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AMR Drug RepurposingSmart Screeningresearch prototype

Cidofovir

FDA-approved product (solution, intravenous), marketed as Cidofovir, Vistide.

Registered studies
43
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Cidofovir
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cytomegalovirus Retinitis
  • Inborn error of immunity
  • Viral disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AB12

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Cidofovir, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA28.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli19.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis33.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

43registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cidofovir in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cidofovir with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Studies of the Ocular Complications of AIDS (SOCA)--HPMPC Peripheral CMV Retinitis Trial (HPCRT)

    NCT00000142 · start 1994-04

    Registered record
    Registry ID
    NCT00000142
    Conditions
    HIV Infections; CMV Cytomegalovirus Retinitis
    Interventions
    Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    1994-04
    Completion
    1996-02
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; CMV Cytomegalovirus Retinitis
    InterventionCidofovir
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol

    NCT00000799

    Registered record
    Registry ID
    NCT00000799
    Conditions
    Cytomegalovirus Retinitis; HIV Infections
    Interventions
    Cidofovir; Probenecid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1996-04
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Retinitis; HIV Infections
    InterventionCidofovir; Probenecid
    PhaseNot applicable
    Registry statusCompleted

  • A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease

    NCT00000881

    Registered record
    Registry ID
    NCT00000881
    Conditions
    Cytomegalovirus Infections; Cytomegalovirus Retinitis; HIV Infections
    Interventions
    Cidofovir; Probenecid
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Infections; Cytomegalovirus Retinitis; HIV Infections
    InterventionCidofovir; Probenecid
    PhasePhase 1
    Registry statusWithdrawn

  • Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis

    NCT00000894

    Registered record
    Registry ID
    NCT00000894
    Conditions
    Cytomegalovirus Retinitis; HIV Infections
    Interventions
    Cidofovir; Probenecid; Ganciclovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Retinitis; HIV Infections
    InterventionCidofovir; Probenecid; Ganciclovir
    PhasePhase 4
    Registry statusCompleted

  • A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients

    NCT00000945

    Registered record
    Registry ID
    NCT00000945
    Conditions
    HIV Infections; Leukoencephalopathy, Progressive Multifocal
    Interventions
    Cidofovir; Probenecid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2001-03
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Leukoencephalopathy, Progressive Multifocal
    InterventionCidofovir; Probenecid
    PhaseNot applicable
    Registry statusCompleted

  • Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)

    NCT00001126

    Registered record
    Registry ID
    NCT00001126
    Conditions
    Papilloma
    Interventions
    Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2005-11
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPapilloma
    InterventionCidofovir
    PhasePhase 1
    Registry statusCompleted

  • A Phase I/II Study of the Safety and Efficacy of Topical 1-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine Dihydrate (Cidofovir; HPMPC) in the Treatment of Refractory Mucocutaneous Herpes Simplex Disease in Patients With AIDS

    NCT00002116

    Registered record
    Registry ID
    NCT00002116
    Conditions
    Herpes Simplex; HIV Infections
    Interventions
    Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHerpes Simplex; HIV Infections
    InterventionCidofovir
    PhasePhase 1
    Registry statusCompleted

  • An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS

    NCT00002142

    Registered record
    Registry ID
    NCT00002142
    Conditions
    Cytomegalovirus Retinitis; HIV Infections
    Interventions
    Cidofovir; Probenecid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Retinitis; HIV Infections
    InterventionCidofovir; Probenecid
    PhaseNot applicable
    Registry statusCompleted

  • Cidofovir as a Treatment for Herpes Simplex in Patients With AIDS

    NCT00002181

    Registered record
    Registry ID
    NCT00002181
    Conditions
    Herpes Simplex; HIV Infections
    Interventions
    Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHerpes Simplex; HIV Infections
    InterventionCidofovir
    PhaseNot applicable
    Registry statusCompleted

  • The Safety and Effectiveness of Cidofovir in the Treatment of Venereal Warts in HIV-Infected Patients

    NCT00002327

    Registered record
    Registry ID
    NCT00002327
    Conditions
    HIV Infections; Condyloma Acuminata
    Interventions
    Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Condyloma Acuminata
    InterventionCidofovir
    PhasePhase 1
    Registry statusCompleted

  • A Study of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS

    NCT00002384

    Registered record
    Registry ID
    NCT00002384
    Conditions
    Cytomegalovirus Retinitis; HIV Infections
    Interventions
    Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Retinitis; HIV Infections
    InterventionCidofovir
    PhaseNot applicable
    Registry statusUnknown

  • The Safety and Effectiveness of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS

    NCT00002437

    Registered record
    Registry ID
    NCT00002437
    Conditions
    Cytomegalovirus Retinitis; HIV Infections
    Interventions
    Cidofovir; Probenecid
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Retinitis; HIV Infections
    InterventionCidofovir; Probenecid
    PhasePhase 2
    Registry statusCompleted

  • Cidofovir Instillation in Hematopoietic Stem Cell Transplant (HSCT) Recipients With Hemorrhagic Cystitis

    NCT00956176

    Registered record
    Registry ID
    NCT00956176
    Conditions
    Cystitis; Bladder Diseases
    Interventions
    Cidofovir
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystitis; Bladder Diseases
    InterventionCidofovir
    PhaseNot applicable
    Registry statusWithdrawn