Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Lubiprostone

FDA-approved product (capsule, oral), marketed as Amitiza, Lubiprostone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Lubiprostone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Chronic pain
  • Constipation
  • Constipation disorder
  • Irritable bowel syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other drugs for constipation
FDA pharmacologic class
Chloride Channel Activator FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli28.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae31.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis24.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lubiprostone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lubiprostone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults

    NCT02481947 · start 2015-05

    Registered record
    Registry ID
    NCT02481947
    Conditions
    Chronic Idiopathic Constipation
    Interventions
    BLI400 Laxative; Lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-05
    Completion
    2015-11
    Enrolment
    459

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Idiopathic Constipation
    InterventionBLI400 Laxative; Lubiprostone
    PhasePhase 3
    Registry statusCompleted

  • Evaluation of the Efficacy and Safety of Lubiprostone in Adults With Mixed or Unsubtyped Irritable Bowel Syndrome

    NCT02544152 · start 2015-02

    Registered record
    Registry ID
    NCT02544152
    Conditions
    Irritable Bowel Syndrome
    Interventions
    Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2015-02
    Completion
    2016-12
    Enrolment
    71

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIrritable Bowel Syndrome
    InterventionLubiprostone; Placebo
    PhasePhase 2
    Registry statusTerminated

  • Lubiprostone for Children With Constipation

    NCT02138136 · start 2014-02-26

    Registered record
    Registry ID
    NCT02138136
    Conditions
    Constipation - Functional
    Interventions
    Lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-02-26
    Completion
    2017-05-01
    Enrolment
    419

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation - Functional
    InterventionLubiprostone
    PhasePhase 3
    Registry statusCompleted

  • Lubiprostone in Children With Functional Constipation

    NCT02042183 · start 2013-12-13

    Registered record
    Registry ID
    NCT02042183
    Conditions
    Constipation - Functional
    Interventions
    Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-12-13
    Completion
    2016-07-27
    Enrolment
    606

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation - Functional
    InterventionLubiprostone; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Pharmacodynamic, Pharmacokinetic, and Tolerability Study of a Liquid Form of Lubiprostone in Adult Subjects With Chronic Idiopathic Constipation

    NCT01993875 · start 2013-10

    Registered record
    Registry ID
    NCT01993875
    Conditions
    Chronic Idiopathic Constipation
    Interventions
    Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-10
    Completion
    2014-01
    Enrolment
    164

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Idiopathic Constipation
    InterventionLubiprostone; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Lubiprostone as a Modulator of Gut Microbial Translocation in HIV With Incomplete CD4 Recovery on Antiretroviral Therapy

    NCT01839734 · start 2013-06

    Registered record
    Registry ID
    NCT01839734
    Conditions
    HIV
    Interventions
    Lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-06
    Completion
    2016-02
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV
    InterventionLubiprostone
    PhasePhase 2
    Registry statusCompleted

  • Evaluation of Clinical Equivalence Between Two Lubiprostone Products in the Treatment of Chronic Idiopathic Constipation

    NCT01674530 · start 2012-10

    Registered record
    Registry ID
    NCT01674530
    Conditions
    Chronic Idiopathic Constipation
    Interventions
    Lubiprostone; Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-10
    Completion
    2014-03
    Enrolment
    909

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Idiopathic Constipation
    InterventionLubiprostone; Lubiprostone; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Lubiprostone Effect on Gastrointestinal Tract Transit Times Measured by Smartpill in Patients With Chronic Constipation

    NCT01469819 · start 2012-06

    Registered record
    Registry ID
    NCT01469819
    Conditions
    Chronic Idiopathic Constipation
    Interventions
    Lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2012-06
    Completion
    2015-02
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Idiopathic Constipation
    InterventionLubiprostone
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Lubiprostone and Mucus Secretion in Patients With Chronic Constipation

    NCT01447849 · start 2011-08

    Registered record
    Registry ID
    NCT01447849
    Conditions
    Constipation
    Interventions
    lubiprostone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2011-08
    Completion
    2012-11
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation
    Interventionlubiprostone; placebo
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Evaluation of Clinical Equivalence Between Two Lubiprostone Products

    NCT01372423 · start 2011-05

    Registered record
    Registry ID
    NCT01372423
    Conditions
    Chronic Idiopathic Constipation
    Interventions
    Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-05
    Completion
    2012-06
    Enrolment
    808

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Idiopathic Constipation
    InterventionLubiprostone; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation for Colonoscopy

    NCT01324284 · start 2011-03

    Registered record
    Registry ID
    NCT01324284
    Conditions
    Colorectal Carcinoma
    Interventions
    Lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-03
    Completion
    2011-06
    Enrolment
    442

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Carcinoma
    InterventionLubiprostone
    PhasePhase 3
    Registry statusCompleted

  • Opioid-induced Bowel Dysfunction (OBD) Pivotal Assessment of Lubiprostone (OPAL)

    NCT01298219 · start 2010-12

    Registered record
    Registry ID
    NCT01298219
    Conditions
    Opioid-induced Bowel Dysfunction
    Interventions
    Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-12
    Completion
    2011-11
    Enrolment
    439

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid-induced Bowel Dysfunction
    InterventionLubiprostone; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Effects of Lubiprostone on Gastrointestinal Transit & pH in Irritable Bowel Syndrome (IBS) With Constipation

    NCT01162863 · start 2010-11

    Registered record
    Registry ID
    NCT01162863
    Conditions
    Irritable Bowel Syndrome; Constipation
    Interventions
    Lubiprostone; Placebo; Smartpill wireless motility capsule
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-11
    Completion
    2012-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIrritable Bowel Syndrome; Constipation
    InterventionLubiprostone; Placebo; Smartpill wireless motility capsule
    PhaseNot applicable
    Registry statusCompleted

  • Lubiprostone in Patients With Multiple Sclerosis Associated Constipation

    NCT01236534 · start 2010-11

    Registered record
    Registry ID
    NCT01236534
    Conditions
    Multiple Sclerosis; Constipation
    Interventions
    Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-11
    Completion
    2012-04
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Sclerosis; Constipation
    InterventionLubiprostone; Placebo
    PhasePhase 4
    Registry statusCompleted

  • The Effectiveness of Lubiprostone in Constipated Diabetics

    NCT01170039 · start 2010-09

    Registered record
    Registry ID
    NCT01170039
    Conditions
    Constipation; Diabetes
    Interventions
    Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-09
    Completion
    2014-10
    Enrolment
    121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation; Diabetes
    InterventionLubiprostone; Placebo
    PhasePhase 4
    Registry statusCompleted