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AMR Drug RepurposingSmart Screeningresearch prototype

Budesonide

FDA-approved product (aerosol, metered, nasal), marketed as Budesonide, Entocort Ec, Eohilia and 8 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Budesonide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Allergic rhinitis
  • Asthma
  • Chronic bronchitis
  • Chronic obstructive pulmonary disease
  • Crohn's disease
  • Emphysema
  • Esophageal disease
  • IGA glomerulonephritis
  • Nasal congestion
  • Rhinitis, Allergic, Perennial
  • Seasonal allergic rhinitis
  • Ulcerative colitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids acting locally; Corticosteroids, potent (group iii); Corticosteroids; Glucocorticoids
FDA pharmacologic class
Corticosteroid FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA55.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli38.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae23.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis44.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Budesonide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-9.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Budesonide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Methylprednisolone Sodium Succinate in Treating Patients With Acute Graft-versus-Host Disease of the Gastrointestinal Tract

    NCT02425813 · start 2015-10

    Registered record
    Registry ID
    NCT02425813
    Conditions
    Acute Graft Versus Host Disease; Intestinal Graft Versus Host Disease
    Interventions
    Budesonide; Methylprednisolone Sodium Succinate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2015-10
    Completion
    2016-07
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Graft Versus Host Disease; Intestinal Graft Versus Host Disease
    InterventionBudesonide; Methylprednisolone Sodium Succinate
    PhasePhase 2
    Registry statusWithdrawn

  • Budesonide Versus Fluticasone for Treatment of Eosinophilic Esophagitis

    NCT02019758 · start 2015-01-01

    Registered record
    Registry ID
    NCT02019758
    Conditions
    Eosinophilic Esophagitis
    Interventions
    Oral Viscous Budesonide; Fluticasone MDI; Placebo slurry; Placebo inhaler
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-01-01
    Completion
    2019-04
    Enrolment
    129

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEosinophilic Esophagitis
    InterventionOral Viscous Budesonide; Fluticasone MDI; Placebo slurry; Placebo inhaler
    PhasePhase 4
    Registry statusCompleted

  • A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma.

    NCT02149199 · start 2014-07-07

    Registered record
    Registry ID
    NCT02149199
    Conditions
    Asthma
    Interventions
    budesonide/formoterol 'as needed' + budesonide placebo bid; terbutaline 'as needed' + placebo budesonide bid; budesonide bid + terbutaline 'as needed'
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-07-07
    Completion
    2017-08-02
    Enrolment
    3,850

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    Interventionbudesonide/formoterol 'as needed' + budesonide placebo bid; terbutaline 'as needed' + placebo budesonide bid; budesonide bid + terbutaline 'as needed'
    PhasePhase 3
    Registry statusCompleted

  • Pharmacokinetic Study on Budesonide/Formoterol Device-metered Dry Powder Inhalers

    NCT01668121 · start 2012-08

    Registered record
    Registry ID
    NCT01668121
    Conditions
    Asthma
    Interventions
    Symbicort Turbohaler; Budesonide/formoterol Easyhaler
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-08
    Completion
    2012-11
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionSymbicort Turbohaler; Budesonide/formoterol Easyhaler
    PhasePhase 1
    Registry statusCompleted

  • Comparison of Absorption of Budesonide and Formoterol From Budesonide/Formoterol Easyhaler and Symbicort Turbuhaler

    NCT01593826 · start 2012-05

    Registered record
    Registry ID
    NCT01593826
    Conditions
    Asthma
    Interventions
    Charcoal and Budesonide/formoterol Easyhaler 320/9 microg; Charcoal and Symbicort Turbuhaler; Budesonide/formoterol Easyhaler 320/9 microg; Symbicort Turbuhaler forte
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-05
    Completion
    2012-10
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionCharcoal and Budesonide/formoterol Easyhaler 320/9 microg; Charcoal and Symbicort Turbuhaler; Budesonide/formoterol Easyhaler 320/9 microg; Symbicort Turbuhaler forte
    PhasePhase 1
    Registry statusCompleted

  • Effect of Flovent Discus vs QVAR vs Pulmicort Flexhaler on Short Term Growth

    NCT01520688 · start 2012-02

    Registered record
    Registry ID
    NCT01520688
    Conditions
    Asthma
    Interventions
    Fluticasone, Budesonide, Beclomethasone; Fluticasone, Beclomethasone, Budesonide; Budesonide, Fluticasone, Beclomethasone; Budesonide, Beclomethasone, Fluticasone; Beclomethasone, Fluticasone, Budesonide; Beclomethasone, Budesonide, Fluticasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-02
    Completion
    2016-02
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionFluticasone, Budesonide, Beclomethasone; Fluticasone, Beclomethasone, Budesonide; Budesonide, Fluticasone, Beclomethasone; Budesonide, Beclomethasone, Fluticasone +2 more
    PhasePhase 4
    Registry statusCompleted

  • A 6 Month Safety Study Comparing Symbicort With Inhaled Corticosteroid Only in Asthmatic Adults and Adolescents

