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AMR Drug RepurposingSmart Screeningresearch prototype

Adefovir Dipivoxil

FDA-approved product (tablet, oral), marketed as Adefovir Dipivoxil, Hepsera.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Adefovir Dipivoxil
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Chronic hepatitis B virus infection
  • Hepatitis B virus infection
  • Viral disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Nucleoside and nucleotide reverse transcriptase inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AF08

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA28.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli41.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae31.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis49.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Adefovir Dipivoxil in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Adefovir Dipivoxil with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Entecavir Plus Adefovir in Lamivudine-Resistant Chronic Hepatitis B Patients Who Fail Lamivudine Plus Adefovir

    NCT01023217 · start 2009-11

    Registered record
    Registry ID
    NCT01023217
    Conditions
    Hepatitis B, Chronic
    Interventions
    Adefovir; Entecavir; Lamivudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-11
    Completion
    2012-09
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B, Chronic
    InterventionAdefovir; Entecavir; Lamivudine
    PhasePhase 4
    Registry statusCompleted

  • Hepatitis B Surface Antigen(HBsAg) Loss in Chronic Hepatitis B Patients With Low Viral Load

    NCT00973219 · start 2009-09

    Registered record
    Registry ID
    NCT00973219
    Conditions
    Chronic Hepatitis B
    Interventions
    Peg-Interferon alfa 2a + Adefovir dipivoxil, Peg-Interferon alfa 2a + Tenofovir disoproxil fumarate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2019-10
    Enrolment
    151

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    InterventionPeg-Interferon alfa 2a + Adefovir dipivoxil, Peg-Interferon alfa 2a + Tenofovir disoproxil fumarate
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Clevudine Plus Lamivudine for Lamivudine-resistant Chronic Hepatitis B Patients

    NCT00798460 · start 2008-12

    Registered record
    Registry ID
    NCT00798460
    Conditions
    Chronic Hepatitis B
    Interventions
    adefovir; clevudine; lamivudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2008-12
    Completion
    2010-11
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    Interventionadefovir; clevudine; lamivudine
    PhasePhase 4
    Registry statusTerminated

  • ADVANCE Study: A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) + Adefovir Dipivoxil in Patients With Hbe(-) Chronic Hepatitis B

    NCT00661076 · start 2008-08

    Registered record
    Registry ID
    NCT00661076
    Conditions
    Hepatitis B, Chronic
    Interventions
    adefovir dipivoxil; peginterferon alfa-2a [Pegasys]
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-08
    Completion
    2011-05
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B, Chronic
    Interventionadefovir dipivoxil; peginterferon alfa-2a [Pegasys]
    PhasePhase 3
    Registry statusCompleted

  • Efficacy Study of Prednisone Priming to Treat Asian Chronic Hepatitis B Patients

    NCT00715715 · start 2008-04

    Registered record
    Registry ID
    NCT00715715
    Conditions
    Chronic Hepatitis B
    Interventions
    Prednisone Priming
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2008-04
    Completion
    2011-02
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    InterventionPrednisone Priming
    PhaseNot applicable
    Registry statusWithdrawn

  • Prospective Exploratory Study to Describe Hepatitis B Virus (HBV) Kinetics During Treatment With Telbivudine

    NCT00640588 · start 2008-03

    Registered record
    Registry ID
    NCT00640588
    Conditions
    Hepatitis B, Chronic
    Interventions
    Telbivudine; oral adefovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2009-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B, Chronic
    InterventionTelbivudine; oral adefovir
    PhasePhase 3
    Registry statusCompleted

  • A Double-Blind Randomized Clinical Trial Comparing the Safety and Antiviral Activity of 48-week Clevudine and Adefovir Dipivoxil in HBeAg(-) Chronic Hepatitis B With Compensated Liver Function

    NCT00641082 · start 2008-02

    Registered record
    Registry ID
    NCT00641082
    Conditions
    HBeAg(-) Chronic Hepatitis B With Compensated Liver Function
    Interventions
    Clevudine; Adefovir dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-02
    Completion
    Not recorded
    Enrolment
    43

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHBeAg(-) Chronic Hepatitis B With Compensated Liver Function
    InterventionClevudine; Adefovir dipivoxil
    PhasePhase 4
    Registry statusCompleted

