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AMR Drug RepurposingSmart Screeningresearch prototype

Cidofovir

FDA-approved product (solution, intravenous), marketed as Cidofovir, Vistide.

Registered studies
43
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Cidofovir
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cytomegalovirus Retinitis
  • Inborn error of immunity
  • Viral disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AB12

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Cidofovir, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA28.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli19.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis33.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

43registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cidofovir in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cidofovir with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Prolongation of a Clinical Study to Evaluate the Efficacy of an Aqueous Gel Containing 2% (w/w) of Cidofovir, Directly Applied on the Cervix Exhibiting High Grade Squamous Intraepithelial Lesions.

    NCT02976987 · start 2013-02

    Registered record
    Registry ID
    NCT02976987
    Conditions
    High Grade Cervical Epithelial Neoplasia (CIN2+)
    Interventions
    Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-02
    Completion
    2016-04
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh Grade Cervical Epithelial Neoplasia (CIN2+)
    InterventionCidofovir
    PhasePhase 2
    Registry statusCompleted

  • Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

    NCT01431326 · start 2011-11

    Registered record
    Registry ID
    NCT01431326
    Conditions
    Adenovirus; Anesthesia; Anxiety; Anxiolysis; Autism; Autistic Disorder; Bacterial Meningitis; Bacterial Septicemia; Benzodiazepine; Bipolar Disorder; Bone and Joint Infections; Central Nervous System Infections; Convulsions; Cytomegalovirus Retinitis; Early-onset Schizophrenia Spectrum Disorders; Epilepsy; General Anesthesia; Gynecologic Infections; Herpes Simplex Virus; Infantile Hemangioma; Infection; Inflammation; Inflammatory Conditions; Intra-abdominal Infections; Lower Respiratory Tract Infections; Migraines; Pain; Pneumonia; Schizophrenia; Sedation; Seizures; Skeletal Muscle Spasms; Skin and Skin-structure Infections; Treatment-resistant Schizophrenia; Urinary Tract Infections; Withdrawal; Sepsis; Gram-negative Infection; Bradycardia; Cardiac Arrest; Cardiac Arrhythmia; Staphylococcal Infections; Nosocomial Pneumonia; Neuromuscular Blockade; Methicillin Resistant Staphylococcus Aureus; Endocarditis; Neutropenia; Headache; Fibrinolytic Bleeding; Pulmonary Arterial Hypertension; C
    Interventions
    The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-11
    Completion
    2019-11
    Enrolment
    3,520

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenovirus; Anesthesia; Anxiety; Anxiolysis +47 more
    InterventionThe POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
    PhaseNot recorded
    Registry statusCompleted

  • Cidofovir Versus Best Supportive Care for Hemorrhagic Cystitis

    NCT01295645 · start 2011-03-17

    Registered record
    Registry ID
    NCT01295645
    Conditions
    Transplantation Infection
    Interventions
    Cidofovir; No Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2011-03-17
    Completion
    2028-03-15
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTransplantation Infection
    InterventionCidofovir; No Cidofovir
    PhasePhase 2
    Registry statusActive not recruiting

  • Safety and Tolerability of Cidofovir Gel Applied on Cervix Squamous Lesions

    NCT00989443 · start 2010-05

    Registered record
    Registry ID
    NCT00989443
    Conditions
    Uterine Cervical Neoplasms; Cervix Intraepithelial Neoplasia
    Interventions
    Cidofovir gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-05
    Completion
    Not recorded
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUterine Cervical Neoplasms; Cervix Intraepithelial Neoplasia
    InterventionCidofovir gel
    PhasePhase 1
    Registry statusCompleted

  • Trial of Topical Cidofovir for the Prevention of Hair Growth

    NCT00948506 · start 2009-07

    Registered record
    Registry ID
    NCT00948506
    Conditions
    Prevention of Hair Growth
    Interventions
    1% topical cidofovir; 3% topical cidofovir; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-07
    Completion
    2011-05
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrevention of Hair Growth
    Intervention1% topical cidofovir; 3% topical cidofovir; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Comparative Bioavailability and Effect of Food on CMX001 in Healthy Volunteers

    NCT00780182 · start 2008-10

    Registered record
    Registry ID
    NCT00780182
    Conditions
    Healthy
    Interventions
    CMX001
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-10
    Completion
    2009-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCMX001
    PhasePhase 1
    Registry statusCompleted

