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AMR Drug RepurposingSmart Screeningresearch prototype

Mifepristone

FDA-approved product (tablet, oral), marketed as Korlym, Mifeprex, Mifepristone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Mifepristone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cushing syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Progesterone receptor modulators
FDA pharmacologic class
Progestin Antagonist FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA55.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli42.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae39.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Mifepristone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

-4.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Mifepristone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Surgical vs. Medical Abortion on Sexual Function After Early Pregnancy Loss

    NCT07646275 · start 2025-04-01

    Registered record
    Registry ID
    NCT07646275
    Conditions
    Early Pregnancy Loss; Abortion, Spontaneous; Miscarriage; Pregnancy, Unwanted
    Interventions
    mifepristone and misoprostol; Vacuum Aspiration
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-04-01
    Completion
    2026-01-31
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEarly Pregnancy Loss; Abortion, Spontaneous; Miscarriage; Pregnancy, Unwanted
    Interventionmifepristone and misoprostol; Vacuum Aspiration
    PhaseNot applicable
    Registry statusCompleted

  • Assessing the Efficacy and Acceptability of Two Missed Period Pills Regimens

    NCT06492889 · start 2024-07-22

    Registered record
    Registry ID
    NCT06492889
    Conditions
    Pregnancy Early; Pregnancy Related
    Interventions
    Levonorgestrel; Mifepristone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2024-07-22
    Completion
    2025-06-30
    Enrolment
    286

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy Early; Pregnancy Related
    InterventionLevonorgestrel; Mifepristone
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion

    NCT07422506 · start 2024-01-01

    Registered record
    Registry ID
    NCT07422506
    Conditions
    Missed Abortion; Early Pregnancy Failure
    Interventions
    Control group; Conventional dose of estrogen; High-dose estrogen
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-01-01
    Completion
    2035-01-01
    Enrolment
    580

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMissed Abortion; Early Pregnancy Failure
    InterventionControl group; Conventional dose of estrogen; High-dose estrogen
    PhaseNot applicable
    Registry statusRecruiting

  • Mifepristone Outpatient Labour Induction

    NCT05177510 · start 2023-08-25

    Registered record
    Registry ID
    NCT05177510
    Conditions
    Labor, Induced
    Interventions
    Mifepristone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2023-08-25
    Completion
    2027-05-31
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLabor, Induced
    InterventionMifepristone; Placebo
    PhasePhase 2
    Registry statusRecruiting

  • Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial

    NCT05322252 · start 2022-07-01

    Registered record
    Registry ID
    NCT05322252
    Conditions
    Abortion, Second Trimester; PPROM; Rupture, Spontaneous; Fetal Demise; Fetal Death; Fetal Demise From Miscarriage; Fetal Death Before 22 Weeks With Retention of Dead Fetus; Pregnancy Loss; Pregnancy Complications
    Interventions
    Mifepristone; Misoprostol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-07-01
    Completion
    2025-07-14
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion, Second Trimester; PPROM; Rupture, Spontaneous; Fetal Demise +5 more
    InterventionMifepristone; Misoprostol
    PhasePhase 4
    Registry statusCompleted

  • Breast Cancer BRCA1 Carriers: a Pilot Study

    NCT05062174 · start 2021-11-01

    Registered record
    Registry ID
    NCT05062174
    Conditions
    BRCA1 Mutation; High-grade Serous Ovarian Cancer; TNBC - Triple-Negative Breast Cancer
    Interventions
    Mifepristone 200 MG; Prophylactic mastectomy
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Withdrawn
    Start
    2021-11-01
    Completion
    2024-12-31
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBRCA1 Mutation; High-grade Serous Ovarian Cancer; TNBC - Triple-Negative Breast Cancer
    InterventionMifepristone 200 MG; Prophylactic mastectomy
    PhaseNot recorded
    Registry statusWithdrawn

  • TNF and Glucocorticoid Antagonist for GWI Associated Multi-symptom Disease Homeostasis Reset

    NCT04254627 · start 2021-09-24

    Registered record
    Registry ID
    NCT04254627
    Conditions
    Gulf War Illness
    Interventions
    Etanercept; Mifepristone
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2021-09-24
    Completion
    2025-09-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGulf War Illness
    InterventionEtanercept; Mifepristone
    PhasePhase 1
    Registry statusCompleted

  • Investigating the Potential Role of a Novel Quadrate Combination Therapy Mifepristone(Antiprogestrone), Tamoxifen, Retinoic Acid and Cannabidiol ( Selective Cyp 26 Inhibitor) for Treating Early Breast Cancer.

