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AMR Drug RepurposingSmart Screeningresearch prototype

Testosterone Enanthate

FDA-approved product (injectable, injection), marketed as Delatestryl, Testosterone Enanthate, Xyosted (Autoinjector).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Testosterone Enanthate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cancer
  • Hypogonadism
  • Hypogonadotropic hypogonadism
  • Klinefelter's syndrome
  • Neoplasm
  • Orchitis
  • Physiological sexual disorder
  • Sexual dysfunction

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
3-oxoandrosten (4) derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli28.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis24.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Testosterone Enanthate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Testosterone Enanthate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Muscle Anabolic Interventions to Accelerate Recovery From Hospitalization in Geriatric Patients

    NCT02990533 · start 2016-09

    Registered record
    Registry ID
    NCT02990533
    Conditions
    Aging
    Interventions
    Testosterone; Protein Supplement; Placebo Injection; Placebo supplement
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-09
    Completion
    2020-11-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAging
    InterventionTestosterone; Protein Supplement; Placebo Injection; Placebo supplement
    PhasePhase 1
    Registry statusCompleted

  • Safety of Subcutaneous Testosterone Enanthate in Adult Male Hypogonadism

    NCT02777242 · start 2016-06

    Registered record
    Registry ID
    NCT02777242
    Conditions
    Hypogonadism
    Interventions
    Testosterone enanthate auto-injector
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-06
    Completion
    2016-08
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypogonadism
    InterventionTestosterone enanthate auto-injector
    PhasePhase 2
    Registry statusCompleted

  • Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery

    NCT02734238 · start 2016-04

    Registered record
    Registry ID
    NCT02734238
    Conditions
    Caloric Restriction; Exercise
    Interventions
    Sesame Oil; testosterone enanthate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-04
    Completion
    2017-12
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCaloric Restriction; Exercise
    InterventionSesame Oil; testosterone enanthate
    PhasePhase 4
    Registry statusCompleted

  • Cycled Testosterone Therapy to Improve Physical Function in Frail Nursing Home Residents

    NCT02679274 · start 2016-02-16

    Registered record
    Registry ID
    NCT02679274
    Conditions
    Aging
    Interventions
    Placebo; Testosterone
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2016-02-16
    Completion
    2016-09-20
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAging
    InterventionPlacebo; Testosterone
    PhaseEarly phase 1
    Registry statusTerminated

  • The Effects of Long Term Cyclic Testosterone Administration on Muscle Function and Bone in Older Men

    NCT01417364 · start 2016-01

    Registered record
    Registry ID
    NCT01417364
    Conditions
    Sarcopenia
    Interventions
    Testosterone enanthate; Testosterone enanthate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2016-01
    Completion
    2017-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSarcopenia
    InterventionTestosterone enanthate; Testosterone enanthate; Placebo
    PhasePhase 4
    Registry statusWithdrawn

  • Subcutaneous Testosterone Project

    NCT02229617 · start 2015-07

    Registered record
    Registry ID
    NCT02229617
    Conditions
    Gender Dysphoria
    Interventions
    Subcutaneous testosterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2015-07
    Completion
    2016-05
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGender Dysphoria
    InterventionSubcutaneous testosterone
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Subcutaneous Testosterone Enanthate Safety in Adult Men Diagnosed With Hypogonadism

    NCT02504541 · start 2015-07

    Registered record
    Registry ID
    NCT02504541
    Conditions
    Hypogonadism
    Interventions
    Testosterone enanthate auto-injector
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-07
    Completion
    2016-06
    Enrolment
    133

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypogonadism
    InterventionTestosterone enanthate auto-injector
    PhasePhase 3
    Registry statusCompleted

  • Testosterone Revival Abolishes Negative Symptoms, Fosters Objective Response and Modulates Enzalutamide Resistance

    NCT02286921 · start 2015-01

    Registered record
    Registry ID
    NCT02286921
    Conditions
    Castration Resistant Metastatic Prostate Cancer
    Interventions
    Testosterone cypionate; Enzalutamide; Testosterone Enanthate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-01
    Completion
    2020-02-21
    Enrolment
    222

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCastration Resistant Metastatic Prostate Cancer
    InterventionTestosterone cypionate; Enzalutamide; Testosterone Enanthate
    PhasePhase 2
    Registry statusCompleted

  • Oral Testosterone for the Treatment of Hypogonadism in Males

    NCT02222558 · start 2014-09

    Registered record
    Registry ID
    NCT02222558
    Conditions
    Hypogonadism
    Interventions
    TSX-002
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-09
    Completion
    2015-05
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypogonadism
    InterventionTSX-002
    PhasePhase 2
    Registry statusCompleted

  • Pharmacokinetic Study of Subcutaneous Testosterone Enanthate

    NCT02233751 · start 2014-09

    Registered record
    Registry ID
    NCT02233751
    Conditions
    Hypogonadism
    Interventions
    Testosterone enanthate auto-injector
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-09
    Completion
    2014-10
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypogonadism
    InterventionTestosterone enanthate auto-injector
    PhasePhase 1
    Registry statusCompleted

  • RE-sensitizing With Supraphysiologic Testosterone to Overcome REsistance (The RESTORE Study)

    NCT02090114 · start 2014-08-25

    Registered record
    Registry ID
    NCT02090114
    Conditions
    Prostate Cancer
    Interventions
    Testosterone cypionate; Testosterone Enanthate; Abiraterone acetate; Enzalutamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-08-25
    Completion
    2021-11-11
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionTestosterone cypionate; Testosterone Enanthate; Abiraterone acetate; Enzalutamide
    PhasePhase 2
    Registry statusCompleted

  • Subcutaneous Testosterone Replacement Efficacy and Safety in Adult Men Diagnosed With Hypogonadism

    NCT02159469 · start 2014-07

    Registered record
    Registry ID
    NCT02159469
    Conditions
    Hypogonadism
    Interventions
    Testosterone enanthate auto-injector
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-07
    Completion
    2015-11
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypogonadism
    InterventionTestosterone enanthate auto-injector
    PhasePhase 3
    Registry statusCompleted

  • Pubertal Replacement In Boys Study Nebido and Testoviron Depot Treatment

    NCT05417035 · start 2014-06-01

    Registered record
    Registry ID
    NCT05417035
    Conditions
    Puberty Delayed
    Interventions
    Nebido
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-06-01
    Completion
    2020-08-01
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPuberty Delayed
    InterventionNebido
    PhaseNot applicable
    Registry statusCompleted

  • A Study to Evaluate a Skeletal-muscle Microbiopsy Technique With Dynamic Proteomic Measurement in Healthy Male Volunteers

    NCT01962454 · start 2014-05-05

    Registered record
    Registry ID
    NCT01962454
    Conditions
    Cachexia
    Interventions
    Deuterated Water; Testosterone enanthate; Placebo to match testosterone enanthate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-05-05
    Completion
    2015-03-20
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCachexia
    InterventionDeuterated Water; Testosterone enanthate; Placebo to match testosterone enanthate
    PhasePhase 1
    Registry statusCompleted

  • Safety and Efficacy of Oral LPCN 1021 in Men With Low Testosterone or Hypogonadism

    NCT02081300 · start 2014-02

    Registered record
    Registry ID
    NCT02081300
    Conditions
    Male Hypogonadism
    Interventions
    Oral testosterone undecanoate, LPCN 1021; Topical testosterone gel 1.62 %
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-02
    Completion
    2015-05
    Enrolment
    315

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMale Hypogonadism
    InterventionOral testosterone undecanoate, LPCN 1021; Topical testosterone gel 1.62 %
    PhasePhase 3
    Registry statusCompleted