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AMR Drug RepurposingSmart Screeningresearch prototype

Ceftriaxone Sodium

FDA-approved product (injectable, injection), marketed as Ceftriaxone, Ceftriaxone And Dextrose In Duplex Container, Ceftriaxone In Plastic Container and 3 more.

Registered studies
50+
Lab records
68
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Ceftriaxone Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Gonorrhea
  • Infection
  • Infectious meningitis
  • Otitis media
  • Pelvic Inflammatory Disease
  • Respiratory tract infectious disorder
  • Sepsis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Third-generation cephalosporins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DD04; WHO ATC J01DD54

Repurposing investigation

Ceftriaxone Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA82.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli>99% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae35.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis56.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 8 of 8 lab records
  • E. coli: measured active in 4 of 4 lab records
  • K. pneumoniae: measured active in 26 of 56 lab records
Open Ceftriaxone Sodium in ChEMBL Registered studies below
Show the 68 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ceftriaxone Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Impact of the Choice of 3rd Generation Cephalosporins on the Emergence of Resistance in the Microbiota Intestinal.

    NCT02659033 · start 2016-03

    Registered record
    Registry ID
    NCT02659033
    Conditions
    Emergence of Bacterial Resistance to Antibiotics
    Interventions
    ceftriaxone; Cefotaxime
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-03
    Completion
    2017-12
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEmergence of Bacterial Resistance to Antibiotics
    Interventionceftriaxone; Cefotaxime
    PhasePhase 3
    Registry statusCompleted

  • PROPHY-VAP: Prevention of Early Ventilation Acquired Pneumonia (VAP) in Brain Injured Patients by a Single Dose of Ceftriaxone

    NCT02265406 · start 2015-10

    Registered record
    Registry ID
    NCT02265406
    Conditions
    Early Ventilation Acquired Pneumonia in Brain Injured Patients
    Interventions
    Anti-Infective Agents; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-10
    Completion
    2020-07-25
    Enrolment
    354

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEarly Ventilation Acquired Pneumonia in Brain Injured Patients
    InterventionAnti-Infective Agents; Placebo
    PhasePhase 3
    Registry statusCompleted

  • PHase IV Clinical Trial of Ceftriaxone Sodium and Sulbactam Sodium for Injection (CRO-SBT)

    NCT04066621 · start 2015-04-28

    Registered record
    Registry ID
    NCT04066621
    Conditions
    Respiratory Tract Infections; Urinary Tract Infections in Children
    Interventions
    Ceftriaxone Sodium and Sulbactam Sodium for Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-04-28
    Completion
    2017-05-27
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Tract Infections; Urinary Tract Infections in Children
    InterventionCeftriaxone Sodium and Sulbactam Sodium for Injection
    PhasePhase 4
    Registry statusCompleted

  • Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial)

    NCT04870138 · start 2013-03-10

    Registered record
    Registry ID
    NCT04870138
    Conditions
    Gonococcal Infection
    Interventions
    Azithromycin; Ceftriaxone; Ciprofloxacin; Neisseria gonorrhoeae strain FA1090 A26; Neisseria gonorrhoeae strain FA7527
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-03-10
    Completion
    2015-04-28
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGonococcal Infection
    InterventionAzithromycin; Ceftriaxone; Ciprofloxacin; Neisseria gonorrhoeae strain FA1090 A26 +1 more
    PhasePhase 1
    Registry statusCompleted

  • Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection

    NCT01756924 · start 2012-12

    Registered record
    Registry ID
    NCT01756924
    Conditions
    Prosthetic Joint Infections of Hip; Prosthetic Joint Infections of Knee; Infected Spacers
    Interventions
    CEM-102; IV or Oral standard of care antibiotics; Rifampin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2012-12
    Completion
    2014-07
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProsthetic Joint Infections of Hip; Prosthetic Joint Infections of Knee; Infected Spacers
    InterventionCEM-102; IV or Oral standard of care antibiotics; Rifampin
    PhasePhase 2
    Registry statusTerminated

  • Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Complicated Community Acquired Pneumonia (CABP)

    NCT01669980 · start 2012-10

    Registered record
    Registry ID
    NCT01669980
    Conditions
    Infections; Pneumonia
    Interventions
    Ceftaroline fosamil; IV Ceftriaxone and Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-10
    Completion
    2014-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections; Pneumonia
    InterventionCeftaroline fosamil; IV Ceftriaxone and Vancomycin
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Community Acquired Bacterial Pneumonia (CABP)