    NCT05016349 · start 2021-08

    Registered record
    Registry ID
    NCT05016349
    Conditions
    Breast Cancer Female
    Interventions
    All trans-retinoic acid; 13-Cis Retinoic Acid plus Tocopherol; Mifepristone; Cannabidiol; 9 cis retinoic acid; Tamoxifen; Standard therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2021-08
    Completion
    2021-12
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer Female
    InterventionAll trans-retinoic acid; 13-Cis Retinoic Acid plus Tocopherol; Mifepristone; Cannabidiol +3 more
    PhasePhase 3
    Registry statusUnknown

  • Mifepristone Dynamic Testing for Diagnosis for Central Adrenal Insufficiency

    NCT04588688 · start 2021-05-05

    Registered record
    Registry ID
    NCT04588688
    Conditions
    Central Adrenal Insufficiency; Mifepristone
    Interventions
    Mifepristone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2021-05-05
    Completion
    2021-08-01
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Adrenal Insufficiency; Mifepristone
    InterventionMifepristone
    PhasePhase 2
    Registry statusTerminated

  • Clotting Parameters After Medical Abortion

    NCT04824118 · start 2021-03-26

    Registered record
    Registry ID
    NCT04824118
    Conditions
    Abortion Early; Abortion, Complete; Abortion, Second Trimester; Termination of Pregnancy Complicated by Embolism; Venous Thromboses; Venous Thromboembolism; Venous Thromboembolic Disease; Clotting Disorder
    Interventions
    Thromboelastometry; Clotting Studies; Full Blood Count; Quantitative hCG; Pregnancy Test
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-03-26
    Completion
    2021-08-12
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion Early; Abortion, Complete; Abortion, Second Trimester; Termination of Pregnancy Complicated by Embolism +4 more
    InterventionThromboelastometry; Clotting Studies; Full Blood Count; Quantitative hCG +1 more
    PhaseNot recorded
    Registry statusCompleted

  • Mail Order Mifepristone Study

    NCT03913104 · start 2020-01-05

    Registered record
    Registry ID
    NCT03913104
    Conditions
    Abortion Early; Pregnancy Related
    Interventions
    Mifepristone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-01-05
    Completion
    2023-07-30
    Enrolment
    536

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion Early; Pregnancy Related
    InterventionMifepristone
    PhasePhase 4
    Registry statusCompleted

  • Medical Termination of II Trimester Pregnancy

    NCT03600857 · start 2018-12-10

    Registered record
    Registry ID
    NCT03600857
    Conditions
    Unwanted Pregnancy
    Interventions
    Home administration of misoprostol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-12-10
    Completion
    2023-06-30
    Enrolment
    457

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUnwanted Pregnancy
    InterventionHome administration of misoprostol
    PhasePhase 4
    Registry statusCompleted

  • Medication Abortion Via Pharmacy Dispensing

    NCT03320057 · start 2018-06-01

    Registered record
    Registry ID
    NCT03320057
    Conditions
    Pregnancy Related; Abortion Early
    Interventions
    Mifepristone; Training on mifepristone dispensing
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-06-01
    Completion
    2020-07-04
    Enrolment
    326

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy Related; Abortion Early
    InterventionMifepristone; Training on mifepristone dispensing
    PhasePhase 4
    Registry statusCompleted

  • Medical Abortion Self-Confirmation (MASC)

    NCT03148587 · start 2017-05-01

    Registered record
    Registry ID
    NCT03148587
    Conditions
    Medical Abortion
    Interventions
    Self-assessment: MLPT; Self-assessment: LSPT
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-05-01
    Completion
    2018-05-31
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMedical Abortion
    InterventionSelf-assessment: MLPT; Self-assessment: LSPT
    PhaseNot applicable
    Registry statusCompleted

  • Abraxane® With or Without Mifepristone for Advanced, Glucocorticoid Receptor-Positive, Triple-Negative Breast Cancer

    NCT02788981 · start 2017-03-28

    Registered record
    Registry ID
    NCT02788981
    Conditions
    Breast Cancer
    Interventions
    Mifepristone; Placebo; Nab-Paclitaxel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2017-03-28
    Completion
    2026-08
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionMifepristone; Placebo; Nab-Paclitaxel
    PhasePhase 2
    Registry statusActive not recruiting