Leucovorin Calcium
FDA-approved product (for solution, oral), marketed as Leucovorin Calcium, Leucovorin Calcium Preservative Free, Vykoura and 1 more.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 4 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Osteosarcoma
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Detoxifying agents for antineoplastic treatment
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA52.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli67.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae43.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- M. tuberculosis54.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Leucovorin Calcium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- LinaclotideExisting use: Constipation, Constipation disorder, Irritable bowel syndrome60.5% AI-predicted activityagainst E. coli50+ registered studies
- PlecanatideExisting use: Constipation60.1% AI-predicted activityagainst E. coli15 registered studies
- Terazosin HydrochlorideExisting use: Benign prostatic hyperplasia60.0% AI-predicted activityagainst E. coli41 registered studies
- Leuprolide AcetateExisting use: Central precocious puberty, Metastatic prostate cancer, Neoplasm and 4 more59.6% AI-predicted activityagainst E. coli50+ registered studies
- Trilaciclib DihydrochlorideExisting use: Small cell lung carcinoma59.6% AI-predicted activityagainst E. coli2 registered studies
- Gonadorelin AcetateExisting use: Gonadotropin-releasing hormones, Tests for fertility disturbances59.5% AI-predicted activityagainst E. coli50+ registered studies
- Larotrectinib SulfateExisting use: Abdominal Neoplasms, Cancer, Metastasis and 1 more59.4% AI-predicted activityagainst E. coli5 registered studies
- PalbociclibExisting use: Breast cancer, Breast carcinoma, Breast neoplasm and 3 more59.1% AI-predicted activityagainst E. coli50+ registered studies
- TemsirolimusExisting use: Cancer, Clear cell renal carcinoma, Mantle cell lymphoma and 2 more59.0% AI-predicted activityagainst E. coli50+ registered studies
- Angiotensin Ii AcetateExisting use: Cardiovascular disease, Hypotension, Septic shock and 1 more58.8% AI-predicted activityagainst E. coli10 registered studies
- Terlipressin AcetateExisting use: Hepatorenal syndrome, Kidney failure, Renal insufficiency58.8% AI-predicted activityagainst E. coli7 registered studies
- Nafarelin AcetateExisting use: Endometriosis58.6% AI-predicted activityagainst E. coli12 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Chemoradiotherapy in Patients With Esophageal Adenocarcinoma
NCT02037048 · start 2014-02-10
Registered record
- Registry ID
- NCT02037048
- Conditions
- Adenocarcinoma of the Esophagus; Adenocarcinoma of the Gastroesophageal Junction; Adenocarcinoma of the Gastric Cardia; Stage IIIA Esophageal Cancer; Stage IIIB Esophageal Cancer; Stage IIIC Esophageal Cancer
- Interventions
- oxaliplatin; leucovorin calcium; fluorouracil; therapeutic conventional surgery; radiation therapy; carboplatin; paclitaxel
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Unknown
- Start
- 2014-02-10
- Completion
- 2025-10-01
- Enrolment
- 63
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAdenocarcinoma of the Esophagus; Adenocarcinoma of the Gastroesophageal Junction; Adenocarcinoma of the Gastric Cardia; Stage IIIA Esophageal Cancer +2 moreInterventionoxaliplatin; leucovorin calcium; fluorouracil; therapeutic conventional surgery +3 morePhasePhase 2Registry statusUnknownCPI-613 and Combination Chemotherapy in Treating Patients With Metastatic Pancreatic Cancer
NCT01835041 · start 2013-04
Registered record
- Registry ID
- NCT01835041
- Conditions
- Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer
- Interventions
- 6,8-bis(benzylthio)octanoic acid; oxaliplatin; leucovorin calcium; irinotecan hydrochloride; fluorouracil; laboratory biomarker analysis
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2013-04
- Completion
- 2023-03-16
- Enrolment
- 21
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAcinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic CancerIntervention6,8-bis(benzylthio)octanoic acid; oxaliplatin; leucovorin calcium; irinotecan hydrochloride +2 morePhasePhase 1Registry statusCompletedMetformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer
NCT01666730 · start 2013-02-21
Registered record
- Registry ID
- NCT01666730
- Conditions
- Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer
