Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Quetiapine Fumarate

FDA-approved product (tablet, oral), marketed as Quetiapine Fumarate, Seroquel, Seroquel Xr.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Quetiapine Fumarate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bipolar disorder
  • Bipolar I disorder
  • Bipolar II disorder
  • Major depressive disorder
  • Psychosis
  • Schizoaffective disorder
  • Schizophrenia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Diazepines, oxazepines, thiazepines and oxepines
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA31.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli46.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis52.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Quetiapine Fumarate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Quetiapine Fumarate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy and Safety Study of Seroquel SR in the Treatment of Major Depressive Disorder

    NCT00388973 · start 2006-09

    Registered record
    Registry ID
    NCT00388973
    Conditions
    Major Depressive Disorder
    Interventions
    Quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2007-12
    Enrolment
    338

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionQuetiapine
    PhasePhase 3
    Registry statusCompleted

  • Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in the Treatment of Major Depressive Disorders

    NCT00326144 · start 2006-04

    Registered record
    Registry ID
    NCT00326144
    Conditions
    Major Depressive Disorder
    Interventions
    Quetiapine fumarate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-04
    Completion
    2007-05
    Enrolment
    310

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionQuetiapine fumarate
    PhasePhase 3
    Registry statusCompleted

  • Quetiapine Fumarate as Monotherapy in the Maintenance Treatment of Patients With Major Depressive Disorder

    NCT00278941 · start 2005-12

    Registered record
    Registry ID
    NCT00278941
    Conditions
    Major Depressive Disorder
    Interventions
    Quetiapine Fumarate Sustained Release
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-12
    Completion
    2007-08
    Enrolment
    3,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionQuetiapine Fumarate Sustained Release
    PhasePhase 3
    Registry statusCompleted

  • Seroquel in Acute Mania: Study to Investigate if Valproate Add-On Therapy is Superior to Quetiapine Monotherapy in Acutely Manic Patients

    NCT00139074 · start 2005-07

    Registered record
    Registry ID
    NCT00139074
    Conditions
    Bipolar Disorder
    Interventions
    Quetiapine fumarate; sodium valproate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2005-07
    Completion
    2006-06
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionQuetiapine fumarate; sodium valproate
    PhasePhase 4
    Registry statusTerminated

  • Rapid Dose Escalation of Quetiapine Versus Conventional Escalation in Acute Schizophrenic Patients

    NCT00254787 · start 2005-06

    Registered record
    Registry ID
    NCT00254787
    Conditions
    Schizophrenia
    Interventions
    IR (Immediate-Release) quetiapine fumarate (drug)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-06
    Completion
    2006-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionIR (Immediate-Release) quetiapine fumarate (drug)
    PhasePhase 2
    Registry statusCompleted

  • Seroquel in Bipolar Depression Versus SSRI

    NCT00119652 · start 2005-05

    Registered record
    Registry ID
    NCT00119652
    Conditions
    Bipolar Disorder; Bipolar Depression; Depression
    Interventions
    quetiapine fumarate (Seroquel); paroxetine; mood stabilizing activity
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-05
    Completion
    2007-05
    Enrolment
    676

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder; Bipolar Depression; Depression
    Interventionquetiapine fumarate (Seroquel); paroxetine; mood stabilizing activity
    PhasePhase 3
    Registry statusCompleted

  • Treatment of Mania Symptoms With Drug Therapy

    NCT00183443 · start 2005-02

    Registered record
    Registry ID
    NCT00183443
    Conditions
    Bipolar Disorder; Schizophrenia
    Interventions
    Divalproex-extended release (DVP-ER); Lithium; Quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-02
    Completion
    2010-11
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder; Schizophrenia
    InterventionDivalproex-extended release (DVP-ER); Lithium; Quetiapine
    PhasePhase 3
    Registry statusCompleted

  • Study Measuring Differences in Cognition Due to Sedative Effects of Risperidone and Quetiapine in Stable Bipolar I Outpatients

    NCT00097032 · start 2004-10

    Registered record
    Registry ID
    NCT00097032
    Conditions
    Bipolar Disorder
    Interventions
    risperidone; quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-10
    Completion
    2005-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    Interventionrisperidone; quetiapine
    PhasePhase 3
    Registry statusCompleted

  • Fast Titration Of Quetiapine Versus Currently Approved Titration

    NCT00254813 · start 2004-10

    Registered record
    Registry ID
    NCT00254813
    Conditions
    Psychotic Disorders
    Interventions
    Quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-10
    Completion
    2005-09
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsychotic Disorders
    InterventionQuetiapine
    PhasePhase 3
    Registry statusCompleted

  • Comparison of Continuing Olanzapine to Switching to Quetiapine in Overweight or Obese Patients With Schizophrenia and Schizoaffective Disorder

    NCT00090012 · start 2004-07

    Registered record
    Registry ID
    NCT00090012
    Conditions
    Schizophrenia; Schizoaffective Disorder
    Interventions
    Olanzapine; Quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-07
    Completion
    2006-03
    Enrolment
    340

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder
    InterventionOlanzapine; Quetiapine
    PhasePhase 4
    Registry statusCompleted

  • Combination of Paroxetine CR and Quetiapine for the Treatment of Refractory Generalized Anxiety Disorder

    NCT00113295 · start 2004-02

    Registered record
    Registry ID
    NCT00113295
    Conditions
    Anxiety Disorder
    Interventions
    Continued Paroxetine CR; Quetiapine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-02
    Completion
    2007-11
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety Disorder
    InterventionContinued Paroxetine CR; Quetiapine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Addition of Quetiapine in Obsessive Compulsive Disorder - Westenberg Study

    NCT00318539 · start 2003-12

    Registered record
    Registry ID
    NCT00318539
    Conditions
    Obsessive Compulsive Disorder
    Interventions
    Quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-12
    Completion
    2006-08
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive Compulsive Disorder
    InterventionQuetiapine
    PhasePhase 2
    Registry statusCompleted

  • Risperdal Consta for Bipolar Disorder

    NCT00177164 · start 2003-11

    Registered record
    Registry ID
    NCT00177164
    Conditions
    Bipolar I Disorder
    Interventions
    Injectable Risperidone (Consta) or oral antipsychotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-11
    Completion
    2009-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar I Disorder
    InterventionInjectable Risperidone (Consta) or oral antipsychotic
    PhasePhase 3
    Registry statusCompleted

  • Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia

    NCT00208143 · start 2003-11

    Registered record
    Registry ID
    NCT00208143
    Conditions
    Schizophrenia; Schizoaffective Disorder; Substance Abuse; Substance Dependence
    Interventions
    Quetiapine; Risperidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-11
    Completion
    2005-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder; Substance Abuse; Substance Dependence
    InterventionQuetiapine; Risperidone
    PhasePhase 4
    Registry statusCompleted

  • A Study of the Cataractogenic Potential of Seroquel and Risperdal in the Treatment of Participants With Schizophrenia or Schizoaffective Disorder

    NCT00206102 · start 2003-09

    Registered record
    Registry ID
    NCT00206102
    Conditions
    Schizophrenia; Schizoaffective Disorder
    Interventions
    quetiapine fumarate; risperidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-09
    Completion
    2008-10
    Enrolment
    1,098

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder
    Interventionquetiapine fumarate; risperidone
    PhasePhase 4
    Registry statusCompleted