Leucovorin Calcium
FDA-approved product (for solution, oral), marketed as Leucovorin Calcium, Leucovorin Calcium Preservative Free, Vykoura and 1 more.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 4 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Osteosarcoma
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Detoxifying agents for antineoplastic treatment
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA, E. coli and K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA52.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli67.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae43.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- M. tuberculosis54.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Leucovorin Calcium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Mefloquine HydrochlorideExisting use: Malaria, Plasmodium falciparum malaria, Plasmodium vivax malaria81.8% AI-predicted activityagainst M. tuberculosisLab records exist8 registered studies
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery
NCT00416767 · start 2004-05
Registered record
- Registry ID
- NCT00416767
- Conditions
- Gastrointestinal Carcinoid Tumor; Islet Cell Tumor; Neoplastic Syndrome
- Interventions
- fluorouracil; irinotecan hydrochloride; leucovorin calcium
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2004-05
- Completion
- 2007-07
- Enrolment
- 20
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionGastrointestinal Carcinoid Tumor; Islet Cell Tumor; Neoplastic SyndromeInterventionfluorouracil; irinotecan hydrochloride; leucovorin calciumPhasePhase 2Registry statusCompletedCombination Chemotherapy and Oblimersen in Treating Patients With Advanced Colorectal Cancer
NCT00055822 · start 2002-10
Registered record
- Registry ID
- NCT00055822
- Conditions
- Colorectal Cancer
- Interventions
- oblimersen sodium; fluorouracil; leucovorin calcium; oxaliplatin
- Study type
- INTERVENTIONAL
- Phase
- Phase 1 / Phase 2
- Registry status
- Completed
- Start
- 2002-10
- Completion
- 2004-10
- Enrolment
- 16
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionoblimersen sodium; fluorouracil; leucovorin calcium; oxaliplatinPhasePhase 1 / Phase 2Registry statusCompletedRituximab, Chemotherapy, and Filgrastim in Treating Patients With Burkitt's Lymphoma or Burkitt's Leukemia
NCT00039130 · start 2002-05
Registered record
- Registry ID
- NCT00039130
- Conditions
- Leukemia; Lymphoma
- Interventions
- filgrastim; rituximab; cyclophosphamide; cytarabine; dexamethasone; doxorubicin hydrochloride; etoposide; ifosfamide; leucovorin calcium; methotrexate; prednisone; vincristine sulfate; Allopurinol
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2002-05
- Completion
- 2014-10
- Enrolment
- 105
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLeukemia; LymphomaInterventionfilgrastim; rituximab; cyclophosphamide; cytarabine +9 morePhasePhase 2Registry statusCompletedZD 1839 Plus Combination Chemotherapy in Treating Patients With Locally Advanced, Locally Recurrent, or Metastatic Colorectal Cancer
NCT00026364 · start 2001-11
Registered record
- Registry ID
- NCT00026364
- Conditions
- Colorectal Cancer
- Interventions
- fluorouracil; gefitinib; irinotecan hydrochloride; leucovorin calcium
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2001-11
- Completion
- Not recorded
- Enrolment
- 22
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionfluorouracil; gefitinib; irinotecan hydrochloride; leucovorin calciumPhasePhase 1Registry statusCompletedCombination Chemotherapy in Treating Patients With Colon Cancer
NCT00046995 · start 2001-05
Registered record
- Registry ID
- NCT00046995
- Conditions
- Colorectal Cancer
- Interventions
- carboplatin; fluorouracil; leucovorin calcium; adjuvant therapy
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Unknown
- Start
- 2001-05
- Completion
- Not recorded
- Enrolment
- 800
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventioncarboplatin; fluorouracil; leucovorin calcium; adjuvant therapyPhasePhase 3Registry statusUnknownCetuximab Plus Combination Chemotherapy in Treating Patients With Stage IV Colorectal Cancer
NCT00020917 · start 2001-02
Registered record
- Registry ID
- NCT00020917
- Conditions
- Colorectal Cancer
- Interventions
- cetuximab; fluorouracil; irinotecan hydrochloride; leucovorin calcium
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2001-02
- Completion
- 2004-02
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventioncetuximab; fluorouracil; irinotecan hydrochloride; leucovorin calciumPhasePhase 2Registry statusCompletedCombination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer
NCT00021281 · start 2000-12
Registered record
- Registry ID
- NCT00021281
- Conditions
- Colorectal Cancer
- Interventions
- FOLFIRI regimen; fluorouracil; irinotecan hydrochloride; leucovorin calcium; semaxanib
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Unknown
- Start
- 2000-12
- Completion
- Not recorded
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionFOLFIRI regimen; fluorouracil; irinotecan hydrochloride; leucovorin calcium +1 morePhasePhase 3Registry statusUnknownBortezomib, Fluorouracil, and Leucovorin Calcium in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery
NCT00007878 · start 2000-09
