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AMR Drug RepurposingSmart Screeningresearch prototype

Ingenol Mebutate

FDA-approved product (gel, topical), marketed as Ingenol Mebutate, Picato.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Ingenol Mebutate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Actinic keratosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other chemotherapeutics
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC D06BX02

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA57.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli32.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis37.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ingenol Mebutate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ingenol Mebutate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • PEP005 Gel - Evaluation of Local Tolerability After Exposure to Ingenol Mebutate Gel Followed by Hand Washing in Healthy Subjects

    NCT01302925 · start 2011-02

    Registered record
    Registry ID
    NCT01302925
    Conditions
    Healthy; Actinic Keratosis
    Interventions
    PEP005 Gel; PEP005 Gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-02
    Completion
    2011-03
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy; Actinic Keratosis
    InterventionPEP005 Gel; PEP005 Gel
    PhasePhase 1
    Registry statusCompleted

  • Study to Evaluate the Safety and Efficacy of PEP005 (Ingenol Mebutate) Gel, 0.015%, in Patients With Photo-damaged Skin

    NCT01214577 · start 2010-10

    Registered record
    Registry ID
    NCT01214577
    Conditions
    Photo-damage
    Interventions
    PEP005 (ingenol mebutate) Gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-10
    Completion
    2011-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPhoto-damage
    InterventionPEP005 (ingenol mebutate) Gel
    PhasePhase 2
    Registry statusCompleted

  • A Long Term Follow up Study of Patients Who Have Complete Clearance of Their Actinic Keratosis (AK) Lesions at the Day 57 Visit in the PEP005-028 Study

    NCT00989313 · start 2009-09

    Registered record
    Registry ID
    NCT00989313
    Conditions
    Actinic Keratosis
    Interventions
    Lesion count
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-09
    Completion
    2010-10
    Enrolment
    43

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionLesion count
    PhaseNot recorded
    Registry statusCompleted

  • A Long Term Follow up Study of Patients Who Have Completed the PEP005-016 or PEP005-025 Studies

    NCT00953732 · start 2009-08

    Registered record
    Registry ID
    NCT00953732
    Conditions
    Actinic Keratosis
    Interventions
    Lesion count
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-08
    Completion
    2010-10
    Enrolment
    117

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionLesion count
    PhaseNot recorded
    Registry statusCompleted

  • A Multi-center Study to Evaluate the Safety and Efficacy of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on Non-head Locations (Trunk and Extremities)

    NCT00917306 · start 2009-06

    Registered record
    Registry ID
    NCT00917306
    Conditions
    Actinic Keratosis
    Interventions
    PEP005 Gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-06
    Completion
    2009-09
    Enrolment
    102

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionPEP005 Gel
    PhasePhase 3
    Registry statusCompleted

  • A Study to Evaluate the Pharmacokinetics of PEP005 (Ingenol Mebutate) Gel, 0.05%, When Applied in a Maximal Use Setting to the Dorsal Aspect of the Forearm in Patients With Actinic Keratosis

    NCT00852137 · start 2009-03

    Registered record
    Registry ID
    NCT00852137
    Conditions
    Actinic Keratosis
    Interventions
    PEP005 (ingenol mebutate) Gel, 0.05%; Vehicle Gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-03
    Completion
    2009-06
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionPEP005 (ingenol mebutate) Gel, 0.05%; Vehicle Gel
    PhasePhase 2
    Registry statusCompleted

  • A Study to Evaluate the Photoallergic Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteers

    NCT00850681 · start 2009-02

    Registered record
    Registry ID
    NCT00850681
    Conditions
    Actinic Keratosis
    Interventions
    PEP005 (ingenol mebutate) Gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-02
    Completion
    2009-04
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionPEP005 (ingenol mebutate) Gel
    PhasePhase 1
    Registry statusCompleted

  • A Study to Evaluate the Photoirritation Potential of PEP005 (Ingenol Mebutate) Gel, 0.01% in Healthy Volunteers

    NCT00850811 · start 2009-02

    Registered record
    Registry ID
    NCT00850811
    Conditions
    Actinic Keratosis
    Interventions
    PEP005 (ingenol mebutate) Gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-02
    Completion
    2009-04
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionPEP005 (ingenol mebutate) Gel
    PhasePhase 1
    Registry statusCompleted

  • A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations

    NCT00742391 · start 2008-09

    Registered record
    Registry ID
    NCT00742391
    Conditions
    Actinic Keratoses
    Interventions
    PEP005 (ingenol mebutate) Gel; Vehicle gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-09
    Completion
    2009-02
    Enrolment
    255

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratoses
    InterventionPEP005 (ingenol mebutate) Gel; Vehicle gel
    PhasePhase 3
    Registry statusCompleted

  • A Multicenter Study to Evaluate the Safety and Efficacy of PEP005 Topical Gel When Used to Treat Actinic Keratoses on the Head (Face or Scalp)

    NCT00700063 · start 2008-06

    Registered record
    Registry ID
    NCT00700063
    Conditions
    Actinic Keratosis
    Interventions
    PEP005 Topical Gel; PEP005 Topical Gel; PEP005 Topical Gel; Vehicle gel; PEP005 Topical Gel; PEP005 Topical Gel; PEP005 Topical Gel; Vehicle gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-06
    Completion
    2008-10
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionPEP005 Topical Gel; PEP005 Topical Gel; PEP005 Topical Gel; Vehicle gel +4 more
    PhasePhase 2
    Registry statusCompleted

  • A Study to Examine the Safety and Toleration of PEP005 Topical Gel in Patients With Actinic Keratoses on the Top of the Hand

    NCT00544297 · start 2007-10

    Registered record
    Registry ID
    NCT00544297
    Conditions
    Actinic Keratosis
    Interventions
    PEP005 gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-10
    Completion
    2008-01
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratosis
    InterventionPEP005 gel
    PhasePhase 2
    Registry statusCompleted

  • The Purpose of This Study is to Determine Whether Topical Application of PEP005 is Safe for the Treatment of Common Wart(s)

    NCT00546611 · start 2007-10

    Registered record
    Registry ID
    NCT00546611
    Conditions
    Warts
    Interventions
    PEP005
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2007-10
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWarts
    InterventionPEP005
    PhasePhase 1
    Registry statusWithdrawn

  • To Determine the Maximum Tolerated Dose Level (MTD) of PEP005 Topical Gel in Patients With sBCC

    NCT00432185 · start 2007-02

    Registered record
    Registry ID
    NCT00432185
    Conditions
    Superficial Basal Cell Carcinoma
    Interventions
    PEP005
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-02
    Completion
    2010-03
    Enrolment
    117

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSuperficial Basal Cell Carcinoma
    InterventionPEP005
    PhasePhase 2
    Registry statusCompleted

  • A Study to Determine the Optimal Tolerated Regime and Safety of PEP005 Topical Gel

    NCT00427050 · start 2007-01

    Registered record
    Registry ID
    NCT00427050
    Conditions
    Actinic Keratoses
    Interventions
    PEP005
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-01
    Completion
    2007-11
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionActinic Keratoses
    InterventionPEP005
    PhasePhase 2
    Registry statusCompleted

  • Study to Determine the Sensitizing Potential of PEP005 Topical Gel in Healthy Volunteers Using a Repeat Insult Patch Test Design

    NCT00357916 · start 2006-06

    Registered record
    Registry ID
    NCT00357916
    Conditions
    Healthy
    Interventions
    PEP005 Topical Gel (0.01% concentration)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-06
    Completion
    2006-10
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionPEP005 Topical Gel (0.01% concentration)
    PhasePhase 1
    Registry statusCompleted