- Interventions
- metformin hydrochloride; oxaliplatin; leucovorin calcium; fluorouracil; laboratory biomarker analysis
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2013-02-21
- Completion
- 2018-08-01
- Enrolment
- 50
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAcinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic CancerInterventionmetformin hydrochloride; oxaliplatin; leucovorin calcium; fluorouracil +1 morePhasePhase 2Registry statusCompletedLiposome-encapsulated Irinotecan Hydrochloride PEP02 or Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil as Second-Line Therapy in Treating Patients With Metastatic Colorectal Cancer
NCT01375816 · start 2011-05
Registered record
- Registry ID
- NCT01375816
- Conditions
- Colorectal Cancer
- Interventions
- FOLFIRI 1-Bevacizumab; fluorouracil; irinotecan hydrochloride; leucovorin calcium; liposome-encapsulated irinotecan hydrochloride PEP02; Bevacizumab
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Terminated
- Start
- 2011-05
- Completion
- 2014-12
- Enrolment
- 55
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionFOLFIRI 1-Bevacizumab; fluorouracil; irinotecan hydrochloride; leucovorin calcium +2 morePhasePhase 2Registry statusTerminatedCediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers
NCT01229111 · start 2010-10
Registered record
- Registry ID
- NCT01229111
- Conditions
- Adult Primary Cholangiocellular Carcinoma; Advanced Adult Primary Liver Cancer; Cholangiocarcinoma of the Extrahepatic Bile Duct; Cholangiocarcinoma of the Gallbladder; Localized Unresectable Adult Primary Liver Cancer; Periampullary Adenocarcinoma; Recurrent Adult Primary Liver Cancer; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer
- Interventions
- cediranib maleate; oxaliplatin; leucovorin calcium; fluorouracil
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Terminated
- Start
- 2010-10
- Completion
- 2014-03
- Enrolment
- 14
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAdult Primary Cholangiocellular Carcinoma; Advanced Adult Primary Liver Cancer; Cholangiocarcinoma of the Extrahepatic Bile Duct; Cholangiocarcinoma of the Gallbladder +7 moreInterventioncediranib maleate; oxaliplatin; leucovorin calcium; fluorouracilPhasePhase 2Registry statusTerminatedVorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That Has Not Responded to Previous Treatment
NCT00942266 · start 2009-07
Registered record
- Registry ID
- NCT00942266
- Conditions
- Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer
- Interventions
- fluorouracil; leucovorin calcium; vorinostat; pharmacological study
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2009-07
- Completion
- 2011-12
- Enrolment
- 58
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAdenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Recurrent Colon Cancer; Recurrent Rectal Cancer +2 moreInterventionfluorouracil; leucovorin calcium; vorinostat; pharmacological studyPhasePhase 2Registry statusCompletedTegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery
NCT00660894 · start 2008-04
Registered record
- Registry ID
- NCT00660894
- Conditions
- Colorectal Cancer
- Interventions
- folinate calcium; tegafur-uracil; tegafur-gimeracil-oteracil potassium
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2008-04
- Completion
- 2015-07
- Enrolment
- 1,535
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionfolinate calcium; tegafur-uracil; tegafur-gimeracil-oteracil potassiumPhasePhase 3Registry statusCompletedSystemic Chemotherapy With or Without Intraperitoneal Chemohyperthermia in Treating Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer
NCT00769405 · start 2008-02
Registered record
- Registry ID
- NCT00769405
- Conditions
- Colorectal Cancer; Primary Peritoneal Cavity Cancer
- Interventions
- fluorouracil; leucovorin calcium; oxaliplatin; hyperthermia treatment
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2008-02
- Completion
- Not recorded
- Enrolment
- 264
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal Cancer; Primary Peritoneal Cavity CancerInterventionfluorouracil; leucovorin calcium; oxaliplatin; hyperthermia treatmentPhasePhase 3Registry statusCompletedUracil and Tegafur/Leucovorin (UFT/LV) Versus UFT/LV+ Polysaccharide-K (PSK) for Stage IIIa/IIIb Colorectal Cancer
NCT00497107 · start 2007-07
Registered record
- Registry ID
- NCT00497107
- Conditions
- Colorectal Cancer