Registered record
- Registry ID
- NCT00007878
- Conditions
- Unspecified Adult Solid Tumor, Protocol Specific
- Interventions
- bortezomib; fluorouracil; leucovorin calcium; pharmacological study; laboratory biomarker analysis
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2000-09
- Completion
- Not recorded
- Enrolment
- 30
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionUnspecified Adult Solid Tumor, Protocol SpecificInterventionbortezomib; fluorouracil; leucovorin calcium; pharmacological study +1 morePhasePhase 1Registry statusCompletedCombination Chemotherapy in Treating Patients With Colorectal Cancer
NCT00006103 · start 2000-07
Registered record
- Registry ID
- NCT00006103
- Conditions
- Colorectal Cancer
- Interventions
- fluorouracil; irinotecan hydrochloride; leucovorin calcium
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2000-07
- Completion
- 2002-04
- Enrolment
- 400
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionfluorouracil; irinotecan hydrochloride; leucovorin calciumPhasePhase 3Registry statusCompletedCombination Chemotherapy in Treating Patients With Stage IIB, Stage III, or Stage IV Cancer of the Nasopharynx
NCT00004164 · start 1999-08
Registered record
- Registry ID
- NCT00004164
- Conditions
- Head and Neck Cancer
- Interventions
- filgrastim; cisplatin; docetaxel; fluorouracil; leucovorin calcium; radiation therapy
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Unknown
- Start
- 1999-08
- Completion
- Not recorded
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHead and Neck CancerInterventionfilgrastim; cisplatin; docetaxel; fluorouracil +2 morePhasePhase 2Registry statusUnknownChemotherapy in Treating Patients With Cancer of Unknown Primary Origin
NCT00003558 · start 1998-08
Registered record
- Registry ID
- NCT00003558
- Conditions
- Carcinoma of Unknown Primary
- Interventions
- carboplatin; etoposide; fluorouracil; leucovorin calcium; paclitaxel
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Unknown
- Start
- 1998-08
- Completion
- Not recorded
- Enrolment
- 140
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCarcinoma of Unknown PrimaryInterventioncarboplatin; etoposide; fluorouracil; leucovorin calcium +1 morePhasePhase 3Registry statusUnknownCombination Chemotherapy in Treating Patients With Recurrent, Refractory, or Metastatic Solid Tumors or Lymphomas
NCT00019513 · start 1998-08
Registered record
- Registry ID
- NCT00019513
- Conditions
- Colorectal Cancer; Esophageal Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Liver Cancer; Lung Cancer; Lymphoma; Pancreatic Cancer; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific
- Interventions
- fluorouracil; gemcitabine hydrochloride; leucovorin calcium
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 1998-08
- Completion
- 2004-06
- Enrolment
- 108
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal Cancer; Esophageal Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer +6 moreInterventionfluorouracil; gemcitabine hydrochloride; leucovorin calciumPhasePhase 1Registry statusCompletedRemoval of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation
NCT00005641 · start 1997-09
Registered record
- Registry ID
- NCT00005641
- Conditions
- Chronic Myeloproliferative Disorders; Graft Versus Host Disease; Leukemia; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes
- Interventions
- anti-thymocyte globulin; busulfan; cyclophosphamide; cyclosporine; leucovorin calcium; methotrexate; methylprednisolone; allogeneic bone marrow transplantation; in vitro-treated bone marrow transplantation; radiation therapy
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Terminated
- Start
- 1997-09
- Completion
- 2000-09
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Myeloproliferative Disorders; Graft Versus Host Disease; Leukemia; Multiple Myeloma and Plasma Cell Neoplasm +1 moreInterventionanti-thymocyte globulin; busulfan; cyclophosphamide; cyclosporine +6 morePhasePhase 2Registry statusTerminatedCombination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer
NCT00003001 · start 1997-04
Registered record
- Registry ID
- NCT00003001
- Conditions
- Colorectal Cancer
- Interventions
- fluorouracil; gemcitabine hydrochloride; leucovorin calcium
- Study type
- INTERVENTIONAL
- Phase
- Phase 1 / Phase 2
- Registry status
- Unknown
- Start
- 1997-04
- Completion
- Not recorded
- Enrolment
- 63
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionfluorouracil; gemcitabine hydrochloride; leucovorin calciumPhasePhase 1 / Phase 2Registry statusUnknownCombination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia
NCT00002816 · start 1996-12
Registered record
- Registry ID
- NCT00002816
- Conditions
- Leukemia
- Interventions
- cytarabine; dexamethasone; etoposide; idarubicin; ifosfamide; leucovorin calcium; mesna; pegaspargase; therapeutic hydrocortisone; thioguanine; vincristine sulfate; low-LET cobalt-60 gamma ray therapy; low-LET electron therapy; low-LET photon therapy; Methotrexate
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 1996-12
- Completion
- 2006-04
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLeukemiaInterventioncytarabine; dexamethasone; etoposide; idarubicin +11 morePhasePhase 3Registry statusCompleted