    NCT01444430 · start 2011-12

    Registered record
    Registry ID
    NCT01444430
    Conditions
    Asthma
    Interventions
    Symbicort pMDI; budesonide pMDI
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-12
    Completion
    2015-10
    Enrolment
    12,460

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionSymbicort pMDI; budesonide pMDI
    PhasePhase 3
    Registry statusCompleted

  • Budesonide Effervescent Tablets vs. Viscous Budesonide Suspension vs. Placebo in Eosinophilic Esophagitis

    NCT02280616 · start 2011-06

    Registered record
    Registry ID
    NCT02280616
    Conditions
    Eosinophilic Esophagitis
    Interventions
    low dose budesonide tablet; high dose budesonide tablet; high dose budesonide suspension; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-06
    Completion
    2014-05
    Enrolment
    76

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEosinophilic Esophagitis
    Interventionlow dose budesonide tablet; high dose budesonide tablet; high dose budesonide suspension; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Sub-Sensitivity to Long-Acting Bronchodilators (LABA)

    NCT01117116 · start 2010-03

    Registered record
    Registry ID
    NCT01117116
    Conditions
    Asthma
    Interventions
    fluticasone propionate and salmeterol; budesonide and formoterol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-03
    Completion
    2013-09
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    Interventionfluticasone propionate and salmeterol; budesonide and formoterol
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis

    NCT01008423 · start 2009-11-20

    Registered record
    Registry ID
    NCT01008423
    Conditions
    Proctitis; Proctosigmoiditis
    Interventions
    Budesonide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-11-20
    Completion
    2013-03-18
    Enrolment
    281

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProctitis; Proctosigmoiditis
    InterventionBudesonide; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Research on Traditional Chinese Medicine (TCM) Clinical Treatment of the Acute Episode of Bronchial Asthma.

    NCT01293734 · start 2008-12

    Registered record
    Registry ID
    NCT01293734
    Conditions
    Bronchial Asthma
    Interventions
    warming lung and relieving asthmatic granule and Securing origin and warming lung emplastrum; clearing lung and relieving asthmatic granule and securing origin and clearing lung emplastrum; securing origin and relieving asthmatic granule and securing origin and nourishing lung emplastrum; Theophylline Sustained-release Tablets and budesonide suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-12
    Completion
    2011-02
    Enrolment
    360

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchial Asthma
    Interventionwarming lung and relieving asthmatic granule and Securing origin and warming lung emplastrum; clearing lung and relieving asthmatic granule and securing origin and clearing lung emplastrum; securing origin and relieving asthmatic granule and securing origin and nourishing lung emplastrum; Theophylline Sustained-release Tablets and budesonide suspension
    PhasePhase 2
    Registry statusCompleted

  • The Use of Oral Budesonide and Rectal Hydrocortisone for the Treatment of Active Ulcerative Colitis

    NCT00805285 · start 2008-10

    Registered record
    Registry ID
    NCT00805285
    Conditions
    Inflammatory Bowel Disease; Ulcerative Colitis
    Interventions
    Combination Oral Budesonide and Rectal Hydrocortisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2008-10
    Completion
    2010-03
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammatory Bowel Disease; Ulcerative Colitis
    InterventionCombination Oral Budesonide and Rectal Hydrocortisone
    PhasePhase 2
    Registry statusTerminated

  • CARE Network Maintenance Versus Intermittent Inhaled Steroids in Wheezing Toddlers (MIST)

    NCT00675584 · start 2008-08

    Registered record
    Registry ID
    NCT00675584
    Conditions
    Asthma
    Interventions
    Budesonide; Placebo Budesonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-08
    Completion
    2010-07
    Enrolment
    278

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionBudesonide; Placebo Budesonide
    PhasePhase 3
    Registry statusCompleted

  • Prospective Evaluation of the Efficacy of Budesonide/Formoterol in Bronchiolitis Obliterans in AHSCT

    NCT00624754 · start 2008-03

    Registered record
    Registry ID
    NCT00624754
    Conditions
    Obstructive Airway Disease
    Interventions
    Formoterol/Budesonide; lactose
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-03
    Completion
    2012-07
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObstructive Airway Disease
    InterventionFormoterol/Budesonide; lactose
    PhasePhase 2
    Registry statusCompleted

  • Evaluation of Efficacy and Safety of Symbicort® as an add-on Treatment to Spiriva® in Patients With Severe COPD.

    NCT00496470 · start 2007-05

    Registered record
    Registry ID
    NCT00496470
    Conditions
    Chronic Obstructive Pulmonary Disease, COPD
    Interventions
    Symbicort (budesonide/formoterol turbuhaler 320/9ug); Spiriva (tiotropium bromide 18ug)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-05
    Completion
    2008-06
    Enrolment
    660

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease, COPD
    InterventionSymbicort (budesonide/formoterol turbuhaler 320/9ug); Spiriva (tiotropium bromide 18ug)
    PhasePhase 4
    Registry statusCompleted