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AMR Drug RepurposingSmart Screeningresearch prototype

Quetiapine Fumarate

FDA-approved product (tablet, oral), marketed as Quetiapine Fumarate, Seroquel, Seroquel Xr.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Quetiapine Fumarate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bipolar disorder
  • Bipolar I disorder
  • Bipolar II disorder
  • Major depressive disorder
  • Psychosis
  • Schizoaffective disorder
  • Schizophrenia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Diazepines, oxazepines, thiazepines and oxepines
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA31.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli46.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis52.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Quetiapine Fumarate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Quetiapine Fumarate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms

    NCT00955474 · start 2008-09

    Registered record
    Registry ID
    NCT00955474
    Conditions
    Major Depressive Disorder With Psychotic Features
    Interventions
    Quetiapine; escitalopram; Sertraline; Citalopram
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2008-09
    Completion
    2013-01
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder With Psychotic Features
    InterventionQuetiapine; escitalopram; Sertraline; Citalopram
    PhasePhase 4
    Registry statusTerminated

  • Open-Label Pilot Study to Examine the Value of Substituting Quetiapine for Benzodiazepines

    NCT01244711 · start 2008-09

    Registered record
    Registry ID
    NCT01244711
    Conditions
    Major Depression; Generalized Anxiety Disorder
    Interventions
    quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2008-09
    Completion
    2011-09
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depression; Generalized Anxiety Disorder
    Interventionquetiapine
    PhasePhase 4
    Registry statusTerminated

  • Quetiapine in the Treatment of Postpartum Depression (PPD) in Bipolar Disorder (BD), Type II

    NCT01527448 · start 2008-04

    Registered record
    Registry ID
    NCT01527448
    Conditions
    Postpartum Depression
    Interventions
    Quetiapine XR (seroquel)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-04
    Completion
    2010-07
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostpartum Depression
    InterventionQuetiapine XR (seroquel)
    PhaseNot applicable
    Registry statusCompleted

  • Quetiapine Induced Neuroplasticity in First-episode Schizophrenic Patients

    NCT00554658 · start 2008-03

    Registered record
    Registry ID
    NCT00554658
    Conditions
    Schizophrenia
    Interventions
    Quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-03
    Completion
    2011-03
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionQuetiapine
    PhasePhase 4
    Registry statusCompleted

  • Study Evaluating the Clinical Benefit of SEROQUEL XR in Subjects With Schizophrenia

    NCT00640601 · start 2008-03

    Registered record
    Registry ID
    NCT00640601
    Conditions
    Schizophrenia
    Interventions
    Quetiapine Fumarate Extended- Release
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2010-07
    Enrolment
    331

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionQuetiapine Fumarate Extended- Release
    PhasePhase 3
    Registry statusCompleted

  • Open Label Seroquel (Quetiapine) Study for Treatment Resistant Functional Bowel Disorder

    NCT00617396 · start 2008-02

    Registered record
    Registry ID
    NCT00617396
    Conditions
    Functional Bowel Disorders
    Interventions
    Quetiapine (50 mg/day-100mg/day)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-02
    Completion
    2012-05
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFunctional Bowel Disorders
    InterventionQuetiapine (50 mg/day-100mg/day)
    PhaseNot applicable
    Registry statusCompleted

  • Study of the Effectiveness of Quetiapine for the Treatment of Alcohol Dependency

    NCT00498628 · start 2007-12

    Registered record
    Registry ID
    NCT00498628
    Conditions
    Alcoholism; Alcohol Abuse
    Interventions
    Quetiapine fumarate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-12
    Completion
    2010-03
    Enrolment
    224

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholism; Alcohol Abuse
    InterventionQuetiapine fumarate; Placebo
    PhasePhase 2
    Registry statusCompleted

  • A Phase 4 Study to Assess the Effects of Aripiprazole Versus Other Atypical Antipsychotics in the Treatment of Schizophrenic Patients With Metabolic Syndrome

