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AMR Drug RepurposingSmart Screeningresearch prototype

Oxacillin Sodium

FDA-approved product (capsule, oral), marketed as Bactocill, Bactocill In Plastic Container, Oxacillin Sodium and 1 more.

Registered studies
50+
Lab records
22
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Oxacillin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta-lactamase resistant penicillins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CF04

Repurposing investigation

Oxacillin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA9.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli32.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae46.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis39.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 9 of 22 lab records
Open Oxacillin Sodium in ChEMBL Registered studies below
Show the 22 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Oxacillin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Staphylococcus Aureus Bacteremia Antibiotic Treatment Options

    NCT01792804 · start 2013-12

    Registered record
    Registry ID
    NCT01792804
    Conditions
    Staphylococcus Aureus Infection
    Interventions
    Trimethoprim-Sulfamethoxazole; Clindamycin; Linezolid; Flucloxacillin; Cloxacillin; Vancomycin; Daptomycin; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-12
    Completion
    2020-03-26
    Enrolment
    215

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Infection
    InterventionTrimethoprim-Sulfamethoxazole; Clindamycin; Linezolid; Flucloxacillin +4 more
    PhasePhase 3
    Registry statusCompleted

  • Adjunctive Clindamycin for Cellulitis: C4C Trial.

    NCT01876628 · start 2013-10

    Registered record
    Registry ID
    NCT01876628
    Conditions
    Cellulitis
    Interventions
    Flucloxacillin; Clindamycin; Placebo oral capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-10
    Completion
    2016-03
    Enrolment
    410

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCellulitis
    InterventionFlucloxacillin; Clindamycin; Placebo oral capsule
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of a Short-term Sequential Therapy in Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus.

    NCT01875263 · start 2013-05

    Registered record
    Registry ID
    NCT01875263
    Conditions
    Staphylococcus
    Interventions
    Cloxacilin; Cloxacillin; Levofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2013-05
    Completion
    2014-11
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus
    InterventionCloxacilin; Cloxacillin; Levofloxacin
    PhasePhase 3
    Registry statusTerminated

  • Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infection

    NCT01191840 · start 2011-02

    Registered record
    Registry ID
    NCT01191840
    Conditions
    Bacteremia
    Interventions
    Vancomycin; Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-02
    Completion
    2017-03-04
    Enrolment
    509

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia
    InterventionVancomycin; Vancomycin
    PhasePhase 2
    Registry statusCompleted

  • Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment

    NCT01104662 · start 2010-04-19

    Registered record
    Registry ID
    NCT01104662
    Conditions
    Complicated Skin and Skin Structure Infections; S. Aureus Bacteremia; Renal Impairment
    Interventions
    Vancomycin; Daptomycin; Semi-Synthetic Penicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2010-04-19
    Completion
    2012-06-12
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplicated Skin and Skin Structure Infections; S. Aureus Bacteremia; Renal Impairment
    InterventionVancomycin; Daptomycin; Semi-Synthetic Penicillin
    PhasePhase 4
    Registry statusTerminated

  • Study to Compare Efficacy and Safety of Daptomycin in Elderly Patients With Complicated Skin and Soft Tissue Infections

    NCT01184872 · start 2010-03

    Registered record
    Registry ID
    NCT01184872
    Conditions
    Infections
    Interventions
    Daptomycin; Vancomycin or Semi-Synthetic Penicillins (SSPs)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-03
    Completion
    2011-03
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections
    InterventionDaptomycin; Vancomycin or Semi-Synthetic Penicillins (SSPs)
    PhasePhase 3
    Registry statusCompleted

  • Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infections

    NCT00711802 · start 2008-07-23

    Registered record
    Registry ID
    NCT00711802
    Conditions
    Skin Diseases, Infectious
    Interventions
    Daptomycin; Standard of Care (SOC)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-07-23
    Completion
    2013-10-11
    Enrolment
    396

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Diseases, Infectious
    InterventionDaptomycin; Standard of Care (SOC)
    PhasePhase 4
    Registry statusCompleted

  • Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis

    NCT00716183 · start 2008-07

    Registered record
    Registry ID
    NCT00716183
    Conditions
    Mastitis
    Interventions
    Lactobacillus salivarius HN6; Lactobacillus reuteri CR20; Lactobacillus fermentum LC40; Beta-lactam antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2009-05
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMastitis
    InterventionLactobacillus salivarius HN6; Lactobacillus reuteri CR20; Lactobacillus fermentum LC40; Beta-lactam antibiotic
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Cloxacillin as Prevention of Double Lumen Infection in Hemodialysis Patients

    NCT00885300 · start 2008-01

    Registered record
    Registry ID
    NCT00885300
    Conditions
    Double Lumen Infection; Hemodialysis
    Interventions
    cloxacillin; heparin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-01
    Completion
    2008-09
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDouble Lumen Infection; Hemodialysis
    Interventioncloxacillin; heparin
    PhaseNot applicable
    Registry statusCompleted

  • Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

    NCT00428844 · start 2007-06-26

    Registered record
    Registry ID
    NCT00428844
    Conditions
    Osteomyelitis
    Interventions
    daptomycin; daptomycin; vancomycin; teicoplanin; nafcillin; oxacillin; flucloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-06-26
    Completion
    2010-06-23
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventiondaptomycin; daptomycin; vancomycin; teicoplanin +3 more
    PhasePhase 2
    Registry statusCompleted

  • Staphylococcus Aureus Carriers Students Nursing Oxacillin Resistant

    NCT00518076 · start 2006-09

    Registered record
    Registry ID
    NCT00518076
    Conditions
    Staphylococcal Infections
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2006-09
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcal Infections
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Comparison Between Amoxycillin/Clavulanic Acid and Oxacillin/Ceftriaxone for Community Acquired-pneumonia

    NCT01166932 · start 2005-04

    Registered record
    Registry ID
    NCT01166932
    Conditions
    Community-Acquired Pneumonia
    Interventions
    Amoxycillin/clavulanic acid; ceftriaxone/oxacillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-04
    Completion
    2009-04
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-Acquired Pneumonia
    InterventionAmoxycillin/clavulanic acid; ceftriaxone/oxacillin
    PhasePhase 4
    Registry statusCompleted

  • Bioavailability Of Flucloxacillin Capsules (250 mg and 500 mg)

    NCT00358371 · start 2005-01-06

    Registered record
    Registry ID
    NCT00358371
    Conditions
    Infections, Bacterial
    Interventions
    flucloxacillin 250 mg; flucloxacillin 500 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2005-01-06
    Completion
    2005-02-08
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections, Bacterial
    Interventionflucloxacillin 250 mg; flucloxacillin 500 mg
    PhasePhase 1
    Registry statusCompleted

  • Phase 2 Trial of TD-6424 (Telavancin) Versus Standard Therapy for Complicated Gram Positive Skin and Skin Structure Infections (Gram Positive cSSSI)

    NCT00077675 · start 2004-02

    Registered record
    Registry ID
    NCT00077675
    Conditions
    Infections, Gram-positive Bacterial
    Interventions
    Telavancin; vancomycin or antistaphylococcal penicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-02
    Completion
    2004-09
    Enrolment
    201

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections, Gram-positive Bacterial
    InterventionTelavancin; vancomycin or antistaphylococcal penicillin
    PhasePhase 2
    Registry statusCompleted

  • Determinants of Warfarin Metabolism

    NCT00162474 · start 2003-09

    Registered record
    Registry ID
    NCT00162474
    Conditions
    Healthy
    Interventions
    Warfarin; Phenytoin; Losartan & Hydrochlorothiazide; Flurbiprofen; Siponimod; Dicloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2003-09
    Completion
    2030-12
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionWarfarin; Phenytoin; Losartan & Hydrochlorothiazide; Flurbiprofen +2 more
    PhaseNot applicable
    Registry statusRecruiting