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AMR Drug RepurposingSmart Screeningresearch prototype

Leucovorin Calcium

FDA-approved product (for solution, oral), marketed as Leucovorin Calcium, Leucovorin Calcium Preservative Free, Vykoura and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Leucovorin Calcium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Osteosarcoma

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Detoxifying agents for antineoplastic treatment
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA, E. coli and K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli67.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae43.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis54.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Leucovorin Calcium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Leucovorin Calcium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery

    NCT00416767 · start 2004-05

    Registered record
    Registry ID
    NCT00416767
    Conditions
    Gastrointestinal Carcinoid Tumor; Islet Cell Tumor; Neoplastic Syndrome
    Interventions
    fluorouracil; irinotecan hydrochloride; leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-05
    Completion
    2007-07
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastrointestinal Carcinoid Tumor; Islet Cell Tumor; Neoplastic Syndrome
    Interventionfluorouracil; irinotecan hydrochloride; leucovorin calcium
    PhasePhase 2
    Registry statusCompleted

  • Combination Chemotherapy and Oblimersen in Treating Patients With Advanced Colorectal Cancer

    NCT00055822 · start 2002-10

    Registered record
    Registry ID
    NCT00055822
    Conditions
    Colorectal Cancer
    Interventions
    oblimersen sodium; fluorouracil; leucovorin calcium; oxaliplatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2002-10
    Completion
    2004-10
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventionoblimersen sodium; fluorouracil; leucovorin calcium; oxaliplatin
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Rituximab, Chemotherapy, and Filgrastim in Treating Patients With Burkitt's Lymphoma or Burkitt's Leukemia

    NCT00039130 · start 2002-05

    Registered record
    Registry ID
    NCT00039130
    Conditions
    Leukemia; Lymphoma
    Interventions
    filgrastim; rituximab; cyclophosphamide; cytarabine; dexamethasone; doxorubicin hydrochloride; etoposide; ifosfamide; leucovorin calcium; methotrexate; prednisone; vincristine sulfate; Allopurinol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2002-05
    Completion
    2014-10
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia; Lymphoma
    Interventionfilgrastim; rituximab; cyclophosphamide; cytarabine +9 more
    PhasePhase 2
    Registry statusCompleted

  • ZD 1839 Plus Combination Chemotherapy in Treating Patients With Locally Advanced, Locally Recurrent, or Metastatic Colorectal Cancer

    NCT00026364 · start 2001-11

    Registered record
    Registry ID
    NCT00026364
    Conditions
    Colorectal Cancer
    Interventions
    fluorouracil; gefitinib; irinotecan hydrochloride; leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2001-11
    Completion
    Not recorded
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventionfluorouracil; gefitinib; irinotecan hydrochloride; leucovorin calcium
    PhasePhase 1
    Registry statusCompleted

  • Combination Chemotherapy in Treating Patients With Colon Cancer

    NCT00046995 · start 2001-05

    Registered record
    Registry ID
    NCT00046995
    Conditions
    Colorectal Cancer
    Interventions
    carboplatin; fluorouracil; leucovorin calcium; adjuvant therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2001-05
    Completion
    Not recorded
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventioncarboplatin; fluorouracil; leucovorin calcium; adjuvant therapy
    PhasePhase 3
    Registry statusUnknown

  • Cetuximab Plus Combination Chemotherapy in Treating Patients With Stage IV Colorectal Cancer

    NCT00020917 · start 2001-02

    Registered record
    Registry ID
    NCT00020917
    Conditions
    Colorectal Cancer
    Interventions
    cetuximab; fluorouracil; irinotecan hydrochloride; leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2001-02
    Completion
    2004-02
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventioncetuximab; fluorouracil; irinotecan hydrochloride; leucovorin calcium
    PhasePhase 2
    Registry statusCompleted

  • Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer

    NCT00021281 · start 2000-12

    Registered record
    Registry ID
    NCT00021281
    Conditions
    Colorectal Cancer
    Interventions
    FOLFIRI regimen; fluorouracil; irinotecan hydrochloride; leucovorin calcium; semaxanib
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2000-12
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    InterventionFOLFIRI regimen; fluorouracil; irinotecan hydrochloride; leucovorin calcium +1 more
    PhasePhase 3
    Registry statusUnknown

  • Bortezomib, Fluorouracil, and Leucovorin Calcium in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery

    NCT00007878 · start 2000-09

    Registered record
    Registry ID
    NCT00007878
    Conditions
    Unspecified Adult Solid Tumor, Protocol Specific
    Interventions
    bortezomib; fluorouracil; leucovorin calcium; pharmacological study; laboratory biomarker analysis
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2000-09
    Completion
    Not recorded
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUnspecified Adult Solid Tumor, Protocol Specific
    Interventionbortezomib; fluorouracil; leucovorin calcium; pharmacological study +1 more
    PhasePhase 1
    Registry statusCompleted

  • Combination Chemotherapy in Treating Patients With Colorectal Cancer

    NCT00006103 · start 2000-07

    Registered record
    Registry ID
    NCT00006103
    Conditions
    Colorectal Cancer
    Interventions
    fluorouracil; irinotecan hydrochloride; leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2000-07
    Completion
    2002-04
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventionfluorouracil; irinotecan hydrochloride; leucovorin calcium
    PhasePhase 3
    Registry statusCompleted

  • Combination Chemotherapy in Treating Patients With Stage IIB, Stage III, or Stage IV Cancer of the Nasopharynx

    NCT00004164 · start 1999-08

    Registered record
    Registry ID
    NCT00004164
    Conditions
    Head and Neck Cancer
    Interventions
    filgrastim; cisplatin; docetaxel; fluorouracil; leucovorin calcium; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    1999-08
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHead and Neck Cancer
    Interventionfilgrastim; cisplatin; docetaxel; fluorouracil +2 more
    PhasePhase 2
    Registry statusUnknown

  • Chemotherapy in Treating Patients With Cancer of Unknown Primary Origin

    NCT00003558 · start 1998-08

    Registered record
    Registry ID
    NCT00003558
    Conditions
    Carcinoma of Unknown Primary
    Interventions
    carboplatin; etoposide; fluorouracil; leucovorin calcium; paclitaxel
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    1998-08
    Completion
    Not recorded
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarcinoma of Unknown Primary
    Interventioncarboplatin; etoposide; fluorouracil; leucovorin calcium +1 more
    PhasePhase 3
    Registry statusUnknown

  • Combination Chemotherapy in Treating Patients With Recurrent, Refractory, or Metastatic Solid Tumors or Lymphomas

    NCT00019513 · start 1998-08

    Registered record
    Registry ID
    NCT00019513
    Conditions
    Colorectal Cancer; Esophageal Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Liver Cancer; Lung Cancer; Lymphoma; Pancreatic Cancer; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific
    Interventions
    fluorouracil; gemcitabine hydrochloride; leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    1998-08
    Completion
    2004-06
    Enrolment
    108

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer; Esophageal Cancer; Extrahepatic Bile Duct Cancer; Gallbladder Cancer +6 more
    Interventionfluorouracil; gemcitabine hydrochloride; leucovorin calcium
    PhasePhase 1
    Registry statusCompleted

  • Removal of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation

    NCT00005641 · start 1997-09

    Registered record
    Registry ID
    NCT00005641
    Conditions
    Chronic Myeloproliferative Disorders; Graft Versus Host Disease; Leukemia; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes
    Interventions
    anti-thymocyte globulin; busulfan; cyclophosphamide; cyclosporine; leucovorin calcium; methotrexate; methylprednisolone; allogeneic bone marrow transplantation; in vitro-treated bone marrow transplantation; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    1997-09
    Completion
    2000-09
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Myeloproliferative Disorders; Graft Versus Host Disease; Leukemia; Multiple Myeloma and Plasma Cell Neoplasm +1 more
    Interventionanti-thymocyte globulin; busulfan; cyclophosphamide; cyclosporine +6 more
    PhasePhase 2
    Registry statusTerminated

  • Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer

    NCT00003001 · start 1997-04

    Registered record
    Registry ID
    NCT00003001
    Conditions
    Colorectal Cancer
    Interventions
    fluorouracil; gemcitabine hydrochloride; leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    1997-04
    Completion
    Not recorded
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventionfluorouracil; gemcitabine hydrochloride; leucovorin calcium
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia

    NCT00002816 · start 1996-12

    Registered record
    Registry ID
    NCT00002816
    Conditions
    Leukemia
    Interventions
    cytarabine; dexamethasone; etoposide; idarubicin; ifosfamide; leucovorin calcium; mesna; pegaspargase; therapeutic hydrocortisone; thioguanine; vincristine sulfate; low-LET cobalt-60 gamma ray therapy; low-LET electron therapy; low-LET photon therapy; Methotrexate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1996-12
    Completion
    2006-04
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia
    Interventioncytarabine; dexamethasone; etoposide; idarubicin +11 more
    PhasePhase 3
    Registry statusCompleted