    NCT01530763 · start 2012-09

    Registered record
    Registry ID
    NCT01530763
    Conditions
    Infections; Community Acquired Pneumonia
    Interventions
    Ceftaroline fosamil; Ceftriaxone; amoxicillin clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2012-09
    Completion
    2014-07
    Enrolment
    161

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections; Community Acquired Pneumonia
    InterventionCeftaroline fosamil; Ceftriaxone; amoxicillin clavulanate
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women

    NCT01390623 · start 2011-07

    Registered record
    Registry ID
    NCT01390623
    Conditions
    Acute Uncomplicated Pyelonephritis
    Interventions
    Ceftriaxone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-07
    Completion
    2013-12
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Uncomplicated Pyelonephritis
    InterventionCeftriaxone
    PhasePhase 4
    Registry statusCompleted

  • Community-Acquired Pneumonia - Study on the Initial Treatment With Antibiotics of Lower Respiratory Tract Infections

    NCT01660204 · start 2011-02

    Registered record
    Registry ID
    NCT01660204
    Conditions
    Community-acquired Pneumonia
    Interventions
    Preferred empirical treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-02
    Completion
    2014-01
    Enrolment
    2,283

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-acquired Pneumonia
    InterventionPreferred empirical treatment
    PhaseNot applicable
    Registry statusCompleted

  • Chlamydia Trachomatis Immunology and Vaccinology Study

    NCT01150747 · start 2011-01

    Registered record
    Registry ID
    NCT01150747
    Conditions
    Chlamydia
    Interventions
    ceftriaxone; Azithromycin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-01
    Completion
    2015-08
    Enrolment
    347

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChlamydia
    Interventionceftriaxone; Azithromycin
    PhaseNot recorded
    Registry statusCompleted

  • Efficacy and Safety of Ertapenem Sodium (MK-0826) Following Colorectal Surgery in Chinese Adults (MK-0826-056)

    NCT01254344 · start 2010-12

    Registered record
    Registry ID
    NCT01254344
    Conditions
    Infection; Surgical Site Infection
    Interventions
    ertapenem sodium; ceftriaxone sodium; placebo to metronidazole; metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-12
    Completion
    2011-12
    Enrolment
    599

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection; Surgical Site Infection
    Interventionertapenem sodium; ceftriaxone sodium; placebo to metronidazole; metronidazole
    PhasePhase 3
    Registry statusCompleted

  • Moxifloxacin Versus Ceftriaxone in the Treatment of Primary Pyogenic Liver Abscess

    NCT00895089 · start 2009-05

    Registered record
    Registry ID
    NCT00895089
    Conditions
    Liver Abscess
    Interventions
    Moxifloxacin (Avelox); ceftriaxone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-05
    Completion
    2011-12
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Abscess
    InterventionMoxifloxacin (Avelox); ceftriaxone
    PhasePhase 4
    Registry statusCompleted

  • A Study Of Intravenous Sulopenem And Oral PF-03709270 In Community Acquired Pneumonia That Requires Hospitalization

    NCT00797108 · start 2009-01

    Registered record
    Registry ID
    NCT00797108
    Conditions
    Pneumonia, Bacterial
    Interventions
    sulopenem and PF-03709270; Sulopenem and PF-03709270; Ceftriaxone and amoxicillin/clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-01
    Completion
    2009-06
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Bacterial
    Interventionsulopenem and PF-03709270; Sulopenem and PF-03709270; Ceftriaxone and amoxicillin/clavulanate
    PhasePhase 2
    Registry statusCompleted

  • Comparative Study of Ceftaroline vs. Ceftriaxone in Adult Subjects With Community-Acquired Pneumonia

    NCT00621504 · start 2008-01

    Registered record
    Registry ID
    NCT00621504
    Conditions
    Bacterial Pneumonia
    Interventions
    Ceftaroline fosamil for Injection; IV Ceftriaxone; Placebo; Clarithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-01
    Completion
    2009-06
    Enrolment
    606

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Pneumonia
    InterventionCeftaroline fosamil for Injection; IV Ceftriaxone; Placebo; Clarithromycin
    PhasePhase 3
    Registry statusCompleted

  • Ceftobiprole in the Treatment of Patients With Community-Acquired Pneumonia

    NCT00326287 · start 2006-06

    Registered record
    Registry ID
    NCT00326287
    Conditions
    Pneumonia
    Interventions
    Ceftobiprole medocaril; Ceftriaxone with or without Linezolid
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-06
    Completion
    2007-07
    Enrolment
    638

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    InterventionCeftobiprole medocaril; Ceftriaxone with or without Linezolid
    PhasePhase 3
    Registry statusCompleted