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AMR Drug RepurposingSmart Screeningresearch prototype

Chloramphenicol

FDA-approved product (solution/drops, ophthalmic), marketed as Chloramphenicol, Chlorofair, Chloromycetin and 5 more.

Registered studies
23
Lab records
42
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Chloramphenicol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Bacterial disease
  • Eye infection

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Other antibiotics for topical use; Antiinfectives for treatment of acne; Antibiotics; Amphenicols; Antiinfectives
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC D10AF03; WHO ATC J01BA01; WHO ATC D06AX02; WHO ATC G01AA05; WHO ATC S01AA01

Repurposing investigation

Chloramphenicol is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA30.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli36.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae14.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis27.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

23registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 0 of 3 lab records
  • E. coli: measured active in 2 of 2 lab records
  • K. pneumoniae: measured active in 21 of 37 lab records
Open Chloramphenicol in ChEMBL Registered studies below
Show the 42 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Chloramphenicol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • The Efficacy of Permethrin 5%, Fusidic Acid 1% and Synthomycine 5% for Demodex - Blepharitis

    NCT03105505 · start 2017-04-28

    Registered record
    Registry ID
    NCT03105505
    Conditions
    Inflammation of the Eyelids
    Interventions
    Permethrin 5%; Synthomycine 5%; Fusidic Acid 1% M/R Eye Drops
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-04-28
    Completion
    2018-09
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammation of the Eyelids
    InterventionPermethrin 5%; Synthomycine 5%; Fusidic Acid 1% M/R Eye Drops
    PhasePhase 4
    Registry statusUnknown

  • Patients Response to Early Switch To Oral:Osteomyelitis Study

    NCT02099240 · start 2014-03-06

    Registered record
    Registry ID
    NCT02099240
    Conditions
    Osteomyelitis
    Interventions
    oral antibiotics; intravenous antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2014-03-06
    Completion
    2018-11-07
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventionoral antibiotics; intravenous antibiotics
    PhaseEarly phase 1
    Registry statusTerminated

  • Village Integrated Eye Workers Trial

    NCT01969786 · start 2014-02

    Registered record
    Registry ID
    NCT01969786
    Conditions
    Corneal Ulcer
    Interventions
    Corneal ulcer prevention program
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-02
    Completion
    2021-03
    Enrolment
    223,671

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCorneal Ulcer
    InterventionCorneal ulcer prevention program
    PhaseNot applicable
    Registry statusCompleted

  • Alcohol 20% for Separation of Pterygium and Comparison of Different Wound Closure Methods

    NCT00704977 · start 2008-06

    Registered record
    Registry ID
    NCT00704977
    Conditions
    Pterygium
    Interventions
    pterygium surgery using alcohol 20% for tissue separation and bare sclera as wound closure technique
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2008-06
    Completion
    2010-07
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPterygium
    Interventionpterygium surgery using alcohol 20% for tissue separation and bare sclera as wound closure technique
    PhaseNot applicable
    Registry statusUnknown

  • Effect of Thiamphenicol on EAAT2 and Other Biomarkers From Nasal Biopsied Tissue

    NCT00958503 · start 2007-07

    Registered record
    Registry ID
    NCT00958503
    Conditions
    Healthy
    Interventions
    Thiamphenicol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-07
    Completion
    2008-04
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionThiamphenicol; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Ceftriaxone Versus Chloramphenicol for Treatment of Severe Pneumonia in Children

    NCT00372541 · start 2006-09

    Registered record
    Registry ID
    NCT00372541
    Conditions
    Pneumonia
    Interventions
    ceftriaxone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2007-03
    Enrolment
    348

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    Interventionceftriaxone
    PhasePhase 3
    Registry statusCompleted

  • Antimicrobial Pulpotomy of Primary Molars

    NCT01010451 · start 2000-08

    Registered record
    Registry ID
    NCT01010451
    Conditions
    Inflammation; Necrosis
    Interventions
    Antimicrobial pulpotomy; Calcium hydroxide pulpectomy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2000-08
    Completion
    2006-08
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammation; Necrosis
    InterventionAntimicrobial pulpotomy; Calcium hydroxide pulpectomy
    PhasePhase 4
    Registry statusCompleted

  • The Role of Umbilical Cord Serum Therapy on Improvement of Corneal Epithelial Defect Following Diabetic Vitrectomy

    NCT01168375

    Registered record
    Registry ID
    NCT01168375
    Conditions
    Corneal Epithelial Defect
    Interventions
    conventional therapy plus umbilical cord serum eye drop; conventional therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCorneal Epithelial Defect
    Interventionconventional therapy plus umbilical cord serum eye drop; conventional therapy
    PhasePhase 1
    Registry statusUnknown