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AMR Drug RepurposingSmart Screeningresearch prototype

Trandolapril

FDA-approved product (tablet, oral), marketed as Mavik, Trandolapril.

Registered studies
29
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Trandolapril
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Heart failure
  • Hypertension
  • Myocardial infarction
  • Ventricular Dysfunction, Left

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Ace inhibitors, plain
FDA pharmacologic class
Angiotensin Converting Enzyme Inhibitor FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA37.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli26.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae18.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis61.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

29registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Trandolapril in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Trandolapril with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone

    NCT00391846 · start 2006-10

    Registered record
    Registry ID
    NCT00391846
    Conditions
    Heart Failure; Ventricular Dysfunction, Left
    Interventions
    Captopril; Enalapril; Lisinopril; Ramipril; Trandolapril; Bisoprolol; Carvedilol; Metoprolol succinate; Candesartan; Valsartan; Eplerenone; Spironolactone; Diuretics; HF treatment according to Swedish guidelines; Blood samples; The Kansas City Cardiomyopathy Questionnaire (KCCQ)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-10
    Completion
    2009-01
    Enrolment
    252

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure; Ventricular Dysfunction, Left
    InterventionCaptopril; Enalapril; Lisinopril; Ramipril +12 more
    PhasePhase 4
    Registry statusCompleted

  • Bioequivalence Study of Trandolapril 4 mg Tablets of Dr. Reddy's Under Fasting Conditions

    NCT01164787 · start 2006-03

    Registered record
    Registry ID
    NCT01164787
    Conditions
    Healthy
    Interventions
    Trandolapril; Mavik
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-03
    Completion
    2006-05
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTrandolapril; Mavik
    PhasePhase 1
    Registry statusCompleted

  • Bioequivalence Study of Trandolapril 4 mg Tablets of Dr. Reddy's Under Fed Conditions

    NCT01164800 · start 2006-03

    Registered record
    Registry ID
    NCT01164800
    Conditions
    Healthy
    Interventions
    Trandolapril; Mavik
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-03
    Completion
    2006-05
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTrandolapril; Mavik
    PhasePhase 1
    Registry statusCompleted

  • Acute Haemodynamic Effects of Treatment With Angiotensin Converting Enzyme (ACE)-Inhibitors in Patients With Symptomatic Aortic Stenosis

    NCT00252317 · start 2005-11

    Registered record
    Registry ID
    NCT00252317
    Conditions
    Aortic Stenosis
    Interventions
    Captopril and Trandolapril; Captopril Test Dose and Trandolapril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2005-11
    Completion
    2008-10
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAortic Stenosis
    InterventionCaptopril and Trandolapril; Captopril Test Dose and Trandolapril
    PhasePhase 4
    Registry statusUnknown

  • Trandolapril 4 mg Tablet Under Non-Fasting Conditions

    NCT00840073 · start 2004-10

    Registered record
    Registry ID
    NCT00840073
    Conditions
    Healthy
    Interventions
    Trandolapril 4 mg Tablets; Mavik® 4 mg Tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-10
    Completion
    2004-11
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTrandolapril 4 mg Tablets; Mavik® 4 mg Tablets
    PhasePhase 1
    Registry statusCompleted

  • Trandolapril 4 mg Tablet Under Fasting Conditions

    NCT00840632 · start 2004-10

    Registered record
    Registry ID
    NCT00840632
    Conditions
    Healthy
    Interventions
    Trandolapril 4 mg Tablets; Mavik® 4 mg Tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-10
    Completion
    2004-11
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTrandolapril 4 mg Tablets; Mavik® 4 mg Tablets
    PhasePhase 1
    Registry statusCompleted

  • Russian Study of the Efficacy and Safety of Tarka in Patients With Hypertension

    NCT00235001 · start 2004-06

    Registered record
    Registry ID
    NCT00235001
    Conditions
    Hypertension
    Interventions
    trandolapril/verapamil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-06
    Completion
    Not recorded
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventiontrandolapril/verapamil
    PhasePhase 4
    Registry statusCompleted

  • Canadian Study of Trandolapril on Blood Pressure in Hypertensive Patients (TRAIL)

    NCT00233532 · start 2004-03

    Registered record
    Registry ID
    NCT00233532
    Conditions
    Hypertension
    Interventions
    Trandolapril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-03
    Completion
    Not recorded
    Enrolment
    2,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionTrandolapril
    PhasePhase 4
    Registry statusCompleted

  • Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR)

    NCT00234858 · start 2004-03

    Registered record
    Registry ID
    NCT00234858
    Conditions
    Hypertension; Metabolic Syndrome
    Interventions
    trandolapril/verapamil; (Hyzaar) losartan/hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-03
    Completion
    Not recorded
    Enrolment
    280

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Metabolic Syndrome
    Interventiontrandolapril/verapamil; (Hyzaar) losartan/hydrochlorothiazide
    PhasePhase 4
    Registry statusCompleted

  • Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM)

    NCT00234871 · start 2004-01

    Registered record
    Registry ID
    NCT00234871
    Conditions
    Hypertension; Diabetes; Proteinuria
    Interventions
    trandolapril/verapamil; Lotrel (amlodipine/benazepril)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-01
    Completion
    Not recorded
    Enrolment
    357

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Diabetes; Proteinuria
    Interventiontrandolapril/verapamil; Lotrel (amlodipine/benazepril)
    PhasePhase 4
    Registry statusCompleted

  • Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension

    NCT00684489 · start 2003-09

    Registered record
    Registry ID
    NCT00684489
    Conditions
    Hypertension
    Interventions
    clinical hypertension specialist-no specific med. Any anti-hypertension meds.; renin guided therapeutics-no specific med. Any anti-hypertensive med.
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-09
    Completion
    2005-09
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionclinical hypertension specialist-no specific med. Any anti-hypertension meds.; renin guided therapeutics-no specific med. Any anti-hypertensive med.
    PhaseNot applicable
    Registry statusCompleted

  • Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives

    NCT00679653 · start 2002-02

    Registered record
    Registry ID
    NCT00679653
    Conditions
    Obesity; Hypertension
    Interventions
    sibutramine; sibutramine; verapamil/trandolapril; metoprolol/HCT; felodipine/ramipril
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-02
    Completion
    Not recorded
    Enrolment
    171

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity; Hypertension
    Interventionsibutramine; sibutramine; verapamil/trandolapril; metoprolol/HCT +1 more
    PhasePhase 3
    Registry statusCompleted

  • INVEST: INternational VErapamil SR Trandolapril STudy

    NCT00133692 · start 1997-09

    Registered record
    Registry ID
    NCT00133692
    Conditions
    Hypertension; Coronary Artery Disease
    Interventions
    Verapamil SR/Trandolapril/Hydrochlorothiazide (HCTZ); Atenolol/HCTZ/Trandolapril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    1997-09
    Completion
    2003-02
    Enrolment
    22,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Coronary Artery Disease
    InterventionVerapamil SR/Trandolapril/Hydrochlorothiazide (HCTZ); Atenolol/HCTZ/Trandolapril
    PhasePhase 4
    Registry statusCompleted

  • A Study for Prevention of Kidney Disease in Diabetic Patients (BENEDICT)

    NCT00235014 · start 1997-03

    Registered record
    Registry ID
    NCT00235014
    Conditions
    Hypertension; Diabetes
    Interventions
    trandolapril; trandolapril/verapamil; placebo; verapamil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    1997-03
    Completion
    Not recorded
    Enrolment
    1,204

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Diabetes
    Interventiontrandolapril; trandolapril/verapamil; placebo; verapamil
    PhasePhase 4
    Registry statusCompleted