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AMR Drug RepurposingSmart Screeningresearch prototype

Estradiol Cypionate

FDA-approved product (injectable, injection), marketed as Depo-Estradiol, Estradiol Cypionate.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Estradiol Cypionate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Atrophic Vaginitis
  • Atrophy
  • Breast cancer
  • Breast carcinoma
  • Breast neoplasm
  • Dyspareunia
  • Hypogonadism
  • Menopause
  • Osteoporosis
  • Postmenopausal atrophic vaginitis
  • Postmenopausal osteoporosis
  • Premature ovarian insufficiency
  • Primary ovarian insufficiency

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Natural and semisynthetic estrogens, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA56.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli31.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae23.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis25.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Estradiol Cypionate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-10.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-10.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Estradiol Cypionate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Cabergoline and Coasting to Prevent OHSS

    NCT01984320 · start 2013-10

    Registered record
    Registry ID
    NCT01984320
    Conditions
    OHSS
    Interventions
    ICSI
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-10
    Completion
    2015-07
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOHSS
    InterventionICSI
    PhaseNot applicable
    Registry statusCompleted

  • Acupuncture for Relieving Perimenopausal Symptoms

    NCT01933204 · start 2013-09

    Registered record
    Registry ID
    NCT01933204
    Conditions
    Perimenopause
    Interventions
    Acupuncture; Climen 21 Tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2013-09
    Completion
    2015-08
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerimenopause
    InterventionAcupuncture; Climen 21 Tablets
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved (Frozen)-Thawed Day 3 Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone

    NCT01940653 · start 2012-11

    Registered record
    Registry ID
    NCT01940653
    Conditions
    Progesterone Supplementation
    Interventions
    Progesterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-11
    Completion
    2017-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProgesterone Supplementation
    InterventionProgesterone
    PhasePhase 4
    Registry statusCompleted

  • NuvaRing Versus Marvelon in the Coordination of In Vitro Fertilization Cycles

    NCT01638767 · start 2012-07

    Registered record
    Registry ID
    NCT01638767
    Conditions
    Infertility
    Interventions
    Contraceptives, Oral; Contraceptive, Vaginal ring
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2012-07
    Completion
    2014-07
    Enrolment
    7

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionContraceptives, Oral; Contraceptive, Vaginal ring
    PhasePhase 4
    Registry statusTerminated

  • HCG (Human Chorionic Gonadotropin) Priming for Thin Endometrium in IVF (in Vitro Fertilization)

    NCT01768247 · start 2012-01

    Registered record
    Registry ID
    NCT01768247
    Conditions
    Endometrial Thickness; Pregnancy Outcome
    Interventions
    HCG (human chorionic gonadotropin)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-01
    Completion
    2014-01
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometrial Thickness; Pregnancy Outcome
    InterventionHCG (human chorionic gonadotropin)
    PhasePhase 4
    Registry statusUnknown

  • A Study of LY2216684 in Healthy Females

    NCT01373931 · start 2011-06

    Registered record
    Registry ID
    NCT01373931
    Conditions
    Depressive Disorder, Major
    Interventions
    LY2216684; Ortho Cyclen; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-06
    Completion
    2011-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepressive Disorder, Major
    InterventionLY2216684; Ortho Cyclen; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients

    NCT01353846 · start 2011-05

    Registered record
    Registry ID
    NCT01353846
    Conditions
    Infertility
    Interventions
    observation natural cycle; Agonist GnRH; estradiol Valerate; progesterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-05
    Completion
    2012-11
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    Interventionobservation natural cycle; Agonist GnRH; estradiol Valerate; progesterone
    PhasePhase 4
    Registry statusUnknown

  • Drug-drug Interaction of Empagliflozin (BI 10773) and Microgynon

    NCT01328184 · start 2011-04

    Registered record
    Registry ID
    NCT01328184
    Conditions
    Healthy
    Interventions
    levonorgestrel; levonorgestrel; Ethinylestradiol; Microgynon + BI 10773; Ethinylestradiol
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-04
    Completion
    Not recorded
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionlevonorgestrel; levonorgestrel; Ethinylestradiol; Microgynon + BI 10773 +1 more
    PhasePhase 1
    Registry statusCompleted

  • Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles

    NCT01668446 · start 2009-09

    Registered record
    Registry ID
    NCT01668446
    Conditions
    Endometrial Preparation; Frozen Embryo Transfer
    Interventions
    Sildenafil; estradiol valerat
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-09
    Completion
    2011-02
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometrial Preparation; Frozen Embryo Transfer
    InterventionSildenafil; estradiol valerat
    PhasePhase 4
    Registry statusCompleted

  • A Pharmacokinetic Evaluation of Bioidentical Compounded Estrogen Cream and Natural Progesterone

    NCT00864214 · start 2008-06

    Registered record
    Registry ID
    NCT00864214
    Conditions
    Menopause
    Interventions
    bioidentical hormone (Biest); bioidentical hormone (Biest); bioidentical hormone (Biest); bioidentical hormone (Vivelle-Dot)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-06
    Completion
    2010-04
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMenopause
    Interventionbioidentical hormone (Biest); bioidentical hormone (Biest); bioidentical hormone (Biest); bioidentical hormone (Vivelle-Dot)
    PhasePhase 1
    Registry statusCompleted

  • Combined Hormone Therapy, C-reactive Protein(CRP) Levels and Life Quality in Natural Menopause Women

    NCT04424173 · start 2007-08-01

    Registered record
    Registry ID
    NCT04424173
    Conditions
    CRP; Menopause
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-08-01
    Completion
    2008-08-30
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCRP; Menopause
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • AZD2171 in Addition to Fulvestrant in Patients With Advanced Breast Cancer.

    NCT00454805 · start 2007-03

    Registered record
    Registry ID
    NCT00454805
    Conditions
    Advanced Breast Cancer
    Interventions
    AZD2171; Fulvestrant
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-03
    Completion
    2016-04
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdvanced Breast Cancer
    InterventionAZD2171; Fulvestrant
    PhasePhase 2
    Registry statusCompleted

  • Study Of CP-751,871 In Combination With Exemestane In Postmenopausal Women With Hormone Receptor Positive Advanced Breast Cancer

    NCT00372996 · start 2007-02

    Registered record
    Registry ID
    NCT00372996
    Conditions
    Breast Neoplasms
    Interventions
    CP-751,871; exemestane; exemestane; Fulvestrant
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2007-02
    Completion
    2014-06
    Enrolment
    219

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Neoplasms
    InterventionCP-751,871; exemestane; exemestane; Fulvestrant
    PhasePhase 2
    Registry statusTerminated

  • Bioidentical 'Natural' Hormone Evaluation in Early Menopause

    NCT00302731 · start 2006-02

    Registered record
    Registry ID
    NCT00302731
    Conditions
    Menopause
    Interventions
    Estradiol , estriol , progesterone; estradiol, progesterone; estriol, progesterone; equine estrogens m-progesteroneacetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2006-02
    Completion
    2014-09
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMenopause
    InterventionEstradiol , estriol , progesterone; estradiol, progesterone; estriol, progesterone; equine estrogens m-progesteroneacetate
    PhasePhase 2
    Registry statusTerminated

  • A Study to Evaluate Suppression of the Pituitary-Ovarian Axis With Three Different Oral Contraceptive Regimens

    NCT00117273 · start 2005-06

    Registered record
    Registry ID
    NCT00117273
    Conditions
    Healthy
    Interventions
    Seasonale [levonorgestrel (LNG)/ethinyl estradiol (EE)]; Seasonique (LNG/EE and EE); Portia (LNG/EE)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-06
    Completion
    2006-06
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionSeasonale [levonorgestrel (LNG)/ethinyl estradiol (EE)]; Seasonique (LNG/EE and EE); Portia (LNG/EE)
    PhasePhase 3
    Registry statusCompleted