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AMR Drug RepurposingSmart Screeningresearch prototype

Mometasone Furoate

FDA-approved product (ointment, topical), marketed as Asmanex Hfa, Asmanex Twisthaler, Elocon and 4 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Mometasone Furoate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Allergic rhinitis
  • Asthma
  • Nasal Cavity Polyp
  • Nasal congestion
  • Nasal polyposis
  • Seasonal allergic rhinitis
  • Skin disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids, potent (group iii); Corticosteroids, potent, other combinations; Corticosteroids; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Mometasone Furoate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Mometasone Furoate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Intranasal Steroids for the Treatment of Nocturnal Enuresis With Associated Obstructive Sleep Apnea

    NCT01861145 · start 2013-05

    Registered record
    Registry ID
    NCT01861145
    Conditions
    Enuresis; Obstructive Sleep Apnea; Sleep Disordered Breathing
    Interventions
    Bed Alarm; Nasonex
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2013-05
    Completion
    2016-06
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnuresis; Obstructive Sleep Apnea; Sleep Disordered Breathing
    InterventionBed Alarm; Nasonex
    PhasePhase 4
    Registry statusWithdrawn

  • Acute and Chronic Effects of Inhaled Steroids on Pulmonary Function in Persons With Spinal Cord Injury

    NCT01353599 · start 2011-08

    Registered record
    Registry ID
    NCT01353599
    Conditions
    Spinal Cord Injury
    Interventions
    Mometasone furoate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2011-08
    Completion
    Not recorded
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinal Cord Injury
    InterventionMometasone furoate
    PhasePhase 1
    Registry statusUnknown

  • A Clinical Evaluation of a Steroid-Coated Sinus Stent When Used Following Functional Endoscopic Sinus Surgery in Patients With Chronic Sinusitis

    NCT01253577 · start 2009-12

    Registered record
    Registry ID
    NCT01253577
    Conditions
    Chronic Sinusitis
    Interventions
    Sinus Stent with drug coating; Non Coated Sinus Stent
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-12
    Completion
    2010-10
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Sinusitis
    InterventionSinus Stent with drug coating; Non Coated Sinus Stent
    PhasePhase 3
    Registry statusCompleted

  • Nasonex (Mometasone Furoate Nasal Spray) in Adenoids Hypertrophy in Children (P04367)

    NCT01098071 · start 2008-08-01

    Registered record
    Registry ID
    NCT01098071
    Conditions
    Adenoids
    Interventions
    mometasone furoate nasal spray
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-08-01
    Completion
    2009-09-01
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdenoids
    Interventionmometasone furoate nasal spray
    PhasePhase 4
    Registry statusCompleted

  • Asthma Study Comparing Anti-Inflammatory Effects of 3 Doses of Mometasone Furoate/Formoterol Fumarate and Medium Dose Mometasone Furoate (Study P05122 AM1)(COMPLETED)

    NCT00635882 · start 2008-02

    Registered record
    Registry ID
    NCT00635882
    Conditions
    Asthma; Airway Inflammation
    Interventions
    mometasone furoate/formoterol 100/10 mcg; mometasone furoate/formoterol 200/10 mcg; mometasone furoate/formoterol 400/10 mcg; MF DPI 200 mcg; MF MDI 200 mcg; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-02
    Completion
    2009-06
    Enrolment
    93

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma; Airway Inflammation
    Interventionmometasone furoate/formoterol 100/10 mcg; mometasone furoate/formoterol 200/10 mcg; mometasone furoate/formoterol 400/10 mcg; MF DPI 200 mcg +2 more
    PhasePhase 2
    Registry statusCompleted

  • Safety and Tolerability of Indacaterol Maleate/Mometasone Furoate Delivered Via the Twisthaler® Device After 14 Days Treatment in Patients With Mild to Moderate Asthma

    NCT00605306 · start 2008-01

    Registered record
    Registry ID
    NCT00605306
    Conditions
    Asthma
    Interventions
    indacaterol maleate / mometasone furoate; placebo to indacaterol maleate/mometasone furoate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-01
    Completion
    2008-04
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    Interventionindacaterol maleate / mometasone furoate; placebo to indacaterol maleate/mometasone furoate
    PhasePhase 2
    Registry statusCompleted

  • Study of CRx-191 to Assess Activity in Plaque Psoriasis

    NCT00557739 · start 2007-11

    Registered record
    Registry ID
    NCT00557739
    Conditions
    Plaque Psoriasis
    Interventions
    mometasone furoate; nortriptyline HCl; Vehicle (placebo)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-11
    Completion
    2008-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlaque Psoriasis
    Interventionmometasone furoate; nortriptyline HCl; Vehicle (placebo)
    PhasePhase 2
    Registry statusCompleted

  • Assessing the Effects of a Nasal Corticosteroid on PMI-150 (Intranasal Ketamine)

