

FDA-approved product (injectable, injection), marketed as Cleocin, Cleocin Phosphate, Cleocin Phosphate In Dextrose 5% In Plastic Container and 12 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Clindamycin Phosphate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Abdominal abscess
  • Abscess
  • Acne
  • Bacterial disease
  • Bacterial vaginosis
  • Empyema
  • Endometritis
  • Female reproductive system disease
  • Infection
  • Irritable bowel syndrome
  • Lung Abscess
  • Osteomyelitis
  • Parametritis
  • Peritonitis
  • Pneumonia
  • Pseudomembranous enterocolitis
  • and 3 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives for treatment of acne; Antibiotics; Lincosamides
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC D10AF01; WHO ATC J01FF01; WHO ATC G01AA10

Repurposing investigation

Clindamycin Phosphate is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA58.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli18.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae19.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis27.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Clindamycin Phosphate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clindamycin Phosphate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies

    NCT01722708 · start 2012-11-01

    Registered record
    Registry ID
    NCT01722708
    Conditions
    Abnormal Vaginal Flora; Clindamycin Vs Metronidazole; High Risk Pregnancies for Preterm Labor
    Interventions
    Clindamycin; Metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-11-01
    Completion
    2025-12-30
    Enrolment
    166

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbnormal Vaginal Flora; Clindamycin Vs Metronidazole; High Risk Pregnancies for Preterm Labor
    InterventionClindamycin; Metronidazole
    PhaseNot applicable
    Registry statusCompleted

  • Study Comparing Clindamycin Phosphate and Benzoyl Peroxide Gel to Acanya® Gel and Both to a Vehicle Control in the Treatment of Acne Vulgaris

    NCT01769235 · start 2012-11

    Registered record
    Registry ID
    NCT01769235
    Conditions
    Acne Vulgaris
    Interventions
    Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5%; Acanya® Gel, 1.2%/2.5%; Vehicle of test product
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-11
    Completion
    2013-12
    Enrolment
    1,215

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionClindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5%; Acanya® Gel, 1.2%/2.5%; Vehicle of test product
    PhasePhase 1
    Registry statusCompleted

  • Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection

    NCT01757236 · start 2012-10

    Registered record
    Registry ID
    NCT01757236
    Conditions
    Hip Prosthetic Joint Infection
    Interventions
    VANCOMYCIN; CEFTRIAXONE; CLINDAMYCIN; SULFAMETHOXAZOLE AND TRIMETHOPRIM (CO-TRIMOXAZOLE); FLUOROQUINOLONE; LINEZOLID; RIFAMPIN
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2012-10
    Completion
    2016-04
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Prosthetic Joint Infection
    InterventionVANCOMYCIN; CEFTRIAXONE; CLINDAMYCIN; SULFAMETHOXAZOLE AND TRIMETHOPRIM (CO-TRIMOXAZOLE) +3 more
    PhasePhase 2
    Registry statusUnknown

  • Evaluate Therapeutic Equivalence and Safety of Two Clindamycin Phosphate and Benzoyl Peroxide Gels in Acne Vulgaris

    NCT01788384 · start 2012-07

    Registered record
    Registry ID
    NCT01788384
    Conditions
    Acne Vulgaris
    Interventions
    Clindamycin Phosphate / Benzoyl Peroxide Gel; Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5%; Placebo (Vehicle Gel)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-07
    Completion
    2012-12
    Enrolment
    708

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionClindamycin Phosphate / Benzoyl Peroxide Gel; Clindamycin Phosphate and Benzoyl Peroxide Gel, 1.2%/2.5%; Placebo (Vehicle Gel)
    PhasePhase 3
    Registry statusCompleted

  • Study STF115287, a Clinical Confirmation Study of GSK2585823 in the Treatment of Acne Vulgaris in Japanese Subjects

    NCT01445301 · start 2011-09-27

    Registered record
    Registry ID
    NCT01445301
    Conditions
    Acne Vulgaris
    Interventions
    GSK2585823(CLDM 1%-BPO 3% gel); CLDM 1% gel twice daily
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-09-27
    Completion
    2012-08-02
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionGSK2585823(CLDM 1%-BPO 3% gel); CLDM 1% gel twice daily
    PhasePhase 3
    Registry statusCompleted

  • The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery

    NCT01912651 · start 2011-09-22

    Registered record
    Registry ID
    NCT01912651
    Conditions
    Facial Defect
    Interventions
    cephalexin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-09-22
    Completion
    2025-11-07
    Enrolment
    236

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFacial Defect
    Interventioncephalexin
    PhasePhase 4
    Registry statusCompleted

  • Clinical Evaluation of a New Form of Cancer Therapy (Atavistic Chemotherapy) Based on the Principles of Atavistic Metamorphosis (2011)