  • A Phase III Study in Post-operative HBV-related Hepatocellular Carcinoma

    NCT00455091 · start 2007-05

    Registered record
    Registry ID
    NCT00455091
    Conditions
    Hepatocellular Carcinoma
    Interventions
    Adefovir Dipivoxil and Lamivudine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2007-05
    Completion
    2018-04
    Enrolment
    117

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatocellular Carcinoma
    InterventionAdefovir Dipivoxil and Lamivudine
    PhaseNot recorded
    Registry statusTerminated

  • Study of Combination Therapy With LdT Plus Adefovir Versus Adefovir Alone

    NCT00376259 · start 2007-01

    Registered record
    Registry ID
    NCT00376259
    Conditions
    Hepatitis B
    Interventions
    telbivudine; adefovir dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2007-01
    Completion
    Not recorded
    Enrolment
    43

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B
    Interventiontelbivudine; adefovir dipivoxil
    PhasePhase 3
    Registry statusTerminated

  • PegIntron Versus Adefovir in the Treatment of Chronic Hepatitis B (CHB) e Antigen Positive Patients in Taiwan (P04498/MK-4031-278)

    NCT00371761 · start 2006-09

    Registered record
    Registry ID
    NCT00371761
    Conditions
    Hepatitis B, Chronic (CHB)
    Interventions
    Pegylated interferon alfa-2b (PegIntron); Adefovir dipivoxil (adefovir)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2009-02
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B, Chronic (CHB)
    InterventionPegylated interferon alfa-2b (PegIntron); Adefovir dipivoxil (adefovir)
    PhasePhase 3
    Registry statusCompleted

  • Adefovir Dipivoxil Tablets (10mg) In Chinese Subjects With HBe Antigen Negative Chronic Hepatitis B

    NCT00324961 · start 2006-01

    Registered record
    Registry ID
    NCT00324961
    Conditions
    Chronic Hepatitis B
    Interventions
    adefovir dipivoxil tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-01
    Completion
    2009-01
    Enrolment
    533

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    Interventionadefovir dipivoxil tablets
    PhasePhase 4
    Registry statusCompleted

  • Effect of Age on the Renal Clearance of Adefovir

    NCT00187746 · start 2005-08

    Registered record
    Registry ID
    NCT00187746
    Conditions
    Other Conditions That May Be A Focus of Clinical Attention
    Interventions
    Adefovir dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2005-08
    Completion
    2008-04
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOther Conditions That May Be A Focus of Clinical Attention
    InterventionAdefovir dipivoxil
    PhasePhase 4
    Registry statusWithdrawn

  • Study Comparing the Safety of Switching From Lamivudine to Adefovir Dipivoxil Versus Overlapping Lamivudine and Adefovir Before Adefovir Dipivoxil Monotherapy in Patients With Chronic Hepatitis B

    NCT00307242 · start 2005-06-17

    Registered record
    Registry ID
    NCT00307242
    Conditions
    Chronic Hepatitis B
    Interventions
    Adefovir Dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-06-17
    Completion
    2009-02-05
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    InterventionAdefovir Dipivoxil
    PhasePhase 4
    Registry statusCompleted

  • A Study to Compare Tenofovir Disoproxil Fumarate Versus Adefovir Dipivoxil for the Treatment of HBeAg-Positive Chronic Hepatitis B

    NCT00116805 · start 2005-06

    Registered record
    Registry ID
    NCT00116805
    Conditions
    Chronic Hepatitis B
    Interventions
    TDF; ADV; TDF placebo; ADV placebo; FTC/TDF
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-06
    Completion
    2016-01
    Enrolment
    266

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    InterventionTDF; ADV; TDF placebo; ADV placebo +1 more
    PhasePhase 3
    Registry statusCompleted

  • A Randomized Study Comparing Lamivudine Versus Adefovir Dipivoxil for Prevention of zHBV Reactivation in HBsAg Seropositive Patients Undergoing Cytotoxic Chemotherapy

    NCT00489151 · start 2005-06

    Registered record
    Registry ID
    NCT00489151
    Conditions
    Hepatitis B
    Interventions
    adefovir dipivoxil; lamivudine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2005-06
    Completion
    2007-12
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B
    Interventionadefovir dipivoxil; lamivudine
    PhaseNot applicable
    Registry statusUnknown