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AMR Drug RepurposingSmart Screeningresearch prototype

Adefovir Dipivoxil

FDA-approved product (tablet, oral), marketed as Adefovir Dipivoxil, Hepsera.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Adefovir Dipivoxil
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Chronic hepatitis B virus infection
  • Hepatitis B virus infection
  • Viral disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Nucleoside and nucleotide reverse transcriptase inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AF08

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA28.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli41.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae31.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis49.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Adefovir Dipivoxil in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Adefovir Dipivoxil with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Adefovir Dipivoxil For The Treatment Of Patients With Chronic Hepatitis B Related Advanced Fibrosis Or Cirrhosis

    NCT00347009 · start 2005-05

    Registered record
    Registry ID
    NCT00347009
    Conditions
    Hepatitis B, Chronic; Cirrhosis; Fibrosis; Chronic Hepatitis B
    Interventions
    adefovir dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-05
    Completion
    2009-09
    Enrolment
    155

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B, Chronic; Cirrhosis; Fibrosis; Chronic Hepatitis B
    Interventionadefovir dipivoxil
    PhasePhase 4
    Registry statusCompleted

  • An Open Label, Multi Centre Phase IV Study of Adefovir Dipivoxil in Korean Patients With Chronic Hepatitis B (CHB)

    NCT01205165 · start 2004-12-17

    Registered record
    Registry ID
    NCT01205165
    Conditions
    Hepatitis B, Chronic
    Interventions
    Adefor dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-12-17
    Completion
    2006-04-28
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B, Chronic
    InterventionAdefor dipivoxil
    PhasePhase 4
    Registry statusCompleted

  • Evaluation of cccDNA and Total HBV DNA Kinetics in Lymphocytes, Total Blood and Serum in Chronic Hepatitis B Patients Treated With Adefovir Dipivoxil and Peg Interferon Alpha 2a

    NCT00199732 · start 2004-12

    Registered record
    Registry ID
    NCT00199732
    Conditions
    Chronic Hepatitis B
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2004-12
    Completion
    2009-07
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Telbivudine Versus Adefovir Dipivoxil in Adults With HBegAg-Positive, Compensated Chronic Hepatitis B

    NCT00115245 · start 2004-11

    Registered record
    Registry ID
    NCT00115245
    Conditions
    Chronic Hepatitis B
    Interventions
    Telbivudine (LdT); Adefovir Dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-11
    Completion
    2006-08
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    InterventionTelbivudine (LdT); Adefovir Dipivoxil
    PhasePhase 3
    Registry statusCompleted

  • HEPSERA Post Marketing Surveillance

    NCT01329419 · start 2004-08

    Registered record
    Registry ID
    NCT01329419
    Conditions
    Hepatitis B
    Interventions
    adefovir dipivoxil
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2004-08
    Completion
    2010-02
    Enrolment
    4,393

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B
    Interventionadefovir dipivoxil
    PhaseNot recorded
    Registry statusCompleted

  • Safety and Efficacy of Adefovir Dipivoxil in Children and Adolescents With Chronic Hepatitis B

    NCT00095121 · start 2004-06

    Registered record
    Registry ID
    NCT00095121
    Conditions
    Chronic Hepatitis B
    Interventions
    Placebo (PLB); Adefovir Dipivoxil (ADV); Lamivudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-06
    Completion
    2010-04
    Enrolment
    173

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    InterventionPlacebo (PLB); Adefovir Dipivoxil (ADV); Lamivudine
    PhasePhase 3
    Registry statusCompleted

  • Safety and Efficacy Study of LB80380 in the Patients With Lamivudine-Refractory Chronic Hepatitis B

    NCT00895596 · start 2004-03

    Registered record
    Registry ID
    NCT00895596
    Conditions
    Chronic Hepatitis B
    Interventions
    LB80380
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2004-03
    Completion
    2007-12
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Hepatitis B
    InterventionLB80380
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Lamivudine and Adefovir to Treat Chronic Hepatitis B Infection in People With and Without HIV Infection

    NCT00023153 · start 2001-08

    Registered record
    Registry ID
    NCT00023153
    Conditions
    HIV Infections; Chronic Hepatitis B
    Interventions
    Adefovir Dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2001-08
    Completion
    2004-10
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Chronic Hepatitis B
    InterventionAdefovir Dipivoxil
    PhasePhase 3
    Registry statusCompleted

  • Lamivudine and Adefovir to Treat Chronic Hepatitis B

    NCT00023309 · start 2001-08

    Registered record
    Registry ID
    NCT00023309
    Conditions
    HBV (Hepatitis B Virus); Hepatitis B; Hepatitis
    Interventions
    Lamivudine and adefovir; Adefovir alone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2001-08
    Completion
    2013-08
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHBV (Hepatitis B Virus); Hepatitis B; Hepatitis
    InterventionLamivudine and adefovir; Adefovir alone
    PhasePhase 2
    Registry statusCompleted

  • Adefovir Dipivoxil to Treat Hepatitis B in HIV-Infected Patients

    NCT00013702 · start 2001-03

    Registered record
    Registry ID
    NCT00013702
    Conditions
    Hepatitis B; HIV Infection
    Interventions
    Adefovir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2001-03
    Completion
    2004-02
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B; HIV Infection
    InterventionAdefovir
    PhasePhase 2
    Registry statusCompleted

  • The Safety and Effectiveness of Adefovir Dipivoxil in the Treatment of HIV-Infected Patients

    NCT00001082 · start 1996-12

    Registered record
    Registry ID
    NCT00001082
    Conditions
    Cytomegalovirus Infections; HIV Infections
    Interventions
    Levocarnitine; Adefovir dipivoxil; Adefovir dipivoxil placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1996-12
    Completion
    1999-08
    Enrolment
    505

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytomegalovirus Infections; HIV Infections
    InterventionLevocarnitine; Adefovir dipivoxil; Adefovir dipivoxil placebo
    PhasePhase 3
    Registry statusCompleted

  • The Safety and Effectiveness of Adefovir Dipivoxil in HIV-Infected Children

    NCT00000843

    Registered record
    Registry ID
    NCT00000843
    Conditions
    HIV Infections
    Interventions
    Adefovir dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionAdefovir dipivoxil
    PhasePhase 1
    Registry statusCompleted

  • A Study of Several Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Used Indinavir

    NCT00000892

    Registered record
    Registry ID
    NCT00000892
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir; Delavirdine mesylate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1999-08
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil +2 more
    PhaseNot applicable
    Registry statusCompleted

  • A Study on Amprenavir in Combination With Other Anti-HIV Drugs in HIV-Positive Patients

    NCT00000912

    Registered record
    Registry ID
    NCT00000912
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Abacavir sulfate; Amprenavir; Nelfinavir mesylate; Efavirenz; Levocarnitine; Adefovir dipivoxil; Saquinavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2000-05
    Enrolment
    475

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Abacavir sulfate; Amprenavir; Nelfinavir mesylate +4 more
    PhasePhase 2
    Registry statusCompleted

  • A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Adefovir Dipivoxil When Added to Standard Antiretroviral Therapy for the Treatment of HIV-Infected Patients With CD4 Cell Counts >= 200/mm3

    NCT00002161

    Registered record
    Registry ID
    NCT00002161
    Conditions
    HIV Infections
    Interventions
    Adefovir dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionAdefovir dipivoxil
    PhaseNot applicable
    Registry statusCompleted