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AMR Drug RepurposingSmart Screeningresearch prototype

Prochlorperazine

FDA-approved product (suppository, rectal), marketed as Compazine, Compro, Prochlorperazine and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Prochlorperazine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anxiety disorder
  • Nausea and vomiting
  • Psychosis
  • Schizophrenia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Phenothiazines with piperazine structure
FDA pharmacologic class
Phenothiazine FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA39.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli42.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae13.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis74.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Prochlorperazine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Prochlorperazine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031)

    NCT01594749 · start 2012-09-24

    Registered record
    Registry ID
    NCT01594749
    Conditions
    Chemotherapy-Induced Nausea and Vomiting (CINV)
    Interventions
    Fosaprepitant dimeglumine; Fosaprepitant Placebo; Dexamethasone; Ondansetron; Dexamethasone Placebo; Ondansetron Placebo; Rescue Therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-09-24
    Completion
    2014-11-03
    Enrolment
    1,015

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChemotherapy-Induced Nausea and Vomiting (CINV)
    InterventionFosaprepitant dimeglumine; Fosaprepitant Placebo; Dexamethasone; Ondansetron +3 more
    PhasePhase 3
    Registry statusCompleted

  • Prochlorperazine Versus Prochlorperazine & Ketorolac in Treatment of Pediatric Migraine in the Emergency Department

    NCT01534806 · start 2012-01

    Registered record
    Registry ID
    NCT01534806
    Conditions
    Migraine
    Interventions
    Ketorolac; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2012-01
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionKetorolac; Placebo
    PhasePhase 4
    Registry statusWithdrawn

  • Emesis Control Study in Non-Hodgkin Lymphoma Patients Receiving R-CHOP

    NCT01843868 · start 2012-01

    Registered record
    Registry ID
    NCT01843868
    Conditions
    Lymphoma, Non-Hodgkin
    Interventions
    Standard anti-emetics in conjunction with R-CHOP
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2012-01
    Completion
    2015-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma, Non-Hodgkin
    InterventionStandard anti-emetics in conjunction with R-CHOP
    PhaseNot applicable
    Registry statusWithdrawn

  • Sunitinib or Cediranib for Alveolar Soft Part Sarcoma

    NCT01391962 · start 2011-07-18

    Registered record
    Registry ID
    NCT01391962
    Conditions
    Sarcoma, Alveolar Soft Part
    Interventions
    Cediranib; Sunitinib; Prochlorperazine; Promethazine; Benzodiazepine; Filgrastim; Sargramostim; Lomotil; Loperamide; Vitamin B6; Aquaphor; Acetaminophen; Levothyroxine; Warfarin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-07-18
    Completion
    2026-01-16
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSarcoma, Alveolar Soft Part
    InterventionCediranib; Sunitinib; Prochlorperazine; Promethazine +10 more
    PhasePhase 2
    Registry statusCompleted

  • Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine

    NCT01629329 · start 2010-11

    Registered record
    Registry ID
    NCT01629329
    Conditions
    Migraine Headaches
    Interventions
    Aspirin, Acetaminophen, Caffeine pills; Prochlorperazine 10mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2010-11
    Completion
    2014-07
    Enrolment
    93

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine Headaches
    InterventionAspirin, Acetaminophen, Caffeine pills; Prochlorperazine 10mg
    PhasePhase 4
    Registry statusTerminated

  • Trial of Best Supportive Care and Either Cisplatin or Paclitaxel to Treat Patients With Primary Ovarian Cancer, Primary Peritoneal Cancer or Fallopian Tube Cancer and Inoperable Malignant Bowel Obstruction

    NCT01083537 · start 2010-02

    Registered record
    Registry ID
    NCT01083537
    Conditions
    Ovarian Cancer; Peritoneal Cancer; Fallopian Tube Cancer; Bowel Obstruction
    Interventions
    Cisplatin; Paclitaxel
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2010-02
    Completion
    2012-06
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Cancer; Peritoneal Cancer; Fallopian Tube Cancer; Bowel Obstruction
    InterventionCisplatin; Paclitaxel
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • Ictal and Interictal Inflammatory Markers in Migraine

