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AMR Drug RepurposingSmart Screeningresearch prototype

Cidofovir

FDA-approved product (solution, intravenous), marketed as Cidofovir, Vistide.

Registered studies
43
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Cidofovir
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cytomegalovirus Retinitis
  • Inborn error of immunity
  • Viral disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AB12

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Cidofovir, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA28.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli19.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis33.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

43registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cidofovir in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cidofovir with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT

    NCT07387367 · start 2026-03-17

    Registered record
    Registry ID
    NCT07387367
    Conditions
    Adenovirus Infections
    Interventions
    cidofovir; Brincidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2026-03-17
    Completion
    2028-06-30
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenovirus Infections
    Interventioncidofovir; Brincidofovir
    PhasePhase 3
    Registry statusRecruiting

  • A Study of Maribavir in Chinese Adults With Cytomegalovirus (CMV) Infections

    NCT06439342 · start 2024-12-16

    Registered record
    Registry ID
    NCT06439342
    Conditions
    Cytomegalovirus (CMV)
    Interventions
    Maribavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2024-12-16
    Completion
    2026-12-31
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus (CMV)
    InterventionMaribavir
    PhasePhase 3
    Registry statusRecruiting

  • A Study of LIVTENCITY (Maribavir) in Adults With Cytomegalovirus (CMV) Infection After Transplantation in South Korea

    NCT06555432 · start 2024-11-14

    Registered record
    Registry ID
    NCT06555432
    Conditions
    Cytomegalovirus (CMV)
    Interventions
    LIVTENCITY
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2024-11-14
    Completion
    2028-10-01
    Enrolment
    168

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus (CMV)
    InterventionLIVTENCITY
    PhaseNot recorded
    Registry statusRecruiting

  • A Phase 2a Study of IV BCV in Subjects With Adenovirus Infection

    NCT04706923 · start 2021-08-16

    Registered record
    Registry ID
    NCT04706923
    Conditions
    Adenovirus Infections; Cytomegalovirus Infection
    Interventions
    BCV
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2021-08-16
    Completion
    2025-05-15
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenovirus Infections; Cytomegalovirus Infection
    InterventionBCV
    PhasePhase 2
    Registry statusCompleted

  • Clinical Trial for Evaluating the Efficacy and Safety of Electrocoagulation vs Topic Sinecatechins vs Topic Cidofovir Within the Treatment to High-grade Anal Intraepithelial Neoplasia in HIV Homosexual Males

    NCT04055142 · start 2020-09-18

    Registered record
    Registry ID
    NCT04055142
    Conditions
    High-grade Anal Intraepithelial Neoplasia
    Interventions
    electrocoagulation; cidofovir 1% topical ointment; sinecatechins 10% topical ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2020-09-18
    Completion
    2024-07-02
    Enrolment
    108

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh-grade Anal Intraepithelial Neoplasia
    Interventionelectrocoagulation; cidofovir 1% topical ointment; sinecatechins 10% topical ointment
    PhasePhase 3
    Registry statusCompleted

  • Open Label Study of IV Brincidofovir in Adult Transplant Recipients With Adenovirus Viremia

    NCT03532035 · start 2018-12-15

    Registered record
    Registry ID
    NCT03532035
    Conditions
    Adenovirus
    Interventions
    Brincidofovir; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2018-12-15
    Completion
    2019-05-10
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenovirus
    InterventionBrincidofovir; Standard of Care
    PhasePhase 2
    Registry statusWithdrawn

  • Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP)

    NCT03465280 · start 2018-04-01

    Registered record
    Registry ID
    NCT03465280
    Conditions
    Recurrent Respiratory Papillomatosis; Human Papilloma Virus
    Interventions
    Microdebrider; Cold-steel surgery (forceps); Carbon dioxide laser; Potassium titanyl phosphate (KTP) laser; Pulsed dye laser; Radiofrequency ablation; Monopolar suction diathermy; Plasma coagulation; Other; Adjuvant therapies
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2018-04-01
    Completion
    2022-08-31
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecurrent Respiratory Papillomatosis; Human Papilloma Virus
    InterventionMicrodebrider; Cold-steel surgery (forceps); Carbon dioxide laser; Potassium titanyl phosphate (KTP) laser +6 more
    PhaseNot recorded
    Registry statusUnknown