- Interventions
- UFT, Calcium Folinate, PSK; UFT, Calcium Folinate
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Unknown
- Start
- 2007-07
- Completion
- 2013-05
- Enrolment
- 300
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionUFT, Calcium Folinate, PSK; UFT, Calcium FolinatePhasePhase 3Registry statusUnknownHepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
NCT00492999 · start 2007-05
Registered record
- Registry ID
- NCT00492999
- Conditions
- Colorectal Cancer; Metastatic Cancer
- Interventions
- dexamethasone; floxuridine; fluorouracil; irinotecan hydrochloride; leucovorin calcium; oxaliplatin
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Active not recruiting
- Start
- 2007-05
- Completion
- 2027-05
- Enrolment
- 64
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal Cancer; Metastatic CancerInterventiondexamethasone; floxuridine; fluorouracil; irinotecan hydrochloride +2 morePhasePhase 2Registry statusActive not recruitingRituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma
NCT00392834 · start 2006-09
Registered record
- Registry ID
- NCT00392834
- Conditions
- Lymphoma
- Interventions
- filgrastim; pegfilgrastim; rituximab; cyclophosphamide; cytarabine; doxorubicin hydrochloride; etoposide; ifosfamide; leucovorin calcium; liposomal cytarabine; methotrexate; therapeutic hydrocortisone; vincristine sulfate
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2006-09
- Completion
- 2013-07
- Enrolment
- 34
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLymphomaInterventionfilgrastim; pegfilgrastim; rituximab; cyclophosphamide +9 morePhasePhase 2Registry statusCompletedImatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
NCT00618501 · start 2005-10
Registered record
- Registry ID
- NCT00618501
- Conditions
- Leukemia
- Interventions
- cytarabine; daunorubicin hydrochloride; etoposide; imatinib mesylate; leucovorin calcium; methotrexate; prednisolone; therapeutic hydrocortisone; vincristine sulfate; allogeneic hematopoietic stem cell transplantation
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2005-10
- Completion
- 2009-01
- Enrolment
- 50
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLeukemiaInterventioncytarabine; daunorubicin hydrochloride; etoposide; imatinib mesylate +6 morePhasePhase 2Registry statusCompletedBevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer
NCT00098787 · start 2005-09-08
Registered record
- Registry ID
- NCT00098787
- Conditions
- Colorectal Cancer
- Interventions
- bevacizumab; fluorouracil; irinotecan hydrochloride; leucovorin calcium; Oxaliplatin
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2005-09-08
- Completion
- 2015-04
- Enrolment
- 247
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionbevacizumab; fluorouracil; irinotecan hydrochloride; leucovorin calcium +1 morePhasePhase 2Registry statusCompletedStudy of Rituximab-HCVAD Alternating With Rituximab-Methotrexate-Cytarabine Versus Standard Rituximab-CHOP Every 21 Days for Patients With Newly Diagnosed High Risk Aggressive B-Cell Non-Hodgkin's Lymphomas in Patients 60 Years Old or Younger
NCT00290498 · start 2005-08-01
Registered record
- Registry ID
- NCT00290498
- Conditions
- Lymphoma
- Interventions
- Rituximab; Cyclophosphamide; Doxorubicin; Vincristine; Dexamethasone; Methotrexate; Cytarabine; Prednisone
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2005-08-01
- Completion
- 2017-08-11
- Enrolment
- 67
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLymphomaInterventionRituximab; Cyclophosphamide; Doxorubicin; Vincristine +4 morePhasePhase 2Registry statusCompletedFluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer
NCT00096278 · start 2004-09-15
Registered record
- Registry ID
- NCT00096278
- Conditions
- Colon Adenocarcinoma; Stage IIA Colon Cancer AJCC v7; Stage IIB Colon Cancer AJCC v7; Stage IIC Colon Cancer AJCC v7; Stage IIIA Colon Cancer AJCC v7; Stage IIIB Colon Cancer AJCC v7; Stage IIIC Colon Cancer AJCC v7
- Interventions
- Bevacizumab; Fluorouracil; Leucovorin Calcium; Oxaliplatin
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2004-09-15
- Completion
- 2012-12-31
- Enrolment
- 2,710
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColon Adenocarcinoma; Stage IIA Colon Cancer AJCC v7; Stage IIB Colon Cancer AJCC v7; Stage IIC Colon Cancer AJCC v7 +3 moreInterventionBevacizumab; Fluorouracil; Leucovorin Calcium; OxaliplatinPhasePhase 3Registry statusCompleted