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AMR Drug RepurposingSmart Screeningresearch prototype

Pyrimethamine

FDA-approved product (tablet, oral), marketed as Daraprim, Pyrimethamine.

Registered studies
50+
Lab records
9
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Pyrimethamine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Malaria
  • Toxoplasmosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Diaminopyrimidines
FDA pharmacologic class
Dihydrofolate Reductase Inhibitor Antimalarial FDA label ↗
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC P01BD01; WHO ATC P01BD51; FDA class Dihydrofolate Reductase Inhibitor Antimalarial

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA49.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli64.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae11.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis54.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • E. coli: measured active in 9 of 9 lab records
Open Pyrimethamine in ChEMBL Registered studies below
Show the 9 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Pyrimethamine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • IPT of Malaria With SP in Different Zones of Drug Resistance in Rwanda

    NCT00372632 · start 2005-12

    Registered record
    Registry ID
    NCT00372632
    Conditions
    Non HIV Infected Pregnant Women
    Interventions
    Sulfadoxine-Pyrimethamine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-12
    Completion
    2008-04
    Enrolment
    1,717

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon HIV Infected Pregnant Women
    InterventionSulfadoxine-Pyrimethamine; placebo
    PhasePhase 4
    Registry statusCompleted

  • To Compare Intravitreal Clindamycin & Dexamethasone With Classic Treatment of Toxoplasmic Retinochoroiditis

    NCT00372294 · start 2005-07

    Registered record
    Registry ID
    NCT00372294
    Conditions
    Chorioretinitis
    Interventions
    pyrimethamine-sulfadiazine + prednisolone; Clindamycin+Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2005-07
    Completion
    2008-11
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChorioretinitis
    Interventionpyrimethamine-sulfadiazine + prednisolone; Clindamycin+Dexamethasone
    PhasePhase 3
    Registry statusUnknown

  • ACT MALI: Treatment of Malaria Based on Combination Therapies

    NCT00452907 · start 2005-07

    Registered record
    Registry ID
    NCT00452907
    Conditions
    Malaria
    Interventions
    Artesunate; Artesunate + Sulfadoxine-Pyrimethamine; arthemether + lumefantrine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-07
    Completion
    2007-06
    Enrolment
    780

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionArtesunate; Artesunate + Sulfadoxine-Pyrimethamine; arthemether + lumefantrine
    PhasePhase 4
    Registry statusCompleted

  • Study on Preventing Anemia in Children in Ghana

    NCT00301054 · start 2005-06

    Registered record
    Registry ID
    NCT00301054
    Conditions
    Anaemia in Children
    Interventions
    Ferrous sulphate; Sulphadoxine-Pyrimethamine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-06
    Completion
    2006-04
    Enrolment
    872

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnaemia in Children
    InterventionFerrous sulphate; Sulphadoxine-Pyrimethamine
    PhaseNot applicable
    Registry statusCompleted

  • CQSP in Malawi: Chloroquine and Sulfadoxine-pyrimethamine Efficacy for the Treatment of Malaria in Malawi

    NCT00125489 · start 2005-05

    Registered record
    Registry ID
    NCT00125489
    Conditions
    Malaria; Plasmodium Falciparum Malaria
    Interventions
    chloroquine sulfate; sulfadoxine/pyrimethamine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-05
    Completion
    2005-12
    Enrolment
    210

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Plasmodium Falciparum Malaria
    Interventionchloroquine sulfate; sulfadoxine/pyrimethamine
    PhasePhase 4
    Registry statusCompleted

  • Long-Term Follow-up of Children for a 2-Year Period to Confirm the Safety and Immunogenicity of GSK 257049 Vaccine

    NCT00323622 · start 2005-04

    Registered record
    Registry ID
    NCT00323622
    Conditions
    Malaria
    Interventions
    GSK Biologicals' candidate Plasmodium falciparum malaria vaccine 257049; Engerix™-B; Hiberix®; Prevnar™; sulfadoxine-pyrimethamine; amodiaquine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-04
    Completion
    2007-05
    Enrolment
    1,737

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionGSK Biologicals' candidate Plasmodium falciparum malaria vaccine 257049; Engerix™-B; Hiberix®; Prevnar™ +2 more
    PhasePhase 2
    Registry statusCompleted

  • Preventing Malaria During Pregnancy in Epidemic-prone Areas.