    NCT00662883 · start 2007-11

    Registered record
    Registry ID
    NCT00662883
    Conditions
    Healthy
    Interventions
    PMI-150 (intranasal ketamine HCl); mometasone furoate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-11
    Completion
    2008-02
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionPMI-150 (intranasal ketamine HCl); mometasone furoate
    PhasePhase 1
    Registry statusCompleted

  • Mechanism(s) of Airflow Limitation During Exacerbation of Asthma

    NCT01225913 · start 2007-10

    Registered record
    Registry ID
    NCT01225913
    Conditions
    Asthma
    Interventions
    fluticasone/salmeterol in all asthmatics; budesonide/formoterol or fluticasone/salmeterol in all asthmatics
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2007-10
    Completion
    2027-06
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    Interventionfluticasone/salmeterol in all asthmatics; budesonide/formoterol or fluticasone/salmeterol in all asthmatics
    PhasePhase 4
    Registry statusRecruiting

  • Phase I Study of Topical CRx-191 in Normal Healthy Volunteers

    NCT00544687 · start 2007-09

    Registered record
    Registry ID
    NCT00544687
    Conditions
    Healthy
    Interventions
    CRx-191; mometasone furoate; nortriptyline HCl; Karison® Creme; Vehicle
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-09
    Completion
    2007-11
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCRx-191; mometasone furoate; nortriptyline HCl; Karison® Creme +1 more
    PhasePhase 1
    Registry statusCompleted

  • Study of Mometasone Furoate Nasal Spray and Oxymetazoline Nasal Spray Given Together Once A Day To Treat Seasonal Allergic Rhinitis (P04500)

    NCT00552110 · start 2007-07

    Registered record
    Registry ID
    NCT00552110
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    OXY combination: mometasone furoate nasal spray (MFNS) and oxymetazoline nasal spray (OXY); OXY combination: mometasone furoate nasal spray (MFNS) and oxymetazoline nasal spray (OXY); mometasone furoate nasal spray (MFNS) once daily; oxymetazoline nasal spray (OXY) twice daily; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-07
    Completion
    2008-02
    Enrolment
    707

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    InterventionOXY combination: mometasone furoate nasal spray (MFNS) and oxymetazoline nasal spray (OXY); OXY combination: mometasone furoate nasal spray (MFNS) and oxymetazoline nasal spray (OXY); mometasone furoate nasal spray (MFNS) once daily; oxymetazoline nasal spray (OXY) twice daily +1 more
    PhasePhase 2
    Registry statusCompleted

  • Placebo-Controlled Study of Mometasone Furoate Nasal Spray (MFNS) 200 mcg QD in the Treatment of Seasonal Allergic Rhinitis (Study P05106)(COMPLETED)

    NCT00468312 · start 2007-03

    Registered record
    Registry ID
    NCT00468312
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    Mometasone furoate nasal spray; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-03
    Completion
    2007-07
    Enrolment
    429

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    InterventionMometasone furoate nasal spray; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Effects of Mometasone Furoate/Formoterol Combination Versus Formoterol and Mometasone Furoate Alone in Chronic Obstructive Pulmonary Disease (COPD) (Study P04230AM4)(COMPLETED)

    NCT00383721 · start 2006-09

    Registered record
    Registry ID
    NCT00383721
    Conditions
    Chronic Obstructive Pulmonary Disease (COPD)
    Interventions
    Mometasone furoate/formoterol (MF/F) combination; Mometasone furoate/formoterol (MF/F) combination; Mometasone furoate MDI (MF MDI); Formoterol MDI; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2010-07
    Enrolment
    1,196

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease (COPD)
    InterventionMometasone furoate/formoterol (MF/F) combination; Mometasone furoate/formoterol (MF/F) combination; Mometasone furoate MDI (MF MDI); Formoterol MDI +1 more
    PhasePhase 3
    Registry statusCompleted

  • Study of Nasonex® in Improving Sleep Disturbances Related to Perennial Allergic Rhinitis (Study P04909)(TERMINATED)

    NCT00491374 · start 2006-09

    Registered record
    Registry ID
    NCT00491374
    Conditions
    Perennial Allergic Rhinitis
    Interventions
    Mometasone Furoate Nasal Spray; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2006-09
    Completion
    2007-10
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerennial Allergic Rhinitis
    InterventionMometasone Furoate Nasal Spray; Placebo
    PhasePhase 4
    Registry statusTerminated

  • Efficacy Study of the Combination Mometasone + Salicylic Acid in Patients With Psoriasis

    NCT01229085 · start 2006-09

    Registered record
    Registry ID
    NCT01229085
    Conditions
    Psoriasis
    Interventions
    memotasone + salicylic acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2007-10
    Enrolment
    71

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis
    Interventionmemotasone + salicylic acid
    PhasePhase 3
    Registry statusCompleted