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AMR Drug RepurposingSmart Screeningresearch prototype

Alvimopan

FDA-approved product (capsule, oral), marketed as Alvimopan, Entereg.

Registered studies
26
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Alvimopan
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Constipation

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Peripheral opioid receptor antagonists
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA49.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli44.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae25.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis51.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

26registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Alvimopan in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-9.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Alvimopan with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study of Surgical Techniques During Cystectomy

    NCT06703476 · start 2024-11-21

    Registered record
    Registry ID
    NCT06703476
    Conditions
    Bladder Cancer
    Interventions
    Stent placement; Alvimopan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2024-11-21
    Completion
    2028-11
    Enrolment
    530

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBladder Cancer
    InterventionStent placement; Alvimopan
    PhasePhase 3
    Registry statusRecruiting

  • Conventional VS Enhanced Recovery After Surgery Protocols in Emergency GIT Surgery

    NCT04584060 · start 2020-12-01

    Registered record
    Registry ID
    NCT04584060
    Conditions
    Patient Presented With Acute Abdomen; Patient Undergoing Urgent GIT Surgery
    Interventions
    ERAS protocols; Early oral feeding; Prophylaxis against DVT
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2020-12-01
    Completion
    2022-02-28
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatient Presented With Acute Abdomen; Patient Undergoing Urgent GIT Surgery
    InterventionERAS protocols; Early oral feeding; Prophylaxis against DVT
    PhaseNot recorded
    Registry statusUnknown

  • Alvimopan as a Rescue Treatment of Postoperative Ileus

    NCT04405037 · start 2020-08-01

    Registered record
    Registry ID
    NCT04405037
    Conditions
    Ileus; Gastrointestinal Dysfunction
    Interventions
    Alvimopan
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-08-01
    Completion
    2024-04-02
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIleus; Gastrointestinal Dysfunction
    InterventionAlvimopan
    PhasePhase 4
    Registry statusCompleted

  • Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol

    NCT03216525 · start 2018-10-01

    Registered record
    Registry ID
    NCT03216525
    Conditions
    Bladder Cancer
    Interventions
    Alvimopan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2018-10-01
    Completion
    2024-06-01
    Enrolment
    136

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBladder Cancer
    InterventionAlvimopan; Placebo
    PhasePhase 3
    Registry statusRecruiting

  • Phase 2 RCT of Alvimopan vs. Placebo After CRS/HIPEC

    NCT03352414 · start 2018-03-08

    Registered record
    Registry ID
    NCT03352414
    Conditions
    Ileus
    Interventions
    Alvimopan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2018-03-08
    Completion
    2020-04-28
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIleus
    InterventionAlvimopan; Placebo
    PhasePhase 2
    Registry statusTerminated

  • Alvimopan Use in Polytraumatized Patients

    NCT03068975 · start 2017-09-01

    Registered record
    Registry ID
    NCT03068975
    Conditions
    Post Operative Ileus
    Interventions
    Alvimopan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-09-01
    Completion
    2019-11-19
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Operative Ileus
    InterventionAlvimopan; Placebo
    PhasePhase 4
    Registry statusTerminated

  • Ketamine in Colorectal Surgery

    NCT02785003 · start 2016-07

    Registered record
    Registry ID
    NCT02785003
    Conditions
    Acute Pain; Pain, Postoperative; Colorectal Surgery
    Interventions
    Placebo; Ketamine; Acetaminophen; Opioid; Alvimopan
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2016-07
    Completion
    2018-08
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain; Pain, Postoperative; Colorectal Surgery
    InterventionPlacebo; Ketamine; Acetaminophen; Opioid +1 more
    PhasePhase 4
    Registry statusWithdrawn

  • Trial of Alvimopan in Major Spine Surgery

    NCT02789111 · start 2016-06-01

    Registered record
    Registry ID
    NCT02789111
    Conditions
    Constipation
    Interventions
    Alvimopan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-06-01
    Completion
    2018-12-01
    Enrolment
    49

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation
    InterventionAlvimopan; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Alvimopan as Rescue in Post op Ileus

    NCT02742181 · start 2015-12-02

    Registered record
    Registry ID
    NCT02742181
    Conditions
    Colorectal Surgery; Ileus
    Interventions
    Alvimopan; Control Group
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-12-02
    Completion
    2018-07-01
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Surgery; Ileus
    InterventionAlvimopan; Control Group
    PhasePhase 3
    Registry statusTerminated

  • Gastrointestinal Tract Recovery in Patients Undergoing Open Ventral Hernia Repair

    NCT02379858 · start 2015-07

    Registered record
    Registry ID
    NCT02379858
    Conditions
    Ventral Hernia
    Interventions
    Alvimopan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2015-07
    Completion
    2018-05-31
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentral Hernia
    InterventionAlvimopan; Placebo
    PhaseNot applicable
    Registry statusTerminated

  • Alvimopan and Ileus in PSF

    NCT02218190 · start 2014-08

    Registered record
    Registry ID
    NCT02218190
    Conditions
    Ileus; Spinal Fusion
    Interventions
    Alvimopan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-08
    Completion
    2019-01
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIleus; Spinal Fusion
    InterventionAlvimopan; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Accelerating Gastrointestinal Recovery

    NCT01704651 · start 2013-01

    Registered record
    Registry ID
    NCT01704651
    Conditions
    Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer
    Interventions
    Alvimopan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-01
    Completion
    2015-10
    Enrolment
    146

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer
    InterventionAlvimopan; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Entereg Laparoscopic Colon Resection Study

    NCT01258569 · start 2010-11

    Registered record
    Registry ID
    NCT01258569
    Conditions
    Laparoscopic Colonic Resection
    Interventions
    Entereg; Entereg; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-11
    Completion
    2015-07
    Enrolment
    135

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaparoscopic Colonic Resection
    InterventionEntereg; Entereg; placebo
    PhasePhase 2
    Registry statusCompleted

  • Intermountain Healthcare's Enhanced Recovery Protocol for Colon Surgery With and Without Alvimopan Use

    NCT01143259 · start 2010-05

    Registered record
    Registry ID
    NCT01143259
    Conditions
    Ileus
    Interventions
    Alvimopam; 300 mg Polyethylene
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-05
    Completion
    2012-08
    Enrolment
    274

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIleus
    InterventionAlvimopam; 300 mg Polyethylene
    PhaseNot applicable
    Registry statusCompleted

  • Clinical Outcomes After Bowel Resection in Patients Receiving Alvimopan Versus Patients Not Receiving Alvimopan in the Premier Perspective Database

    NCT01150760 · start 2010-04

    Registered record
    Registry ID
    NCT01150760
    Conditions
    Ileus
    Interventions
    Alvimopan
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-04
    Completion
    2010-08
    Enrolment
    7,050

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIleus
    InterventionAlvimopan
    PhaseNot recorded
    Registry statusCompleted