Cidofovir
FDA-approved product (solution, intravenous), marketed as Cidofovir, Vistide.
- Registered studies
- 43
- Lab records
- 0
- Pathogens at ≥40%
- 0 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Cytomegalovirus Retinitis
- Inborn error of immunity
- Viral disease
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Nucleosides and nucleotides excl. reverse transcriptase inhibitors
- Anti-infective classification
- Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AB12
Repurposing investigation
No supported pathogen reaches ≥40% AI-predicted activity for Cidofovir, so it is not among the repurposing candidates. Its predictions are shown below.
AI-predicted activity
AI prediction · nothing measured- MRSA28.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli19.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae17.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis33.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
43registered studies name this medicine, for any condition. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Cidofovir with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Pafolacianine SodiumExisting use: Other diagnostic agents61.4% AI-predicted activityagainst E. coli1 registered study
- LinaclotideExisting use: Constipation, Constipation disorder, Irritable bowel syndrome60.5% AI-predicted activityagainst E. coli50+ registered studies
- PlecanatideExisting use: Constipation60.1% AI-predicted activityagainst E. coli15 registered studies
- Terazosin HydrochlorideExisting use: Benign prostatic hyperplasia60.0% AI-predicted activityagainst E. coli41 registered studies
- Leuprolide AcetateExisting use: Central precocious puberty, Metastatic prostate cancer, Neoplasm and 4 more59.6% AI-predicted activityagainst E. coli50+ registered studies
- Trilaciclib DihydrochlorideExisting use: Small cell lung carcinoma59.6% AI-predicted activityagainst E. coli2 registered studies
- Gonadorelin AcetateExisting use: Gonadotropin-releasing hormones, Tests for fertility disturbances59.5% AI-predicted activityagainst E. coli50+ registered studies
- Larotrectinib SulfateExisting use: Abdominal Neoplasms, Cancer, Metastasis and 1 more59.4% AI-predicted activityagainst E. coli5 registered studies
- PalbociclibExisting use: Breast cancer, Breast carcinoma, Breast neoplasm and 3 more59.1% AI-predicted activityagainst E. coli50+ registered studies
- TemsirolimusExisting use: Cancer, Clear cell renal carcinoma, Mantle cell lymphoma and 2 more59.0% AI-predicted activityagainst E. coli50+ registered studies
- Angiotensin Ii AcetateExisting use: Cardiovascular disease, Hypotension, Septic shock and 1 more58.8% AI-predicted activityagainst E. coli10 registered studies
- Terlipressin AcetateExisting use: Hepatorenal syndrome, Kidney failure, Renal insufficiency58.8% AI-predicted activityagainst E. coli7 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Studies of the Ocular Complications of AIDS (SOCA)--HPMPC Peripheral CMV Retinitis Trial (HPCRT)
NCT00000142 · start 1994-04
Registered record
- Registry ID
- NCT00000142
- Conditions
- HIV Infections; CMV Cytomegalovirus Retinitis
- Interventions
- Cidofovir
- Study type
- INTERVENTIONAL
- Phase
- Phase 2 / Phase 3
- Registry status
- Completed
- Start
- 1994-04
- Completion
- 1996-02
- Enrolment
- 64
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV Infections; CMV Cytomegalovirus RetinitisInterventionCidofovirPhasePhase 2 / Phase 3Registry statusCompletedHPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol
NCT00000799
Registered record
- Registry ID
- NCT00000799
- Conditions
- Cytomegalovirus Retinitis; HIV Infections
- Interventions
- Cidofovir; Probenecid
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 1996-04
- Enrolment
- 100
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCytomegalovirus Retinitis; HIV InfectionsInterventionCidofovir; ProbenecidPhaseNot applicableRegistry statusCompletedA Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease
NCT00000881
Registered record
- Registry ID
- NCT00000881
- Conditions
- Cytomegalovirus Infections; Cytomegalovirus Retinitis; HIV Infections
- Interventions
- Cidofovir; Probenecid
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Withdrawn
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 0
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCytomegalovirus Infections; Cytomegalovirus Retinitis; HIV InfectionsInterventionCidofovir; ProbenecidPhasePhase 1Registry statusWithdrawnComparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis
NCT00000894
Registered record
- Registry ID
- NCT00000894
- Conditions
- Cytomegalovirus Retinitis; HIV Infections
- Interventions
- Cidofovir; Probenecid; Ganciclovir
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 300
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCytomegalovirus Retinitis; HIV InfectionsInterventionCidofovir; Probenecid; GanciclovirPhasePhase 4Registry statusCompletedA Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients
NCT00000945
Registered record
- Registry ID
- NCT00000945
- Conditions
- HIV Infections; Leukoencephalopathy, Progressive Multifocal
- Interventions
- Cidofovir; Probenecid
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2001-03
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV Infections; Leukoencephalopathy, Progressive MultifocalInterventionCidofovir; ProbenecidPhaseNot applicableRegistry statusCompletedTreatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)
NCT00001126
Registered record
- Registry ID
- NCT00001126
- Conditions
- Papilloma
- Interventions
- Cidofovir
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- Not recorded
- Completion
- 2005-11
- Enrolment
- 36
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPapillomaInterventionCidofovirPhasePhase 1Registry statusCompletedA Phase I/II Study of the Safety and Efficacy of Topical 1-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine Dihydrate (Cidofovir; HPMPC) in the Treatment of Refractory Mucocutaneous Herpes Simplex Disease in Patients With AIDS
NCT00002116
Registered record
- Registry ID
- NCT00002116
- Conditions
- Herpes Simplex; HIV Infections
- Interventions
- Cidofovir
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 30
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHerpes Simplex; HIV InfectionsInterventionCidofovirPhasePhase 1Registry statusCompletedAn Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS
NCT00002142
Registered record
- Registry ID
- NCT00002142
- Conditions
- Cytomegalovirus Retinitis; HIV Infections
- Interventions
- Cidofovir; Probenecid
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 100
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCytomegalovirus Retinitis; HIV InfectionsInterventionCidofovir; ProbenecidPhaseNot applicableRegistry statusCompletedCidofovir as a Treatment for Herpes Simplex in Patients With AIDS
NCT00002181
Registered record
- Registry ID
- NCT00002181
- Conditions
- Herpes Simplex; HIV Infections
- Interventions
- Cidofovir
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHerpes Simplex; HIV InfectionsInterventionCidofovirPhaseNot applicableRegistry statusCompletedThe Safety and Effectiveness of Cidofovir in the Treatment of Venereal Warts in HIV-Infected Patients
NCT00002327
Registered record
- Registry ID
- NCT00002327
- Conditions
- HIV Infections; Condyloma Acuminata
- Interventions
- Cidofovir
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 40
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIV Infections; Condyloma AcuminataInterventionCidofovirPhasePhase 1Registry statusCompletedA Study of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
NCT00002384
Registered record
- Registry ID
- NCT00002384
- Conditions
- Cytomegalovirus Retinitis; HIV Infections
- Interventions
- Cidofovir
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCytomegalovirus Retinitis; HIV InfectionsInterventionCidofovirPhaseNot applicableRegistry statusUnknownThe Safety and Effectiveness of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
NCT00002437
Registered record
- Registry ID
- NCT00002437
- Conditions
- Cytomegalovirus Retinitis; HIV Infections
- Interventions
- Cidofovir; Probenecid
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 48
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCytomegalovirus Retinitis; HIV InfectionsInterventionCidofovir; ProbenecidPhasePhase 2Registry statusCompletedCidofovir Instillation in Hematopoietic Stem Cell Transplant (HSCT) Recipients With Hemorrhagic Cystitis
NCT00956176
Registered record
- Registry ID
- NCT00956176
- Conditions
- Cystitis; Bladder Diseases
- Interventions
- Cidofovir
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Withdrawn
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 0
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCystitis; Bladder DiseasesInterventionCidofovirPhaseNot applicableRegistry statusWithdrawn