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AMR Drug RepurposingSmart Screeningresearch prototype

Betamethasone Sodium Phosphate

FDA-approved product (injectable, injection), marketed as Betamethasone Sodium Phosphate, Celestone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Betamethasone Sodium Phosphate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion
  • Ulcerative colitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids acting locally; Corticosteroids; Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA56.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli36.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae32.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Betamethasone Sodium Phosphate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Betamethasone Sodium Phosphate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Micro-Pulse Steroid Therapy as Induction Therapy in Patients With Polymyalgia Rheumatica

    NCT00982332 · start 2010-03

    Registered record
    Registry ID
    NCT00982332
    Conditions
    Polymyalgia Rheumatica
    Interventions
    Betamethasone; isotonic sodium chloride solution (placebo)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2010-03
    Completion
    2012-03
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPolymyalgia Rheumatica
    InterventionBetamethasone; isotonic sodium chloride solution (placebo)
    PhaseNot applicable
    Registry statusUnknown

  • Comparison of 2 Doses of Corticosteroid Subacromial Injections for the Treatment of Painful Shoulder

    NCT00914836 · start 2009-06

    Registered record
    Registry ID
    NCT00914836
    Conditions
    Tendonitis; Bursitis
    Interventions
    Betamethasone Sodium Phosphate; 1 cc - Betamethasone Sodium Phosphate; 2 cc - Betamethasone Sodium Phosphate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2009-06
    Completion
    2010-04
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTendonitis; Bursitis
    InterventionBetamethasone Sodium Phosphate; 1 cc - Betamethasone Sodium Phosphate; 2 cc - Betamethasone Sodium Phosphate
    PhaseNot applicable
    Registry statusWithdrawn

  • Evaluation of Diprospan Injection to the Knee on Rehabilitation of Patients After TKR of the Contralateral Knee

    NCT00542139 · start 2007-12

    Registered record
    Registry ID
    NCT00542139
    Conditions
    Osteoarthritis
    Interventions
    Betamethasone; Bupivocaine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-12
    Completion
    2008-11
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    InterventionBetamethasone; Bupivocaine
    PhasePhase 4
    Registry statusCompleted

  • ORTHOVISC Shoulder Osteoarthritis Study

    NCT00436969 · start 2006-12

    Registered record
    Registry ID
    NCT00436969
    Conditions
    Glenohumeral Osteoarthritis
    Interventions
    Orthovisc; Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-12
    Completion
    2011-08
    Enrolment
    274

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlenohumeral Osteoarthritis
    InterventionOrthovisc; Control
    PhasePhase 3
    Registry statusCompleted

  • Betamethasone to Control Postoperative Pain in Emergency Endodontic Care

    NCT02865746 · start 2004-07

    Registered record
    Registry ID
    NCT02865746
    Conditions
    Pain
    Interventions
    Bethametasone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-07
    Completion
    2005-12
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionBethametasone; Placebo
    PhaseNot applicable
    Registry statusCompleted