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AMR Drug RepurposingSmart Screeningresearch prototype

Lubiprostone

FDA-approved product (capsule, oral), marketed as Amitiza, Lubiprostone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Lubiprostone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Chronic pain
  • Constipation
  • Constipation disorder
  • Irritable bowel syndrome

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other drugs for constipation
FDA pharmacologic class
Chloride Channel Activator FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli28.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae31.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis24.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lubiprostone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lubiprostone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Intestinal Microecology in Chronic Constipation

    NCT00934479 · start 2010-04

    Registered record
    Registry ID
    NCT00934479
    Conditions
    Other Constipation; Irritable Bowel Syndrome
    Interventions
    Lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-04
    Completion
    2012-02
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOther Constipation; Irritable Bowel Syndrome
    InterventionLubiprostone
    PhasePhase 1
    Registry statusCompleted

  • A Trial Comparing Split-Dose Miralax With Amitiza Pretreatment Versus Dulcolax Pretreatment Versus Golytely for Bowel Cleansing Prior to Colonoscopy

    NCT00953017 · start 2009-07

    Registered record
    Registry ID
    NCT00953017
    Conditions
    Colonoscopy
    Interventions
    Miralax (PEG 3350); Amitiza (Lubiprostone); Dulcolax (Bisacodyl); Golytely (polyethylene glycol)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07
    Completion
    2010-05
    Enrolment
    425

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColonoscopy
    InterventionMiralax (PEG 3350); Amitiza (Lubiprostone); Dulcolax (Bisacodyl); Golytely (polyethylene glycol)
    PhasePhase 4
    Registry statusCompleted

  • Lubiprostone as a Treatment for Constipation in Parkinson's Disease

    NCT00669461 · start 2009-06

    Registered record
    Registry ID
    NCT00669461
    Conditions
    Constipation; Parkinson's Disease
    Interventions
    Lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2009-06
    Completion
    2010-09
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation; Parkinson's Disease
    InterventionLubiprostone
    PhaseNot applicable
    Registry statusTerminated

  • Effects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit

    NCT00844831 · start 2009-05

    Registered record
    Registry ID
    NCT00844831
    Conditions
    Constipation
    Interventions
    Lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-05
    Completion
    2011-05
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation
    InterventionLubiprostone
    PhasePhase 4
    Registry statusCompleted

  • Effect of Lubiprostone on Methanogenesis and Bowel Function in Chronic Constipation.

    NCT01190020 · start 2009-02

    Registered record
    Registry ID
    NCT01190020
    Conditions
    Chronic Constipation, Methanogenesis
    Interventions
    Lubiprostone; Lubiprostone Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-02
    Completion
    2012-03
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Constipation, Methanogenesis
    InterventionLubiprostone; Lubiprostone Control
    PhasePhase 1
    Registry statusCompleted

  • Short Term Safety and Efficacy of Lubiprostone in Adults With Cystic Fibrosis

    NCT00706004 · start 2008-07

    Registered record
    Registry ID
    NCT00706004
    Conditions
    Constipation; Cystic Fibrosis
    Interventions
    lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-07
    Completion
    2009-12
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation; Cystic Fibrosis
    Interventionlubiprostone
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Lubiprostone in Combination With Standard PEG Preparation

    NCT00689026 · start 2008-05

    Registered record
    Registry ID
    NCT00689026
    Conditions
    Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2
    Interventions
    Lubiprostone; Polyethylene glycol with electrolytes
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-05
    Completion
    2010-03
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus, Type 1; Diabetes Mellitus, Type 2
    InterventionLubiprostone; Polyethylene glycol with electrolytes
    PhaseNot applicable
    Registry statusTerminated

  • Randomized, Placebo-controlled Trial of Lubiprostone as a Preparation for Capsule Endoscopy

    NCT00746395 · start 2008-04

    Registered record
    Registry ID
    NCT00746395
    Conditions
    Inflammatory Bowel Disease
    Interventions
    Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-04
    Completion
    2008-09
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammatory Bowel Disease
    InterventionLubiprostone; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Amitiza® Plus GoLYTELY® (PEG) Versus Placebo Plus GoLYTELY® for Outpatient Colonoscopy Preparation

    NCT00645801 · start 2008-03

    Registered record
    Registry ID
    NCT00645801
    Conditions
    Colonoscopy
    Interventions
    lubiprostone (Amitiza); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-03
    Completion
    2011-07
    Enrolment
    158

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColonoscopy
    Interventionlubiprostone (Amitiza); Placebo
    PhasePhase 4
    Registry statusCompleted

  • Lubiprostone Effects on Visceral Pain Sensitivity

    NCT01166789 · start 2008-02

    Registered record
    Registry ID
    NCT01166789
    Conditions
    Irritable Bowel Syndrome
    Interventions
    Lubiprostone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-02
    Completion
    2010-08
    Enrolment
    62

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIrritable Bowel Syndrome
    InterventionLubiprostone; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Opioid-induced Bowel Dysfunction: Long-Term Assessment of Lubiprostone

    NCT00620061 · start 2007-12

    Registered record
    Registry ID
    NCT00620061
    Conditions
    Opioid-Induced Bowel Dysfunction
    Interventions
    Lubiprostone 24
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-12
    Completion
    2009-09
    Enrolment
    439

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid-Induced Bowel Dysfunction
    InterventionLubiprostone 24
    PhasePhase 3
    Registry statusCompleted

  • Effect of Lubiprostone on Nutritional Status and Pulmonary Function in Adults With Cystic Fibrosis

    NCT00577499 · start 2007-10

    Registered record
    Registry ID
    NCT00577499
    Conditions
    Cystic Fibrosis; Constipation; Nutrition
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2007-10
    Completion
    2009-06
    Enrolment
    7

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystic Fibrosis; Constipation; Nutrition
    InterventionNot recorded
    PhaseNot recorded
    Registry statusTerminated

  • Split Dose Golytely With Amitiza Pretreatment Versus Split Dose Golytely Plus Placebo in Outpatient Colonoscopy

    NCT00611442 · start 2007-10

    Registered record
    Registry ID
    NCT00611442
    Conditions
    Bowel Preparation for Colonoscopy
    Interventions
    lubiprostone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-10
    Completion
    2008-01
    Enrolment
    191

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBowel Preparation for Colonoscopy
    Interventionlubiprostone; placebo
    PhaseNot applicable
    Registry statusCompleted

  • Lubiprostone, Colonic Motility and Sensation

    NCT00953043 · start 2007-09

    Registered record
    Registry ID
    NCT00953043
    Conditions
    Healthy
    Interventions
    lubiprostone; Placebo; Bowel preparation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-09
    Completion
    2009-07
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionlubiprostone; Placebo; Bowel preparation
    PhasePhase 4
    Registry statusCompleted

  • Effects of Lubiprostone on Gastric Function in Patients With Chronic Idiopathic Constipation

    NCT01460225 · start 2007-09

    Registered record
    Registry ID
    NCT01460225
    Conditions
    Chronic Idiopathic Constipation
    Interventions
    lubiprostone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-09
    Completion
    2011-01
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Idiopathic Constipation
    Interventionlubiprostone
    PhasePhase 4
    Registry statusCompleted