    NCT00142207 · start 2004-01

    Registered record
    Registry ID
    NCT00142207
    Conditions
    Malaria, Falciparum
    Interventions
    Intermittent preventive treatment:sulphadoxine-pyrimethamine; Insecticide-treated mosquito bed net
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-01
    Completion
    2007-01
    Enrolment
    4,775

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria, Falciparum
    InterventionIntermittent preventive treatment:sulphadoxine-pyrimethamine; Insecticide-treated mosquito bed net
    PhasePhase 3
    Registry statusCompleted

  • Trial of the Effectiveness of AQ/AS, SP/AQ and SP/CQ for Uncomplicated Malaria in Gambian Children

    NCT00118807 · start 2003-08

    Registered record
    Registry ID
    NCT00118807
    Conditions
    Malaria
    Interventions
    Amodiaquine plus artesunate (AQ/AS); Sulfadoxine-pyrimethamine plus chloroquine (SP/CQ); Sulfadoxine-pyrimethamine plus amodiaquine (SP/AQ)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-08
    Completion
    2004-02
    Enrolment
    1,800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionAmodiaquine plus artesunate (AQ/AS); Sulfadoxine-pyrimethamine plus chloroquine (SP/CQ); Sulfadoxine-pyrimethamine plus amodiaquine (SP/AQ)
    PhasePhase 3
    Registry statusCompleted

  • Prevention of Intrauterine Growth Retardation in Burkina Faso: the Malaria Component

    NCT00680732 · start 2003-06

    Registered record
    Registry ID
    NCT00680732
    Conditions
    Malaria; Malaria in Pregnancy
    Interventions
    Multiple micronutrients supplements (MMS); Iron and folic acid (IFA); Chloroquine (CQ); Sulphadoxyne-pyrimethamine (SP)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-06
    Completion
    2006-10
    Enrolment
    1,370

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Malaria in Pregnancy
    InterventionMultiple micronutrients supplements (MMS); Iron and folic acid (IFA); Chloroquine (CQ); Sulphadoxyne-pyrimethamine (SP)
    PhasePhase 4
    Registry statusCompleted

  • Treatment of Malaria With Quinine Plus Sulfadoxine-Pyrimethamine

    NCT00167739 · start 2003-04

    Registered record
    Registry ID
    NCT00167739
    Conditions
    Malaria
    Interventions
    Quinine plus sulfadoxine-pyrimethamine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-04
    Completion
    2004-02
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionQuinine plus sulfadoxine-pyrimethamine
    PhasePhase 4
    Registry statusCompleted

  • Intermittent Antimalaria Treatment With SP in African Children

    NCT00168948 · start 2003-03

    Registered record
    Registry ID
    NCT00168948
    Conditions
    Malaria; Anemia
    Interventions
    Sulfadoxin (12.5) Pyrimethamine (250 mg)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2003-03
    Completion
    2005-08
    Enrolment
    1,200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Anemia
    InterventionSulfadoxin (12.5) Pyrimethamine (250 mg)
    PhasePhase 4
    Registry statusUnknown

  • Comparative Evaluation of the Safety and the Efficacy of 2 Antimalarials Depending on HIV Status

    NCT00304980 · start 2003-03

    Registered record
    Registry ID
    NCT00304980
    Conditions
    Plasmodium Falciparum Malaria
    Interventions
    ARTEMETHER + LUMEFANTRINE VS. SULFADOXINE + PYRIMETHAMINE
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2003-03
    Completion
    2005-04
    Enrolment
    3,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlasmodium Falciparum Malaria
    InterventionARTEMETHER + LUMEFANTRINE VS. SULFADOXINE + PYRIMETHAMINE
    PhaseNot applicable
    Registry statusTerminated

  • Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy

    NCT00164255 · start 2003-01

    Registered record
    Registry ID
    NCT00164255
    Conditions
    Malaria
    Interventions
    sulfadoxine/pyrimethamine; sulfadoxine/pyrimethamine plus artesunate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-01
    Completion
    2009-06
    Enrolment
    1,614

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    Interventionsulfadoxine/pyrimethamine; sulfadoxine/pyrimethamine plus artesunate
    PhasePhase 4
    Registry statusCompleted

  • A Randomised Efficacy Study of Combination Antimalarials to Treat Uncomplicated Malaria

    NCT00203736 · start 2003-01

    Registered record
    Registry ID
    NCT00203736
    Conditions
    Malaria
    Interventions
    Sulfadoxine-pyrimethamine; Artesunate plus sulfadoxine-pyrimethamine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-01
    Completion
    2003-10
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionSulfadoxine-pyrimethamine; Artesunate plus sulfadoxine-pyrimethamine
    PhaseNot applicable
    Registry statusCompleted

  • Intermittent Treatment With Sulfadoxine-pyrimethamine for Malaria Control in Infants

    NCT00206739 · start 2003-01

    Registered record
    Registry ID
    NCT00206739
    Conditions
    Malaria; Anemia
    Interventions
    Sulfadoxine (12.5 mg)/Pyrimethamine (250 mg)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-01
    Completion
    2005-09
    Enrolment
    1,070

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria; Anemia
    InterventionSulfadoxine (12.5 mg)/Pyrimethamine (250 mg)
    PhasePhase 4
    Registry statusCompleted