Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Mometasone Furoate

FDA-approved product (ointment, topical), marketed as Asmanex Hfa, Asmanex Twisthaler, Elocon and 4 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Mometasone Furoate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Allergic rhinitis
  • Asthma
  • Nasal Cavity Polyp
  • Nasal congestion
  • Nasal polyposis
  • Seasonal allergic rhinitis
  • Skin disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Corticosteroids; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Mometasone Furoate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Mometasone Furoate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Sensitivity of Pharmacokinetics to Differences in Particle Size Distribution of Suspension-based Nasal Sprays

    NCT02588326 · start 2018-09-21

    Registered record
    Registry ID
    NCT02588326
    Conditions
    Hypersensitivity
    Interventions
    Mometasone furoate drug formulation (MFF) 1; Mometasone furoate drug formulation (MFF) 2
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2018-09-21
    Completion
    2021-04-16
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypersensitivity
    InterventionMometasone furoate drug formulation (MFF) 1; Mometasone furoate drug formulation (MFF) 2
    PhasePhase 1
    Registry statusCompleted

  • Multi-disciplinary Diagnosis and Treatment Process and Evaluation System for Children With Sleep Disordered Breathing and Malocclusion

    NCT03451318 · start 2018-03-02

    Registered record
    Registry ID
    NCT03451318
    Conditions
    Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Malocclusion
    Interventions
    Mometasone Furoate Nasal Spray; tonsillar adenoidectomy; Maxillary expander plus Twin-Block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-03-02
    Completion
    2020-05-30
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Malocclusion
    InterventionMometasone Furoate Nasal Spray; tonsillar adenoidectomy; Maxillary expander plus Twin-Block
    PhaseNot applicable
    Registry statusUnknown

  • Asthma Research in Children and Adolescents

    NCT04480242 · start 2017-07-26

    Registered record
    Registry ID
    NCT04480242
    Conditions
    Persistent Asthma; Asthma in Children; Asthma Exacerbation
    Interventions
    Inhaled Corticosteroids (ICs); Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist (ICs/LABA); Other treatments; Inhaler device; Regularly monitoring of the Inhalation technique through mobile app
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2017-07-26
    Completion
    2030-12-31
    Enrolment
    525

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPersistent Asthma; Asthma in Children; Asthma Exacerbation
    InterventionInhaled Corticosteroids (ICs); Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist (ICs/LABA); Other treatments; Inhaler device +1 more
    PhaseNot recorded
    Registry statusActive not recruiting

  • Radiotherapy Related Skin Toxicity: Mepitel® vs. Standard Care in Patients With Locally Advanced Head-and-Neck Cancer

    NCT03047174 · start 2017-05-09

    Registered record
    Registry ID
    NCT03047174
    Conditions
    Head and Neck Neoplasms
    Interventions
    Mepitel® Film; Standard Care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-05-09
    Completion
    2019-07-16
    Enrolment
    57

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHead and Neck Neoplasms
    InterventionMepitel® Film; Standard Care
    PhaseNot applicable
    Registry statusCompleted

  • Study of QMF149 (150/80 µg) Compared With MF Twisthaler® (200 µg) in Patients With Asthma

    NCT02892344 · start 2017-01-16

    Registered record
    Registry ID
    NCT02892344
    Conditions
    Mild Asthma
    Interventions
    QMF149 150/80 μg; MF 200 μg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-01-16
    Completion
    2018-11-30
    Enrolment
    802

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMild Asthma
    InterventionQMF149 150/80 μg; MF 200 μg
    PhasePhase 3
    Registry statusCompleted

  • Response of the Airway in Sinusitis and Asthma

    NCT03011632 · start 2017-01

    Registered record
    Registry ID
    NCT03011632
    Conditions
    Sinusitis; Asthma
    Interventions
    Mometasone Nasal; placebo mometasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-01
    Completion
    2019-08
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis; Asthma
    InterventionMometasone Nasal; placebo mometasone
    PhasePhase 4
    Registry statusCompleted

  • Efficacy and Safety of Fixed Dose Combination GSP 301 Nasal Spray (NS) in the Treatment of Seasonal Allergic Rhinitis (SAR)

    NCT02631551 · start 2016-03

    Registered record
    Registry ID
    NCT02631551
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    GSP 301 NS; Olopatadine HCl NS; Mometasone furoate NS; GSP 301 Placebo NS
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-03
    Completion
    2016-07
    Enrolment
    1,180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    InterventionGSP 301 NS; Olopatadine HCl NS; Mometasone furoate NS; GSP 301 Placebo NS
    PhasePhase 3
    Registry statusCompleted

  • Study to Compare the Efficacy and Safety of QVM149 With QMF149 in Patients With Asthma

    NCT02571777 · start 2015-12-08

    Registered record
    Registry ID
    NCT02571777
    Conditions
    Asthma
    Interventions
    QVM149 150/50/160; QVM149 150/50/80; QMF149 150/320; QMF149 150/160; salmeterol/fluticasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-12-08
    Completion
    2019-06-14
    Enrolment
    3,092

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionQVM149 150/50/160; QVM149 150/50/80; QMF149 150/320; QMF149 150/160 +1 more
    PhasePhase 3
    Registry statusCompleted

  • The PIO (Propel In Office) III Study of In-office Placement of a Steroid-Eluting Implant Immediately Following Ethmoid Sinus Surgery

    NCT02687438 · start 2015-12

    Registered record
    Registry ID
    NCT02687438
    Conditions
    Chronic Sinusitis
    Interventions
    Steroid-releasing sinus implant; Post-op standard of care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-12
    Completion
    2016-02
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Sinusitis
    InterventionSteroid-releasing sinus implant; Post-op standard of care
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy and Steroid Sparing Potential Study of DGLA Cream in Patients With Moderate to Severe Atopic Dermatitis

    NCT03676036 · start 2015-06

    Registered record
    Registry ID
    NCT03676036
    Conditions
    Atopic Dermatitis
    Interventions
    DS107E; Vehicle
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-06
    Completion
    2018-07
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtopic Dermatitis
    InterventionDS107E; Vehicle
    PhasePhase 2
    Registry statusCompleted

  • S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps

    NCT02291549 · start 2014-12

    Registered record
    Registry ID
    NCT02291549
    Conditions
    Chronic Sinusitis; Nasal Polyposis
    Interventions
    S8 Sinus Implant; Mometasone furoate nasal spray; Sham
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-12
    Completion
    2016-10
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Sinusitis; Nasal Polyposis
    InterventionS8 Sinus Implant; Mometasone furoate nasal spray; Sham
    PhasePhase 3
    Registry statusCompleted

  • To Study GSP 301 in Patients With Seasonal Allergic Rhinitis

    NCT02318303 · start 2014-12

    Registered record
    Registry ID
    NCT02318303
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    GSP 301-1 NS (QD); GSP 301-2 NS (BID); GSP 301 Placebo NS; Olopatadine HCl-1 NS (QD); Olopatadine HCl-2 NS (BID); Mometasone Furoate-1 NS (QD); Mometasone Furoate-2 NS (BID)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-12
    Completion
    2015-02
    Enrolment
    1,111

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    InterventionGSP 301-1 NS (QD); GSP 301-2 NS (BID); GSP 301 Placebo NS; Olopatadine HCl-1 NS (QD) +3 more
    PhasePhase 2
    Registry statusCompleted

  • Steroids In Eosinophil Negative Asthma

    NCT02066298 · start 2014-07

    Registered record
    Registry ID
    NCT02066298
    Conditions
    Asthma
    Interventions
    Mometasone 220mcg BID; Tiotropium Respimat 5mcg QD; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-07
    Completion
    2018-05
    Enrolment
    295

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionMometasone 220mcg BID; Tiotropium Respimat 5mcg QD; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery

    NCT02110654 · start 2014-06

    Registered record
    Registry ID
    NCT02110654
    Conditions
    Sinusitis; Nasal Polyps; Asthma
    Interventions
    Montelukast; mometasone furoate nasal spray
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-06
    Completion
    2020-11-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis; Nasal Polyps; Asthma
    InterventionMontelukast; mometasone furoate nasal spray
    PhasePhase 4
    Registry statusCompleted

  • Improving Asthma Control in the Real World: A Systematic Approach to Improving Dulera Adherence

    NCT02045875 · start 2014-03-04

    Registered record
    Registry ID
    NCT02045875
    Conditions
    Asthma
    Interventions
    Dulera
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-03-04
    Completion
    2017-07-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionDulera
    PhasePhase 4
    Registry statusCompleted