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AMR Drug RepurposingSmart Screeningresearch prototype

Prochlorperazine

FDA-approved product (suppository, rectal), marketed as Compazine, Compro, Prochlorperazine and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Prochlorperazine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anxiety disorder
  • Nausea and vomiting
  • Psychosis
  • Schizophrenia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Phenothiazines with piperazine structure
FDA pharmacologic class
Phenothiazine FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA39.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli42.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae13.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis74.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Prochlorperazine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Prochlorperazine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Treatment of Refractory Nausea and Vomiting in Patients With Breast Cancer

    NCT03367572 · start 2018-04-19

    Registered record
    Registry ID
    NCT03367572
    Conditions
    Breast Carcinoma
    Interventions
    Dexamethasone; Laboratory Biomarker Analysis; Netupitant/Palonosetron Hydrochloride; Olanzapine; Placebo; Prochlorperazine; Quality-of-Life Assessment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-04-19
    Completion
    2024-04-13
    Enrolment
    1,363

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Carcinoma
    InterventionDexamethasone; Laboratory Biomarker Analysis; Netupitant/Palonosetron Hydrochloride; Olanzapine +3 more
    PhasePhase 3
    Registry statusCompleted

  • A Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache

    NCT03472872 · start 2017-09-05

    Registered record
    Registry ID
    NCT03472872
    Conditions
    Headache
    Interventions
    Ketorolac; Acetaminophen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2017-09-05
    Completion
    2020-06-14
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeadache
    InterventionKetorolac; Acetaminophen
    PhasePhase 4
    Registry statusWithdrawn

  • Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy

    NCT03435003 · start 2017-08-28

    Registered record
    Registry ID
    NCT03435003
    Conditions
    Post-operative Nausea and Vomiting; Laparoscopic Sleeve Gastrectomy
    Interventions
    Aprepitant 80 mg Oral Capsule; scopolamine transdermal; Total intravenous anesthesia; Dexamethasone; Ondansetron; Reglan; Ondansetron; Compazine; Sugammadex; Propofol; dexmedetomidine; Fentanyl; Sevoflurane; Desflurane
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-08-28
    Completion
    2019-04-01
    Enrolment
    83

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-operative Nausea and Vomiting; Laparoscopic Sleeve Gastrectomy
    InterventionAprepitant 80 mg Oral Capsule; scopolamine transdermal; Total intravenous anesthesia; Dexamethasone +10 more
    PhasePhase 4
    Registry statusCompleted

  • Intravenous Fluids in Benign Headaches Trial

    NCT03185130 · start 2017-05-16

    Registered record
    Registry ID
    NCT03185130
    Conditions
    Headache
    Interventions
    Normal Saline 5mL; Normal Saline 20mL/kg; Prochlorperazine 0.15 mg/kg up to 10 mg IV; Diphenhydramine 1 mg/kg up to 50 mg IV
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-05-16
    Completion
    2019-05-15
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeadache
    InterventionNormal Saline 5mL; Normal Saline 20mL/kg; Prochlorperazine 0.15 mg/kg up to 10 mg IV; Diphenhydramine 1 mg/kg up to 50 mg IV
    PhasePhase 4
    Registry statusCompleted

  • E7 TCR T Cells for Human Papillomavirus-Associated Cancers

    NCT02858310 · start 2017-01-27

    Registered record
    Registry ID
    NCT02858310
    Conditions
    Papillomavirus Infections; Cervical Intraepithelial Neoplasia; Carcinoma In Situ; Vulvar Neoplasms; Vulvar Diseases
    Interventions
    E7 TCR cells; Aldesleukin; Fludarabine; Cyclophosphamide; EKG; Biopsy; Chest CT and MRI or PET; PFT; Granisetron; Ondansetron; Droperidol; Prochlorperazine; Diphenoxylate HCL; Atropine sulfate; Codeine sulfate; Loperamide; Indomethacin; Acetaminophen; Diphenhydramine HCL; Hydroxyzine HCL; Meperidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2017-01-27
    Completion
    2025-07-02
    Enrolment
    224

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPapillomavirus Infections; Cervical Intraepithelial Neoplasia; Carcinoma In Situ; Vulvar Neoplasms +1 more
    InterventionE7 TCR cells; Aldesleukin; Fludarabine; Cyclophosphamide +17 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine

    NCT02735343 · start 2016-08

    Registered record
    Registry ID
    NCT02735343
    Conditions
    Headache
    Interventions
    Compazine; Ketamine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2016-08
    Completion
    2017-05
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeadache
    InterventionCompazine; Ketamine
    PhasePhase 3
    Registry statusTerminated

  • Buccal Prochlorperazine Versus Intravenous Prochlorperazine for Migraine Headaches, a RCT

    NCT02779959 · start 2016-04

    Registered record
    Registry ID
    NCT02779959
    Conditions
    Migraine Disorders
    Interventions
    Prochlorperazine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2016-04
    Completion
    2018-04
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine Disorders
    InterventionProchlorperazine
    PhasePhase 3
    Registry statusUnknown

