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AMR Drug RepurposingSmart Screeningresearch prototype

Mifepristone

FDA-approved product (tablet, oral), marketed as Korlym, Mifeprex, Mifepristone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Mifepristone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cushing syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Progesterone receptor modulators
FDA pharmacologic class
Progestin Antagonist FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA55.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli42.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae39.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Mifepristone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

-4.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Mifepristone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Reducing the Need for In-Clinic Follow-Up for Medical Abortion in Moldova and Uzbekistan

    NCT01410266 · start 2010-09

    Registered record
    Registry ID
    NCT01410266
    Conditions
    Medical Abortion, Fetus
    Interventions
    Alternative follow-up
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-09
    Completion
    2012-10
    Enrolment
    2,400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMedical Abortion, Fetus
    InterventionAlternative follow-up
    PhasePhase 4
    Registry statusCompleted

  • A Prospective Randomized Comparison Trial on the Use of Mifepristone With Sublingual or Buccal Misoprostol for Medical Abortions of Less Than 9 Weeks Gestation

    NCT01156688 · start 2010-08

    Registered record
    Registry ID
    NCT01156688
    Conditions
    Abortion, Legal
    Interventions
    Misoprostol; Misoprostol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-08
    Completion
    2011-08
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion, Legal
    InterventionMisoprostol; Misoprostol
    PhasePhase 4
    Registry statusCompleted

  • Investigation of Mifepristone (RU486) on Stress Sensitivity and Relapse Prevention in Cocaine Dependent Patients

    NCT01134198 · start 2010-05

    Registered record
    Registry ID
    NCT01134198
    Conditions
    Cocaine Dependence
    Interventions
    Mifepristone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2010-05
    Completion
    2018-02-14
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine Dependence
    InterventionMifepristone; placebo
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Mifepristone to Treat Uterine Fibroids

    NCT01786226 · start 2010-03

    Registered record
    Registry ID
    NCT01786226
    Conditions
    Uterine Fibroids
    Interventions
    Oral administration of mifepristone 2.5 mg daily for three months; Oral administration of mifepristone 5 mg daily for three months
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2010-03
    Completion
    2012-03
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUterine Fibroids
    InterventionOral administration of mifepristone 2.5 mg daily for three months; Oral administration of mifepristone 5 mg daily for three months
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • Mifepristone Versus Laminaria Insertion for Cervical Preparation Prior to Surgical Abortion at 14-16 Weeks

    NCT00986921 · start 2009-10

    Registered record
    Registry ID
    NCT00986921
    Conditions
    Abortion
    Interventions
    mifepristone 200 mg; osmotic dilator insertion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-10
    Completion
    2011-03
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion
    Interventionmifepristone 200 mg; osmotic dilator insertion
    PhaseNot applicable
    Registry statusCompleted

  • Uptake and Acceptability of Home-use of Mifepristone for Medical Abortion

    NCT00994734 · start 2009-05

    Registered record
    Registry ID
    NCT00994734
    Conditions
    Termination of Pregnancy
    Interventions
    Mifepristone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-05
    Completion
    2011-02
    Enrolment
    615

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTermination of Pregnancy
    InterventionMifepristone
    PhaseNot applicable
    Registry statusCompleted

  • Comparing Two Regimens for Medical Abortion: Mifepristone + Misoprostol Versus Misoprostol Alone

    NCT01387256 · start 2009-05

    Registered record
    Registry ID
    NCT01387256
    Conditions
    Complete Abortion
    Interventions
    medical abortion
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-05
    Completion
    2010-07
    Enrolment
    441

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplete Abortion
    Interventionmedical abortion
    PhasePhase 4
    Registry statusCompleted

  • Developing Memory Reconsolidation Blockers as Novel Posttraumatic Stress Disorder (PTSD) Treatments

    NCT01490697 · start 2009-03

    Registered record
    Registry ID
    NCT01490697
    Conditions
    Post-traumatic Stress Disorder
    Interventions
    Mifepristone; d-Cycloserine; Placebo-matching Mifepristone; Placebo-matching d-Cycloserine (DCS)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-03
    Completion
    2015-09
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-traumatic Stress Disorder
    InterventionMifepristone; d-Cycloserine; Placebo-matching Mifepristone; Placebo-matching d-Cycloserine (DCS)
    PhasePhase 4
    Registry statusCompleted

  • Compassionate Use of Mifepristone in Brain/Nervous System and Other Cancers

    NCT00832871 · start 2008-11

    Registered record
    Registry ID
    NCT00832871
    Conditions
    Cancer
    Interventions
    Mifepristone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-11
    Completion
    2015-12
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCancer
    InterventionMifepristone
    PhaseNot applicable
    Registry statusTerminated

  • A Phase I Study to Determine the Effect of Mifepristone on the Pharmacokinetics of Fluvastatin in Healthy Volunteers

    NCT00752843 · start 2008-09

    Registered record
    Registry ID
    NCT00752843
    Conditions
    Healthy Subjects
    Interventions
    mifepristone + fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-09
    Completion
    2008-11
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Subjects
    Interventionmifepristone + fluvastatin
    PhasePhase 1
    Registry statusCompleted

  • Mifepristone 10 or 5 mg for 6 Months to Treat Uterine Fibroids

    NCT00886873 · start 2008-05

    Registered record
    Registry ID
    NCT00886873
    Conditions
    Uterine Fibroids
    Interventions
    Mifepristone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2008-05
    Completion
    2009-05
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUterine Fibroids
    InterventionMifepristone
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Intrauterine Contraception (IUC) After Medical Abortion

    NCT01537562 · start 2007-02

    Registered record
    Registry ID
    NCT01537562
    Conditions
    IUC Insertion After Medical Abortion
    Interventions
    Timing of IUC insertion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-02
    Completion
    2010-10
    Enrolment
    129

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIUC Insertion After Medical Abortion
    InterventionTiming of IUC insertion
    PhaseNot applicable
    Registry statusCompleted

  • A Randomized Trial of Buccal Compared to Oral Misoprostol Following Mifepristone for Medical Abortion up to 63 Days LMP

    NCT00386867 · start 2006-10

    Registered record
    Registry ID
    NCT00386867
    Conditions
    Abortion, Induced
    Interventions
    800 mcg misoprostol via oral or buccal administration
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-10
    Completion
    2007-03
    Enrolment
    1,200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion, Induced
    Intervention800 mcg misoprostol via oral or buccal administration
    PhaseNot applicable
    Registry statusCompleted

  • An International Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression

    NCT00128505 · start 2005-08

    Registered record
    Registry ID
    NCT00128505
    Conditions
    Major Depressive Disorder; Psychotic Disorders
    Interventions
    Mifepristone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-08
    Completion
    2006-11
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Psychotic Disorders
    InterventionMifepristone
    PhasePhase 3
    Registry statusCompleted

  • De-Medicalizing Mifepristone Medical Abortion

    NCT00120224 · start 2005-05

    Registered record
    Registry ID
    NCT00120224
    Conditions
    Medical Abortion
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2005-05
    Completion
    2007-04
    Enrolment
    4,410

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMedical Abortion
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted