Cefprozil
FDA-approved product (tablet, oral), marketed as Cefprozil, Cefzil.
- Registered studies
- 16
- Lab records
- 5
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Bacterial disease
- Chronic bronchitis
- Infection
- Otitis media
- Pharyngitis
- Recurrent tonsillitis
- Sinusitis
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Second-generation cephalosporins
- FDA pharmacologic class
- Cephalosporin Antibacterial FDA label ↗
- Anti-infective classification
- Classified as an existing antimicrobial.WHO ATC J01DC10; FDA class Cephalosporin Antibacterial
Repurposing investigation
Cefprozil is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.
AI-predicted activity
AI prediction · nothing measured- MRSA98.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
- E. coli80.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
- K. pneumoniae87.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
- M. tuberculosis38.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
16registered studies name this medicine, for any condition. See them below.
Experimental
- MRSA: measured active in 2 of 2 lab records
- E. coli: measured active in 2 of 2 lab records
- K. pneumoniae: measured active in 1 of 1 lab record
Show the 5 laboratory records, with sources
Loading records…
“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Cefprozil with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- EfinaconazoleExisting use: Tinea, Tinea unguium60.5% AI-predicted activityagainst MRSA7 registered studies
- Trametinib Dimethyl SulfoxideExisting use: Cancer, Cutaneous melanoma, Glioblastoma multiforme and 5 more60.4% AI-predicted activityagainst MRSA16 registered studies
- Sorafenib TosylateExisting use: Chromophobe renal cell carcinoma, Clear cell renal carcinoma, Hepatocellular carcinoma and 5 more60.4% AI-predicted activityagainst MRSA50+ registered studies
- PaclitaxelExisting use: Breast cancer, Breast carcinoma, Breast neoplasm and 13 more60.2% AI-predicted activityagainst MRSA50+ registered studies
- AcalabrutinibExisting use: Cancer, Chronic lymphocytic leukemia, Mantle cell lymphoma and 1 more60.2% AI-predicted activityagainst MRSA50+ registered studies
- PalbociclibExisting use: Breast cancer, Breast carcinoma, Breast neoplasm and 3 more60.2% AI-predicted activityagainst MRSA50+ registered studies
- PralatrexateExisting use: Cancer, Mature T-cell and NK-cell non-Hodgkin lymphoma, Neoplasm and 2 more60.0% AI-predicted activityagainst MRSA44 registered studies
- Angiotensin Ii AcetateExisting use: Cardiovascular disease, Hypotension, Septic shock and 1 more60.0% AI-predicted activityagainst MRSA10 registered studies
- NilotinibExisting use: Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Chronic myelogenous leukemia60.0% AI-predicted activityagainst MRSA50+ registered studies
- SuvorexantExisting use: Insomnia60.0% AI-predicted activityagainst MRSA50+ registered studies
- Leuprolide AcetateExisting use: Central precocious puberty, Metastatic prostate cancer, Neoplasm and 4 more59.9% AI-predicted activityagainst MRSA50+ registered studies
- Prucalopride SuccinateExisting use: Constipation, Constipation disorder59.7% AI-predicted activityagainst MRSA7 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Cefprozil 500 mg Tablets Under Fed Conditions
NCT00840866 · start 2003-09
Registered record
- Registry ID
- NCT00840866
- Conditions
- Healthy
- Interventions
- cefprozil; Cefzil®
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2003-09
- Completion
- 2003-09
- Enrolment
- 39
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHealthyInterventioncefprozil; Cefzil®PhasePhase 1Registry statusCompleted