    NCT01138150 · start 2009-09

    Registered record
    Registry ID
    NCT01138150
    Conditions
    Migraine
    Interventions
    Treximet; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-09
    Completion
    2013-06
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionTreximet; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Staccato Prochlorperazine Thorough QT/QTc

    NCT00543062 · start 2007-10

    Registered record
    Registry ID
    NCT00543062
    Conditions
    Cardiotoxicity
    Interventions
    Inhaled placebo; Oral placebo; Inhaled prochlorperazine 5 mg; Inhaled prochlorperazine 10 mg; Oral moxifloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-10
    Completion
    2007-12
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiotoxicity
    InterventionInhaled placebo; Oral placebo; Inhaled prochlorperazine 5 mg; Inhaled prochlorperazine 10 mg +1 more
    PhasePhase 1
    Registry statusCompleted

  • Prochlorperazine vs Imitrex for Acute Migraine in the Emergency Department

    NCT00573599 · start 2007-02

    Registered record
    Registry ID
    NCT00573599
    Conditions
    Acute Migraine Headache
    Interventions
    prochlorperazine and benadryl IV; Imitrex SubQ, saline IV
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2007-02
    Completion
    2007-05
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Migraine Headache
    Interventionprochlorperazine and benadryl IV; Imitrex SubQ, saline IV
    PhaseNot applicable
    Registry statusWithdrawn

  • Prevention of Delayed Nausea A Phase III Double-Blind Placebo-Controlled Clinical Trial

    NCT00475085 · start 2006-12

    Registered record
    Registry ID
    NCT00475085
    Conditions
    Nausea
    Interventions
    aprepitant; dexamethasone; granisetron hydrochloride; palonosetron hydrochloride; prochlorperazine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-12
    Completion
    Not recorded
    Enrolment
    1,021

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNausea
    Interventionaprepitant; dexamethasone; granisetron hydrochloride; palonosetron hydrochloride +2 more
    PhasePhase 3
    Registry statusCompleted

  • Prochlorperazine vs Metoclopramide

    NCT00364806 · start 2006-08

    Registered record
    Registry ID
    NCT00364806
    Conditions
    Migraine
    Interventions
    Prochlorperazine; Metoclopramide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-08
    Completion
    2007-03
    Enrolment
    76

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionProchlorperazine; Metoclopramide
    PhasePhase 4
    Registry statusCompleted

  • Staccato Prochlorperazine in Migraine (Out Patient)

    NCT00422812 · start 2006-04

    Registered record
    Registry ID
    NCT00422812
    Conditions
    Migraine Headache; Aura
    Interventions
    Inhaled Placebo; Inhaled PCZ 5 mg; Inhaled PCZ 7.5 mg; Inhaled PCZ 10 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-04
    Completion
    2007-01
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine Headache; Aura
    InterventionInhaled Placebo; Inhaled PCZ 5 mg; Inhaled PCZ 7.5 mg; Inhaled PCZ 10 mg
    PhasePhase 2
    Registry statusCompleted

  • Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache

    NCT00274170 · start 2006-01

    Registered record
    Registry ID
    NCT00274170
    Conditions
    Migraine Headache
    Interventions
    Octreotide
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2006-01
    Completion
    2007-02
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine Headache
    InterventionOctreotide
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • Emend for Multiple-day Emetogenic Chemotherapy

    NCT00711555 · start 2005-11

    Registered record
    Registry ID
    NCT00711555
    Conditions
    Nausea; Vomiting
    Interventions
    aprepitant, ondansetron, dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-11
    Completion
    2009-01
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNausea; Vomiting
    Interventionaprepitant, ondansetron, dexamethasone
    PhasePhase 2
    Registry statusCompleted

  • Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department

    NCT00590317 · start 2005-03

    Registered record
    Registry ID
    NCT00590317
    Conditions
    Nausea and Vomiting
    Interventions
    Prochlorperazine; Ondansetron
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-03
    Completion
    2008-09
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNausea and Vomiting
    InterventionProchlorperazine; Ondansetron
    PhasePhase 2
    Registry statusCompleted