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AMR Drug RepurposingSmart Screeningresearch prototype

Mifepristone

FDA-approved product (tablet, oral), marketed as Korlym, Mifeprex, Mifepristone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Mifepristone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cushing syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Progesterone receptor modulators
FDA pharmacologic class
Progestin Antagonist FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA55.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli42.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae39.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Mifepristone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

-4.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Mifepristone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Mifepristone and Mid-Trimester Termination of Pregnancy

    NCT00382538 · start 2005-03

    Registered record
    Registry ID
    NCT00382538
    Conditions
    Abortion, Induced; Abortion, Second Trimester
    Interventions
    Addition of mifepristone 200 mg 24 hours before induction
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-03
    Completion
    2006-11
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion, Induced; Abortion, Second Trimester
    InterventionAddition of mifepristone 200 mg 24 hours before induction
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Mifepristone on Uterine Fibroids and Breast Tissue

    NCT00579475 · start 2004-11

    Registered record
    Registry ID
    NCT00579475
    Conditions
    Uterine Fibroids
    Interventions
    Mifegyne; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-11
    Completion
    2007-06
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUterine Fibroids
    InterventionMifegyne; placebo
    PhasePhase 1
    Registry statusCompleted

  • Brain Receptor Function in Post-Traumatic Stress Disorder

    NCT00046553 · start 2002-09

    Registered record
    Registry ID
    NCT00046553
    Conditions
    Post-Traumatic Stress Disorder
    Interventions
    RU-486 (Mifepristone)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2002-09
    Completion
    2004-10
    Enrolment
    97

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-Traumatic Stress Disorder
    InterventionRU-486 (Mifepristone)
    PhaseNot recorded
    Registry statusCompleted

  • Treatment of Schizoaffective Disorder Using Mifepristone

    NCT00725270 · start 1998-04

    Registered record
    Registry ID
    NCT00725270
    Conditions
    Psychotic Disorders; Depressive Disorder, Major; Depressive Disorder
    Interventions
    Mifepristone; Placebo Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    1998-04
    Completion
    2009-05
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsychotic Disorders; Depressive Disorder, Major; Depressive Disorder
    InterventionMifepristone; Placebo Oral Tablet
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • Termination of Pregnancy With Mifepristone and Misoprostol Versus Sulprostone

    NCT00206193

    Registered record
    Registry ID
    NCT00206193
    Conditions
    Abortion, Induced
    Interventions
    mifepristone; misoprostol; sulprostone
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion, Induced
    Interventionmifepristone; misoprostol; sulprostone
    PhaseNot recorded
    Registry statusUnknown