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AMR Drug RepurposingSmart Screeningresearch prototype

Triptorelin Pamoate

FDA-approved product (injectable, intramuscular), marketed as Trelstar, Triptodur Kit.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Triptorelin Pamoate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Central precocious puberty
  • Metastatic prostate cancer
  • Neoplasm
  • Precocious puberty
  • Prostate adenocarcinoma
  • Prostate carcinoma

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Gonadotropin releasing hormone analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA61.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis61.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Triptorelin Pamoate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triptorelin Pamoate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • IVF/ICSI Protocols in Poor Responders With Growth Hormone

    NCT01897324 · start 2013-07

    Registered record
    Registry ID
    NCT01897324
    Conditions
    Female Infertility Due to Diminished Ovarian Reserve
    Interventions
    Growth hormone (Norditropin, Novo nordisk)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-07
    Completion
    2015-01
    Enrolment
    287

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFemale Infertility Due to Diminished Ovarian Reserve
    InterventionGrowth hormone (Norditropin, Novo nordisk)
    PhasePhase 4
    Registry statusCompleted

  • Gonadotropin-releasing Hormone (GnRH) Downregulation Versus Oral Anticonception Prior to ART in Postoperative Endometriosis Patients

    NCT02400801 · start 2013-06

    Registered record
    Registry ID
    NCT02400801
    Conditions
    Endometriosis; Infertility
    Interventions
    triptorelin; ethinylestradiol + dienogest
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-06
    Completion
    2018-01-26
    Enrolment
    166

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometriosis; Infertility
    Interventiontriptorelin; ethinylestradiol + dienogest
    PhaseNot applicable
    Registry statusCompleted

  • Endometrial Injury and IVF Outcome Parameters in Patients With Failed IVF Cycles

    NCT01798862 · start 2013-03

    Registered record
    Registry ID
    NCT01798862
    Conditions
    Repeated Implantation Failures
    Interventions
    Endometrial injury by hysteroscopy or pipelle sampling; Proceed to COH directly
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2013-03
    Completion
    2016-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRepeated Implantation Failures
    InterventionEndometrial injury by hysteroscopy or pipelle sampling; Proceed to COH directly
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Final Oocyte Maturation Via Administration of GnRH Agonists Followed By Luteal Support With hCG

    NCT01638026 · start 2012-09

    Registered record
    Registry ID
    NCT01638026
    Conditions
    Infertility
    Interventions
    TRIPTORELIN ACETATE, hCG
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-09
    Completion
    2017-08
    Enrolment
    93

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionTRIPTORELIN ACETATE, hCG
    PhasePhase 4
    Registry statusCompleted

  • GP Extended Action Triptorelin

    NCT01673984 · start 2012-08

    Registered record
    Registry ID
    NCT01673984
    Conditions
    Prostate Cancer
    Interventions
    Decapeptyl® SR 22.5mg; Decapeptyl® SR 11.25mg; Prostap® 3 DCS 11.25mg; Zoladex® LA 10.8mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2012-08
    Completion
    2014-02
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionDecapeptyl® SR 22.5mg; Decapeptyl® SR 11.25mg; Prostap® 3 DCS 11.25mg; Zoladex® LA 10.8mg
    PhasePhase 4
    Registry statusTerminated

  • Corifollitropin Alfa Followed by hpHMG in a Long GnRH Agonist Protocol for the Treatment of Poor Ovarian Responders

    NCT01732094 · start 2012-07

    Registered record
    Registry ID
    NCT01732094
    Conditions
    Infertility; Poor Ovarian Response
    Interventions
    Triptorelin; Corifollitropin alfa 150μg; hpHMG
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-07
    Completion
    2013-05
    Enrolment
    57

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility; Poor Ovarian Response
    InterventionTriptorelin; Corifollitropin alfa 150μg; hpHMG
    PhasePhase 2
    Registry statusCompleted

  • Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty

    NCT01467882 · start 2012-04

    Registered record
    Registry ID
    NCT01467882
    Conditions
    Central Precocious Puberty
    Interventions
    Triptorelin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-04
    Completion
    2014-07
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Precocious Puberty
    InterventionTriptorelin
    PhasePhase 3
    Registry statusCompleted

  • The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis

    NCT01581359 · start 2012-03

    Registered record
    Registry ID
    NCT01581359
    Conditions
    Endometriosis; Infertility
    Interventions
    Triptorelin acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-03
    Completion
    2015-05
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometriosis; Infertility
    InterventionTriptorelin acetate
    PhasePhase 4
    Registry statusCompleted

  • Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer

    NCT01492972 · start 2012-01

    Registered record
    Registry ID
    NCT01492972
    Conditions
    Prostate Cancer
    Interventions
    Radiation; Androgen Suppression Therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2012-01
    Completion
    Not recorded
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionRadiation; Androgen Suppression Therapy
    PhasePhase 3
    Registry statusRecruiting

  • Addition of Prednisolone and Heparin in Patients Undergoing IVF With Failed IVF Cycles

    NCT01590173 · start 2012-01

    Registered record
    Registry ID
    NCT01590173
    Conditions
    Infertility
    Interventions
    Prednisolone and Heparin during COH for IVF; COH for IVF
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2012-01
    Completion
    2016-07
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionPrednisolone and Heparin during COH for IVF; COH for IVF
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients

    NCT01353846 · start 2011-05

    Registered record
    Registry ID
    NCT01353846
    Conditions
    Infertility
    Interventions
    observation natural cycle; Agonist GnRH; estradiol Valerate; progesterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-05
    Completion
    2012-11
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    Interventionobservation natural cycle; Agonist GnRH; estradiol Valerate; progesterone
    PhasePhase 4
    Registry statusUnknown

  • Randomized Crossover Trial to Assess the Tolerability of Gonadotropin Releasing Hormone (GnRH) Analogue Administration

    NCT01161563 · start 2010-07

    Registered record
    Registry ID
    NCT01161563
    Conditions
    Prostate Cancer
    Interventions
    Triptorelin pamoate; Leuprolide acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-07
    Completion
    2011-04
    Enrolment
    118

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionTriptorelin pamoate; Leuprolide acetate
    PhasePhase 4
    Registry statusCompleted

  • Effect of Triptorelin (Decapeptyl®) 22.5 mg on Two Biomarkers in Patients With Advanced Prostate Cancer

    NCT01020448 · start 2009-11

    Registered record
    Registry ID
    NCT01020448
    Conditions
    Prostate Cancer
    Interventions
    Triptorelin (Decapeptyl®)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-11
    Completion
    2013-06
    Enrolment
    339

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionTriptorelin (Decapeptyl®)
    PhasePhase 3
    Registry statusCompleted

  • Study of Bone Mineral Density in Women With Breast Cancer Treated With Triptorelin and Tamoxifen or Exemestane on Protocol IBCSG 25-02

    NCT00963417 · start 2009-08-03

    Registered record
    Registry ID
    NCT00963417
    Conditions
    Breast Cancer; Osteoporosis
    Interventions
    laboratory biomarker analysis; dual x-ray absorptiometry
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-08-03
    Completion
    2024-10-23
    Enrolment
    119

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer; Osteoporosis
    Interventionlaboratory biomarker analysis; dual x-ray absorptiometry
    PhaseNot applicable
    Registry statusCompleted

  • Maintenance Therapy of Levonorgestrel-releasing Intrauterine System (LNG-IUS) to Prevent the Recurrence of Symptomatic Endometriosis After Conservative Surgery

    NCT01125488 · start 2008-03

    Registered record
    Registry ID
    NCT01125488
    Conditions
    Endometriosis
    Interventions
    LNG-IUS; GnRH agonist (triptorelin)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2008-03
    Completion
    2010-09
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometriosis
    InterventionLNG-IUS; GnRH agonist (triptorelin)
    PhasePhase 3
    Registry statusUnknown