    NCT02366884 · start 2011-07-26

    Registered record
    Registry ID
    NCT02366884
    Conditions
    Neoplasms
    Interventions
    Anti-Bacterial Agents; Anti-Fungal Agents; Anti-Protozoal Agents
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2011-07-26
    Completion
    2023-12-31
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeoplasms
    InterventionAnti-Bacterial Agents; Anti-Fungal Agents; Anti-Protozoal Agents
    PhasePhase 2
    Registry statusUnknown

  • Study STF115288, a Clinical Confirmation Study of GI148512 in the Treatment of Acne Vulgaris in Japanese Subjects

    NCT01400932 · start 2011-07

    Registered record
    Registry ID
    NCT01400932
    Conditions
    Acne Vulgaris
    Interventions
    GI148512; vehicle gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-07
    Completion
    2012-04
    Enrolment
    360

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionGI148512; vehicle gel
    PhasePhase 3
    Registry statusCompleted

  • Japanese Phase 1 Study of GSK2585823

    NCT01428466 · start 2010-11-18

    Registered record
    Registry ID
    NCT01428466
    Conditions
    Acne Vulgaris
    Interventions
    GSK2585823; Benzoyl peroxide 3%; Benzoyl peroxide 5%; Vehicle
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-11-18
    Completion
    2011-02-15
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionGSK2585823; Benzoyl peroxide 3%; Benzoyl peroxide 5%; Vehicle
    PhasePhase 1
    Registry statusCompleted

  • Antibiotic Prophylaxis for Simple Hand Lacerations

    NCT01155154 · start 2010-02

    Registered record
    Registry ID
    NCT01155154
    Conditions
    Simple Hand Lacerations
    Interventions
    cephalexin; clindamycin; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-02
    Completion
    2012-02
    Enrolment
    73

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSimple Hand Lacerations
    Interventioncephalexin; clindamycin; placebo
    PhaseNot applicable
    Registry statusTerminated

  • Compare the Tolerance of Clindamycin 1% /Benzoyl Peroxide (BPO) 5% Gel to Clindamycin 1.2%/ BPO 2.5% Topical Medications

    NCT01015638 · start 2009-08

    Registered record
    Registry ID
    NCT01015638
    Conditions
    Acne Vulgaris
    Interventions
    Clindamycin and BPO 5% gel; Clindamycin phosphate and benzoyl peroxide 2.5% gel.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-08
    Completion
    2009-09
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionClindamycin and BPO 5% gel; Clindamycin phosphate and benzoyl peroxide 2.5% gel.
    PhasePhase 4
    Registry statusCompleted

  • A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne

    NCT00964223 · start 2009-07

    Registered record
    Registry ID
    NCT00964223
    Conditions
    Acne Vulgaris
    Interventions
    Clindamycin and benzoyl peroxide gel (Duac® Topical Gel); benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07
    Completion
    2009-11
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionClindamycin and benzoyl peroxide gel (Duac® Topical Gel); benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
    PhasePhase 4
    Registry statusCompleted

  • Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications

    NCT00964366 · start 2009-07

    Registered record
    Registry ID
    NCT00964366
    Conditions
    Acne Vulgaris
    Interventions
    clindamycin and benzoyl peroxide; Dapsone gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07
    Completion
    2009-08
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    Interventionclindamycin and benzoyl peroxide; Dapsone gel
    PhasePhase 4
    Registry statusCompleted

  • Systemic and Topical Treatments for Rash Secondary to Erlotinib in Lung Cancer

    NCT00473083 · start 2009-01

    Registered record
    Registry ID
    NCT00473083
    Conditions
    Rash
    Interventions
    Minocycline; Clindamycin 2% in hydrocortisone 1% lotion; Erlotinib; Topical clindamycin 2%, triamcinolone acetonide 0.1% soln
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-01
    Completion
    2013-08
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRash
    InterventionMinocycline; Clindamycin 2% in hydrocortisone 1% lotion; Erlotinib; Topical clindamycin 2%, triamcinolone acetonide 0.1% soln
    PhasePhase 2
    Registry statusCompleted

  • W0265-103: A Single-Center, Evaluator-Blinded, Randomized, Placebo Controlled, Phase 1 Clinical Trial Evaluating The Phototoxic Potential Of Topically Applied Clindamycin 1.0% - Tretinoin 0.025% Gel (Ct Gel) In Healthy Volunteers

    NCT01929278 · start 2008-12-08

    Registered record
    Registry ID
    NCT01929278
    Conditions
    Acne Vulgaris
    Interventions
    CT Gel (clindamycin 1% and tretinoin 0.025%); Vehicle gel patch; Blank patch
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-12-08
    Completion
    2008-12-19
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionCT Gel (clindamycin 1% and tretinoin 0.025%); Vehicle gel patch; Blank patch
    PhasePhase 1
    Registry statusCompleted