  • The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine

    NCT02657031 · start 2016-03-17

    Registered record
    Registry ID
    NCT02657031
    Conditions
    Headache
    Interventions
    Prochlorperazine; Ketamine; Diphenhydramine; Ondansetron; Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-03-17
    Completion
    2017-03-21
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeadache
    InterventionProchlorperazine; Ketamine; Diphenhydramine; Ondansetron +1 more
    PhasePhase 4
    Registry statusCompleted

  • Migraine Treatment in ED

    NCT02643719 · start 2015-12

    Registered record
    Registry ID
    NCT02643719
    Conditions
    Migraine
    Interventions
    Relaxation Therapy; Topiramate; Standard of Care; Abortive Medication (Naproxen and Sumatriptan)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2015-12
    Completion
    2017-10
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionRelaxation Therapy; Topiramate; Standard of Care; Abortive Medication (Naproxen and Sumatriptan)
    PhaseNot applicable
    Registry statusWithdrawn

  • Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)

    NCT02600741 · start 2015-07-24

    Registered record
    Registry ID
    NCT02600741
    Conditions
    Schizophrenia
    Interventions
    Caregiver psycho-education and skills training; Caregiver support available at the study site; Paliperidone palmitate; Chlorpromazine; Droperidol; Fluphenazine; Haloperidol; Loxapine; Perphenazine; Pimozide; Prochlorperazine; Thiothixene; Thioridazine; Trifluoperazine; Aripiprazole; Asenapine; Clozapine; Iloperidone; Olanzapine; Paliperidone; Quetiapine; Risperidone; Ziprasidone
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-07-24
    Completion
    2018-07-05
    Enrolment
    296

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionCaregiver psycho-education and skills training; Caregiver support available at the study site; Paliperidone palmitate; Chlorpromazine +19 more
    PhaseNot recorded
    Registry statusCompleted

  • Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine

    NCT02389829 · start 2015-03

    Registered record
    Registry ID
    NCT02389829
    Conditions
    Migraine
    Interventions
    Hydromorphone; Prochlorperazine; Diphenhydramine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-03
    Completion
    2016-10
    Enrolment
    127

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine
    InterventionHydromorphone; Prochlorperazine; Diphenhydramine
    PhasePhase 4
    Registry statusCompleted

  • T-cell Depleted Hematopoietic Stem Cell Boosts Without Conditioning for Poor Marrow Graft Function Following Allogeneic Hematopoietic Stem Cell Transplantation

    NCT02350777 · start 2015-01-21

    Registered record
    Registry ID
    NCT02350777
    Conditions
    Hematopoietic Stem Cell Transplant; Poor Marrow Graft Function
    Interventions
    Donor peripheral blood progenitor cells: stimulation, harvesting, isolation and T-cell depletion; CliniMACS Cell Selection System
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2015-01-21
    Completion
    2017-10-25
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHematopoietic Stem Cell Transplant; Poor Marrow Graft Function
    InterventionDonor peripheral blood progenitor cells: stimulation, harvesting, isolation and T-cell depletion; CliniMACS Cell Selection System
    PhasePhase 2
    Registry statusTerminated

  • IndoProCaf Effervescent Tablets Effectiveness in Acute Treatment of Migraine and/or Episodic Tension-type Headache and Patients' Satisfaction With the Treatment in Routine Clinical Practice

    NCT02115269 · start 2014-06

    Registered record
    Registry ID
    NCT02115269
    Conditions
    Headache Disorders, Primary; Migraine With Aura; Migraine Without Aura; Tension-Type Headache
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-06
    Completion
    2015-11
    Enrolment
    759

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeadache Disorders, Primary; Migraine With Aura; Migraine Without Aura; Tension-Type Headache
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Bupivacaine for Benign Headache in the ED

    NCT01785459 · start 2013-10

    Registered record
    Registry ID
    NCT01785459
    Conditions
    Benign Headache
    Interventions
    0.5% bupivacaine; Standard Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2013-10
    Completion
    2016-07
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Headache
    Intervention0.5% bupivacaine; Standard Care
    PhasePhase 2
    Registry statusTerminated

  • TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas

    NCT01851369 · start 2013-07-12

    Registered record
    Registry ID
    NCT01851369
    Conditions
    Lymphomas; Solid Tumors; NSCLC; Metastatic Colon Carcinoma; Granulosa Cell Ovarian Cancer
    Interventions
    TRC102; CT scan; Lomotil; Prochlorperazine; Metoclopramide; 5-HT3 antagonist; Aprepitant; Biopsy
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2013-07-12
    Completion
    2023-08-01
    Enrolment
    93

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphomas; Solid Tumors; NSCLC; Metastatic Colon Carcinoma +1 more
    InterventionTRC102; CT scan; Lomotil; Prochlorperazine +4 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted