Lubiprostone
FDA-approved product (capsule, oral), marketed as Amitiza, Lubiprostone.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Chronic pain
- Constipation
- Constipation disorder
- Irritable bowel syndrome
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Other drugs for constipation
- FDA pharmacologic class
- Chloride Channel Activator FDA label ↗
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA51.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli28.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae31.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis24.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Lubiprostone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- FurazolidoneExisting use: Other antiinfectives and antiseptics91.4% AI-predicted activityagainst M. tuberculosisLab records exist49 registered studies
- TriflupromazineExisting use: Psychosis90.6% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- ValdecoxibExisting use: Dysmenorrhea, Osteoarthritis, Rheumatic disease and 1 more88.6% AI-predicted activityagainst M. tuberculosisLab records exist31 registered studies
- CelecoxibExisting use: Ankylosing spondylitis, Cancer, Colorectal neoplasm and 15 more87.6% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Dorzolamide HydrochlorideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma86.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- MethazolamideExisting use: Glaucoma, Open-angle glaucoma85.6% AI-predicted activityagainst M. tuberculosisLab records exist11 registered studies
- AcetazolamideExisting use: Altitude sickness, Angle-closure glaucoma, Congestive heart failure and 5 more85.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Trifluoperazine HydrochlorideExisting use: Anxiety disorder, Mental or behavioural disorder, Psychosis and 1 more84.6% AI-predicted activityagainst M. tuberculosis1 registered study
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives84.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- NitrofurazoneExisting use: Eye infection, Leishmaniasis, Trypanosomiasis84.0% AI-predicted activityagainst M. tuberculosis8 registered studies
- BrinzolamideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma83.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- ZonisamideExisting use: Epilepsy, Focal-onset seizure, Partial epilepsy and 1 more82.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults
NCT02481947 · start 2015-05
Registered record
- Registry ID
- NCT02481947
- Conditions
- Chronic Idiopathic Constipation
- Interventions
- BLI400 Laxative; Lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2015-05
- Completion
- 2015-11
- Enrolment
- 459
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Idiopathic ConstipationInterventionBLI400 Laxative; LubiprostonePhasePhase 3Registry statusCompletedEvaluation of the Efficacy and Safety of Lubiprostone in Adults With Mixed or Unsubtyped Irritable Bowel Syndrome
NCT02544152 · start 2015-02
Registered record
- Registry ID
- NCT02544152
- Conditions
- Irritable Bowel Syndrome
- Interventions
- Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Terminated
- Start
- 2015-02
- Completion
- 2016-12
- Enrolment
- 71
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionIrritable Bowel SyndromeInterventionLubiprostone; PlaceboPhasePhase 2Registry statusTerminatedLubiprostone for Children With Constipation
NCT02138136 · start 2014-02-26
Registered record
- Registry ID
- NCT02138136
- Conditions
- Constipation - Functional
- Interventions
- Lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2014-02-26
- Completion
- 2017-05-01
- Enrolment
- 419
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionConstipation - FunctionalInterventionLubiprostonePhasePhase 3Registry statusCompletedLubiprostone in Children With Functional Constipation
NCT02042183 · start 2013-12-13
Registered record
- Registry ID
- NCT02042183
- Conditions
- Constipation - Functional
- Interventions
- Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2013-12-13
- Completion
- 2016-07-27
- Enrolment
- 606
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionConstipation - FunctionalInterventionLubiprostone; PlaceboPhasePhase 3Registry statusCompletedPharmacodynamic, Pharmacokinetic, and Tolerability Study of a Liquid Form of Lubiprostone in Adult Subjects With Chronic Idiopathic Constipation
NCT01993875 · start 2013-10
Registered record
- Registry ID
- NCT01993875
- Conditions
- Chronic Idiopathic Constipation
- Interventions
- Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2013-10
- Completion
- 2014-01
- Enrolment
- 164
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Idiopathic ConstipationInterventionLubiprostone; PlaceboPhasePhase 3Registry statusCompletedLubiprostone as a Modulator of Gut Microbial Translocation in HIV With Incomplete CD4 Recovery on Antiretroviral Therapy
NCT01839734 · start 2013-06
Registered record
- Registry ID
- NCT01839734
- Conditions
- HIV
- Interventions
- Lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2013-06
- Completion
- 2016-02
- Enrolment
- 20
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHIVInterventionLubiprostonePhasePhase 2Registry statusCompletedEvaluation of Clinical Equivalence Between Two Lubiprostone Products in the Treatment of Chronic Idiopathic Constipation
NCT01674530 · start 2012-10
Registered record
- Registry ID
- NCT01674530
- Conditions
- Chronic Idiopathic Constipation
- Interventions
- Lubiprostone; Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2012-10
- Completion
- 2014-03
- Enrolment
- 909
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Idiopathic ConstipationInterventionLubiprostone; Lubiprostone; PlaceboPhasePhase 3Registry statusCompletedLubiprostone Effect on Gastrointestinal Tract Transit Times Measured by Smartpill in Patients With Chronic Constipation
NCT01469819 · start 2012-06
Registered record
- Registry ID
- NCT01469819
- Conditions
- Chronic Idiopathic Constipation
- Interventions
- Lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Phase 2 / Phase 3
- Registry status
- Completed
- Start
- 2012-06
- Completion
- 2015-02
- Enrolment
- 37
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Idiopathic ConstipationInterventionLubiprostonePhasePhase 2 / Phase 3Registry statusCompletedLubiprostone and Mucus Secretion in Patients With Chronic Constipation
NCT01447849 · start 2011-08
Registered record
- Registry ID
- NCT01447849
- Conditions
- Constipation
- Interventions
- lubiprostone; placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 2 / Phase 3
- Registry status
- Completed
- Start
- 2011-08
- Completion
- 2012-11
- Enrolment
- 40
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionConstipationInterventionlubiprostone; placeboPhasePhase 2 / Phase 3Registry statusCompletedEvaluation of Clinical Equivalence Between Two Lubiprostone Products
NCT01372423 · start 2011-05
Registered record
- Registry ID
- NCT01372423
- Conditions
- Chronic Idiopathic Constipation
- Interventions
- Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2011-05
- Completion
- 2012-06
- Enrolment
- 808
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Idiopathic ConstipationInterventionLubiprostone; PlaceboPhasePhase 3Registry statusCompletedComparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation for Colonoscopy
NCT01324284 · start 2011-03
Registered record
- Registry ID
- NCT01324284
- Conditions
- Colorectal Carcinoma
- Interventions
- Lubiprostone
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2011-03
- Completion
- 2011-06
- Enrolment
- 442
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CarcinomaInterventionLubiprostonePhasePhase 3Registry statusCompletedOpioid-induced Bowel Dysfunction (OBD) Pivotal Assessment of Lubiprostone (OPAL)
NCT01298219 · start 2010-12
Registered record
- Registry ID
- NCT01298219
- Conditions
- Opioid-induced Bowel Dysfunction
- Interventions
- Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2010-12
- Completion
- 2011-11
- Enrolment
- 439
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionOpioid-induced Bowel DysfunctionInterventionLubiprostone; PlaceboPhasePhase 3Registry statusCompletedEffects of Lubiprostone on Gastrointestinal Transit & pH in Irritable Bowel Syndrome (IBS) With Constipation
NCT01162863 · start 2010-11
Registered record
- Registry ID
- NCT01162863
- Conditions
- Irritable Bowel Syndrome; Constipation
- Interventions
- Lubiprostone; Placebo; Smartpill wireless motility capsule
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2010-11
- Completion
- 2012-12
- Enrolment
- 60
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionIrritable Bowel Syndrome; ConstipationInterventionLubiprostone; Placebo; Smartpill wireless motility capsulePhaseNot applicableRegistry statusCompletedLubiprostone in Patients With Multiple Sclerosis Associated Constipation
NCT01236534 · start 2010-11
Registered record
- Registry ID
- NCT01236534
- Conditions
- Multiple Sclerosis; Constipation
- Interventions
- Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2010-11
- Completion
- 2012-04
- Enrolment
- 21
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionMultiple Sclerosis; ConstipationInterventionLubiprostone; PlaceboPhasePhase 4Registry statusCompletedThe Effectiveness of Lubiprostone in Constipated Diabetics
NCT01170039 · start 2010-09
Registered record
- Registry ID
- NCT01170039
- Conditions
- Constipation; Diabetes
- Interventions
- Lubiprostone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2010-09
- Completion
- 2014-10
- Enrolment
- 121
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionConstipation; DiabetesInterventionLubiprostone; PlaceboPhasePhase 4Registry statusCompleted