    NCT00508157 · start 2007-11

    Registered record
    Registry ID
    NCT00508157
    Conditions
    Metabolic Syndrome; Schizophrenia
    Interventions
    Aripiprazole; Continued Antipsychotic (Risperidone or Quetiapine or Olanzapine)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2007-11
    Completion
    2009-03
    Enrolment
    125

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolic Syndrome; Schizophrenia
    InterventionAripiprazole; Continued Antipsychotic (Risperidone or Quetiapine or Olanzapine)
    PhasePhase 4
    Registry statusTerminated

  • Quality of Life (QOL) in Female Patient With Schizophrenia

    NCT00498004 · start 2007-08

    Registered record
    Registry ID
    NCT00498004
    Conditions
    Schizophrenia
    Interventions
    Quetiapine, Risperidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2007-08
    Completion
    2008-09
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionQuetiapine, Risperidone
    PhasePhase 4
    Registry statusTerminated

  • Using Drug Augmentation to Treat Obsessive Compulsive Disorder Patients Who Did Not Respond to Previous Treatment

    NCT00466609 · start 2007-05

    Registered record
    Registry ID
    NCT00466609
    Conditions
    Obsessive Compulsive Disorder
    Interventions
    Clomipramine (fluoxetine plus clomipramine); Quetiapine (fluoxetine plus quetiapine); Placebo (fluoxetine plus placebo)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-05
    Completion
    2010-04
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive Compulsive Disorder
    InterventionClomipramine (fluoxetine plus clomipramine); Quetiapine (fluoxetine plus quetiapine); Placebo (fluoxetine plus placebo)
    PhasePhase 4
    Registry statusCompleted

  • Group Cognitive Behavioral Therapy (CBT I) Vs. Quetiapine for Residual Insomnia Impairing Recovery Among Elderly With Stable Major Affective Disorders

    NCT00462618 · start 2007-04

    Registered record
    Registry ID
    NCT00462618
    Conditions
    Insomnia
    Interventions
    Quetiapine; Cogntive behavioral therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2007-04
    Completion
    2008-03
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia
    InterventionQuetiapine; Cogntive behavioral therapy
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome

    NCT00675896 · start 2007-04

    Registered record
    Registry ID
    NCT00675896
    Conditions
    Major Depression
    Interventions
    Quetiapine Fumarate Sustained Release; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-04
    Completion
    2011-07
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depression
    InterventionQuetiapine Fumarate Sustained Release; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Phase 3 /Seroquel SR Acute Mania Monotherapy - US

    NCT00422123 · start 2007-01

    Registered record
    Registry ID
    NCT00422123
    Conditions
    Affective Psychosis, Bipolar; Manic Disorder; Manic-Depressive Psychosis; Mania; Manic State; Psychoses, Manic-Depressive
    Interventions
    Quetiapine fumarate (Seroquel) SR
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-01
    Completion
    2007-07
    Enrolment
    447

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAffective Psychosis, Bipolar; Manic Disorder; Manic-Depressive Psychosis; Mania +2 more
    InterventionQuetiapine fumarate (Seroquel) SR
    PhasePhase 3
    Registry statusCompleted

  • The Use of Quetiapine (Seroquel) in the Treatment of Social Phobia: Public Speaking Environment

    NCT00407199 · start 2006-12

    Registered record
    Registry ID
    NCT00407199
    Conditions
    Social Phobia
    Interventions
    quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-12
    Completion
    2007-09
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSocial Phobia
    Interventionquetiapine
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients

    NCT00375557 · start 2006-10

    Registered record
    Registry ID
    NCT00375557
    Conditions
    Alzheimer's Disease; Dementia; Behavioral Symptoms
    Interventions
    Divalproex ER; Quetiapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2006-10
    Completion
    2007-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease; Dementia; Behavioral Symptoms
    InterventionDivalproex ER; Quetiapine
    PhasePhase 4
    Registry statusWithdrawn