  • Cidofovir in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer Who Are Receiving Chemotherapy and Radiation Therapy

    NCT00811408 · start 2008-04

    Registered record
    Registry ID
    NCT00811408
    Conditions
    Cervical Cancer; Precancerous Condition
    Interventions
    carboplatin; cidofovir; protein expression analysis; laboratory biomarker analysis; brachytherapy; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2008-04
    Completion
    Not recorded
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCervical Cancer; Precancerous Condition
    Interventioncarboplatin; cidofovir; protein expression analysis; laboratory biomarker analysis +2 more
    PhasePhase 1
    Registry statusUnknown

  • Modulation of the Expression of Papillomavirus (HPV) Oncoproteins to Major the Radiosensitivity: Trial Combining an Antiviral Agent VISTIDE and Radiochemotherapy in Cervical Cancers

    NCT02515877 · start 2008-01

    Registered record
    Registry ID
    NCT02515877
    Conditions
    Cervical Cancer
    Interventions
    External radiotherapy + curietherapy; Vistide; Carboplatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-01
    Completion
    2013-04
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCervical Cancer
    InterventionExternal radiotherapy + curietherapy; Vistide; Carboplatin
    PhasePhase 1
    Registry statusCompleted

  • Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus

    NCT00550589 · start 2007-09

    Registered record
    Registry ID
    NCT00550589
    Conditions
    Anal Cancer; Precancerous Condition
    Interventions
    cidofovir; DNA methylation analysis; gene expression analysis; polymerase chain reaction; biopsy; histopathologic examination
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-09
    Completion
    2010-02
    Enrolment
    33

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnal Cancer; Precancerous Condition
    Interventioncidofovir; DNA methylation analysis; gene expression analysis; polymerase chain reaction +2 more
    PhasePhase 2
    Registry statusCompleted

  • Cidofovir in Renal Transplant Recipients With BKVN

    NCT00138424 · start 2006-05

    Registered record
    Registry ID
    NCT00138424
    Conditions
    BK Virus (Nephropathy)
    Interventions
    Cidofovir; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2006-05
    Completion
    2011-04
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBK Virus (Nephropathy)
    InterventionCidofovir; Placebo
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration

    NCT01866397 · start 2002-03

    Registered record
    Registry ID
    NCT01866397
    Conditions
    Cytomegalovirus Retinitis; Acute Renal Failure
    Interventions
    Cidofovir pharmacokinetics
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2002-03
    Completion
    2002-03
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Retinitis; Acute Renal Failure
    InterventionCidofovir pharmacokinetics
    PhasePhase 4
    Registry statusCompleted

  • Use of Cidofovir for Recurrent Respiratory Papillomatosis

    NCT00205374 · start 1999-11

    Registered record
    Registry ID
    NCT00205374
    Conditions
    Recurrent Respiratory Papillomatosis
    Interventions
    Cidofovir; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    1999-11
    Completion
    2009-12
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecurrent Respiratory Papillomatosis
    InterventionCidofovir; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Studies of Ocular Complications of AIDS (SOCA)--Ganciclovir-Cidofovir CMV Retinitis Trial (GCCRT)

    NCT00000143 · start 1997-05

    Registered record
    Registry ID
    NCT00000143
    Conditions
    Cytomegalovirus Retinitis; HIV Infections
    Interventions
    Ganciclovir implant and oral ganciclovir; Cidofovir intravenous
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1997-05
    Completion
    2000-06
    Enrolment
    61

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Retinitis; HIV Infections
    InterventionGanciclovir implant and oral ganciclovir; Cidofovir intravenous
    PhasePhase 3
    Registry statusCompleted

  • Antiviral Therapy in Treating Patients With Kaposi's Sarcoma With or Without HIV Infection

    NCT00019240 · start 1996-11

    Registered record
    Registry ID
    NCT00019240
    Conditions
    Sarcoma
    Interventions
    cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1996-11
    Completion
    2004-04
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSarcoma
    Interventioncidofovir
    PhasePhase 2
    Registry statusCompleted

  • Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus Retinitis

    NCT00004794 · start 1995-03

    Registered record
    Registry ID
    NCT00004794
    Conditions
    Cytomegalovirus Retinitis; Acquired Immunodeficiency Syndrome
    Interventions
    cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1995-03
    Completion
    Not recorded
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Retinitis; Acquired Immunodeficiency Syndrome
    Interventioncidofovir
    PhasePhase 2
    Registry statusCompleted