  • The AdAPT Trial; Adenovirus After Allogeneic Pediatric Transplantation

    NCT03339401 · start 2017-12-22

    Registered record
    Registry ID
    NCT03339401
    Conditions
    Adenovirus
    Interventions
    Standard of Care; Brincidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2017-12-22
    Completion
    2019-05-10
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenovirus
    InterventionStandard of Care; Brincidofovir
    PhasePhase 2
    Registry statusTerminated

  • Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Subjects

    NCT03073967 · start 2017-05-08

    Registered record
    Registry ID
    NCT03073967
    Conditions
    HSV Infection
    Interventions
    Pritelivir; Investigator's choice
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-05-08
    Completion
    2025-11-11
    Enrolment
    158

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHSV Infection
    InterventionPritelivir; Investigator's choice
    PhasePhase 3
    Registry statusCompleted

  • Efficacy and Safety Study of Maribavir Treatment Compared to Investigator-assigned Treatment in Transplant Recipients With Cytomegalovirus (CMV) Infections That Are Refractory or Resistant to Treatment With Ganciclovir, Valganciclovir, Foscarnet, or Cidofovir

    NCT02931539 · start 2016-12-22

    Registered record
    Registry ID
    NCT02931539
    Conditions
    Cytomegalovirus (CMV)
    Interventions
    Maribavir; Ganciclovir; Valganciclovir; Foscarnet; Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-12-22
    Completion
    2020-08-17
    Enrolment
    352

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus (CMV)
    InterventionMaribavir; Ganciclovir; Valganciclovir; Foscarnet +1 more
    PhasePhase 3
    Registry statusCompleted

  • Intralesional Cidofovir for the Treatment of Recalcitrant Warts in the Pediatric Immune-suppressed Population.

    NCT02567149 · start 2016-06

    Registered record
    Registry ID
    NCT02567149
    Conditions
    Warts
    Interventions
    Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2016-06
    Completion
    2016-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWarts
    InterventionCidofovir
    PhasePhase 2
    Registry statusWithdrawn

  • Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis

    NCT02555800 · start 2014-12

    Registered record
    Registry ID
    NCT02555800
    Conditions
    Recurrent Respiratory Papillomatosis
    Interventions
    Bevacizumab; Cidofovir; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2014-12
    Completion
    2017-06
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecurrent Respiratory Papillomatosis
    InterventionBevacizumab; Cidofovir; Placebo
    PhasePhase 2
    Registry statusUnknown

  • Intravesical Cidofovir for Hemorrhagic Cystitis

    NCT01816646 · start 2013-09

    Registered record
    Registry ID
    NCT01816646
    Conditions
    Blood And Marrow Transplantation
    Interventions
    Cidofovir; Probenecid
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-09
    Completion
    2016-12
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlood And Marrow Transplantation
    InterventionCidofovir; Probenecid
    PhasePhase 1
    Registry statusCompleted

  • A Prospective, With One Site, Open-label Not Controled Trial, for the Observation of Treatment With CIDOFOVIR 1%, 3 Nights Per Week, During 4 Weeks, of Anal Intraepithelial Neoplasia, High Level, in HIV+ Patients

    NCT01946009 · start 2013-09

    Registered record
    Registry ID
    NCT01946009
    Conditions
    HIV
    Interventions
    Cidofovir 1% cream's basis, 2gr, three times per week, during 4 weeks.
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-09
    Completion
    2014-09
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV
    InterventionCidofovir 1% cream's basis, 2gr, three times per week, during 4 weeks.
    PhaseNot applicable
    Registry statusCompleted

  • A Study of the Safety and Efficacy of CMX001 for the Prevention of CMV Infection in CMV-seropositive HCT Recipients

    NCT01769170 · start 2013-08

    Registered record
    Registry ID
    NCT01769170
    Conditions
    CMV
    Interventions
    Brincidofovir; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-08
    Completion
    2016-01
    Enrolment
    452

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCMV
    InterventionBrincidofovir; Placebo
    PhasePhase 3
    Registry statusCompleted