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AMR Drug RepurposingSmart Screeningresearch prototype

Betamethasone

FDA-approved product (tablet, oral), marketed as Celestone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Betamethasone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Corticosteroids acting locally; Corticosteroids; Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA53.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli32.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae30.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis25.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Betamethasone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Betamethasone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • OPtimal TIming of COrticosteroids in Early-onset Fetal Growth REstriction: the OPTICORE Study

    NCT05606497 · start 2022-05-11

    Registered record
    Registry ID
    NCT05606497
    Conditions
    Fetal Growth Retardation
    Interventions
    Corticosteroid
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2022-05-11
    Completion
    2024-11-01
    Enrolment
    1,800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFetal Growth Retardation
    InterventionCorticosteroid
    PhaseNot recorded
    Registry statusUnknown

  • Does Steroid Plus CO2 Laser Improve Lichen Sclerosus Symptoms Compared to Steroids Alone?

    NCT05243563 · start 2022-04-13

    Registered record
    Registry ID
    NCT05243563
    Conditions
    Vulvar Lichen Sclerosus
    Interventions
    MonaLisa Touch; Topical steroid
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2022-04-13
    Completion
    2024-06-03
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVulvar Lichen Sclerosus
    InterventionMonaLisa Touch; Topical steroid
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • Comparison of Subacromial Ozone (O2-O3) and Corticosteroid Injections in the Treatment of Rotator Cuff Tendinopathy

    NCT05207384 · start 2022-01-27

    Registered record
    Registry ID
    NCT05207384
    Conditions
    Rotator Cuff Tendinopathy
    Interventions
    Ozone (O2-O3) injection; Corticosteroid injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-01-27
    Completion
    2022-05-20
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Tendinopathy
    InterventionOzone (O2-O3) injection; Corticosteroid injection
    PhaseNot applicable
    Registry statusCompleted

  • The Effect Of Antenatal Corticosteroids On Early And Late Perinatal Outcomes

    NCT06164080 · start 2021-06-01

    Registered record
    Registry ID
    NCT06164080
    Conditions
    Preterm Pregnancy; Antenatal Corticosteroid; Perinatal Problems
    Interventions
    participants receiving Corticosteroid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-06-01
    Completion
    2022-10-01
    Enrolment
    459

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Pregnancy; Antenatal Corticosteroid; Perinatal Problems
    Interventionparticipants receiving Corticosteroid
    PhaseNot applicable
    Registry statusCompleted

  • Single Versus Repeat Betamethasone in Twin Pregnancies

    NCT04212312 · start 2020-02-01

    Registered record
    Registry ID
    NCT04212312
    Conditions
    Twin; Complicating Pregnancy
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2020-02-01
    Completion
    2021-01-01
    Enrolment
    2,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTwin; Complicating Pregnancy
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Study to Evaluate the Safety and Antipsoriatic Efficacy of BOS-475 in a Psoriasis Plaque Test

    NCT04221906 · start 2020-01-06

    Registered record
    Registry ID
    NCT04221906
    Conditions
    Chronic Plaque Psoriasis
    Interventions
    BOS-475; Active ingredient-free vehicle cream; Daivonex cream (calcipotriol 0.005%); Betnesol-V cream (betamethasone 0.1%)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2020-01-06
    Completion
    2020-03-06
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Plaque Psoriasis
    InterventionBOS-475; Active ingredient-free vehicle cream; Daivonex cream (calcipotriol 0.005%); Betnesol-V cream (betamethasone 0.1%)
    PhasePhase 1
    Registry statusCompleted

  • Effectiveness of Supervised Exercise Program in Subacromial Impingement Syndrome

    NCT04186624 · start 2019-12-05

    Registered record
    Registry ID
    NCT04186624
    Conditions
    Subacromial Impingement Syndrome
    Interventions
    Subacromial-subdeltoid bursa corticosteroid injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-12-05
    Completion
    2020-08-01
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubacromial Impingement Syndrome
    InterventionSubacromial-subdeltoid bursa corticosteroid injection
    PhaseNot applicable
    Registry statusCompleted

  • Continuous Glucose Monitoring of Late Preterm Birth After Corticosteroids

    NCT03738293 · start 2019-12

    Registered record
    Registry ID
    NCT03738293
    Conditions
    Pregnancy Preterm; Neonatal Hypoglycemia; Prematurity
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Withdrawn
    Start
    2019-12
    Completion
    2020-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy Preterm; Neonatal Hypoglycemia; Prematurity
    InterventionNot recorded
    PhaseNot recorded
    Registry statusWithdrawn

  • Treatment of Tendon Disease Using Autologous Adipose-derived Mesenchymal Stem Cells

    NCT03279796 · start 2018-10-01

    Registered record
    Registry ID
    NCT03279796
    Conditions
    Rotator Cuff Tear; Lateral Epicondylitis
    Interventions
    Autologous adipose-derived MSCs; Compound betamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2018-10-01
    Completion
    2021-12-31
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Tear; Lateral Epicondylitis
    InterventionAutologous adipose-derived MSCs; Compound betamethasone
    PhasePhase 2
    Registry statusUnknown

  • India Dexamethasone and Betamethasone

    NCT03668860 · start 2018-09-20

    Registered record
    Registry ID
    NCT03668860
    Conditions
    Preterm Birth; Antenatal Corticosteroids
    Interventions
    Dexamethasone 4 mg/ml; Betamethasone 4 mg/ml; Celestone Soluspan 6Mg/Ml Suspension for Injection; Dexamethasone Oral Tablet; Betamethasone Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2018-09-20
    Completion
    2019-12-31
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Birth; Antenatal Corticosteroids
    InterventionDexamethasone 4 mg/ml; Betamethasone 4 mg/ml; Celestone Soluspan 6Mg/Ml Suspension for Injection; Dexamethasone Oral Tablet +1 more
    PhasePhase 1
    Registry statusCompleted

  • Effect of Antenatal Corticosteroids on Neonatal Morbidity.

    NCT03446937 · start 2017-12-01

    Registered record
    Registry ID
    NCT03446937
    Conditions
    Neonatal Respiratory Distress Syndrome
    Interventions
    Dexamethasone Sodium Phosphate Injection; Betamethasone Sodium Phosphate Injection (Medication); Water for injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-12-01
    Completion
    2019-05-31
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeonatal Respiratory Distress Syndrome
    InterventionDexamethasone Sodium Phosphate Injection; Betamethasone Sodium Phosphate Injection (Medication); Water for injection
    PhaseNot applicable
    Registry statusCompleted

  • To Study Generic Calcipotriene and Betamethasone Dipropionate Topical Suspension, 0.005%/0.064%, in the Treatment of Scalp Psoriasis

    NCT03331523 · start 2017-10-20

    Registered record
    Registry ID
    NCT03331523
    Conditions
    Scalp Psoriasis
    Interventions
    Calcipotriene/Betamethasone Dipropionate; Taclonex®; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-10-20
    Completion
    2018-10-25
    Enrolment
    643

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScalp Psoriasis
    InterventionCalcipotriene/Betamethasone Dipropionate; Taclonex®; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Low Vision Patients' Preference for Colored Filters and Illumination for Near Reading Determined by the LuxIQ/2

    NCT03192722 · start 2017-04-20

    Registered record
    Registry ID
    NCT03192722
    Conditions
    Ocular Conditions Resulting in Visual Impairment
    Interventions
    Colored near reading glasses; Lighting as determined by LuxIQ/2 or OttLite Cobra
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-04-20
    Completion
    2023-05-31
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOcular Conditions Resulting in Visual Impairment
    InterventionColored near reading glasses; Lighting as determined by LuxIQ/2 or OttLite Cobra
    PhaseNot applicable
    Registry statusCompleted

  • Non-surgical Treatment of Carpal Tunnel Syndrome: Night Splint Versus Local Corticosteroid Infiltration

    NCT03196817 · start 2016-08-01

    Registered record
    Registry ID
    NCT03196817
    Conditions
    Carpal Tunnel Syndrome
    Interventions
    betamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%; Wrist splinting
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-08-01
    Completion
    2017-12
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarpal Tunnel Syndrome
    Interventionbetamethasone dipropionate, betamethasone disodium phosphate and lidocaine 2%; Wrist splinting
    PhasePhase 4
    Registry statusUnknown

  • Pharmacokinetics (PK) and Modeling of Betamethasone Therapy in Threatened Preterm Birth

    NCT02793700 · start 2016-07

    Registered record
    Registry ID
    NCT02793700
    Conditions
    Premature Labor
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-07
    Completion
    2022-03
    Enrolment
    210

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPremature Labor
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted