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AMR Drug RepurposingSmart Screeningresearch prototype

Dimercaprol

FDA-approved product (injectable, injection), marketed as Bal.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Dimercaprol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Dimercaprol. Its therapeutic class is shown instead.

WHO therapeutic group
Antidotes
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Dimercaprol, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA15.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli13.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis16.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Dimercaprol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Dimercaprol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Reusable Flexible Bronchoscopes Versus Single Use Bronchoscopes : a Satisfaction Survey

    NCT03392610 · start 2017-10-01

    Registered record
    Registry ID
    NCT03392610
    Conditions
    Bronchoscope Users
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2017-10-01
    Completion
    2019-06-30
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchoscope Users
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Microbiota and the Lung Cancer

    NCT03068663 · start 2017-05-23

    Registered record
    Registry ID
    NCT03068663
    Conditions
    Non Small Cell Lung Cancer
    Interventions
    Sampling
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2017-05-23
    Completion
    2029-10-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon Small Cell Lung Cancer
    InterventionSampling
    PhaseNot applicable
    Registry statusActive not recruiting

  • Changes in Alveolar Macrophage Function During Acute Lung Injury

    NCT02693912 · start 2016-09

    Registered record
    Registry ID
    NCT02693912
    Conditions
    Acute Lung Injury
    Interventions
    Bronchoscopy
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2016-09
    Completion
    2018-08
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lung Injury
    InterventionBronchoscopy
    PhaseNot recorded
    Registry statusUnknown

  • Change in Management Following Bronchoscopy in Hematopoietic Stem Cell Transplant Patients With Pulmonary Infiltrates

    NCT04998903 · start 2016-05-01

    Registered record
    Registry ID
    NCT04998903
    Conditions
    Stem Cell Transplant Complications; Pulmonary Complication
    Interventions
    Fiberoptic Bronchoscopy
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-05-01
    Completion
    2020-02-27
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStem Cell Transplant Complications; Pulmonary Complication
    InterventionFiberoptic Bronchoscopy
    PhaseNot recorded
    Registry statusCompleted

  • GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study

    NCT02525861 · start 2016-03-08

    Registered record
    Registry ID
    NCT02525861
    Conditions
    Alpha1-antitrypsin Deficiency
    Interventions
    GLASSIA
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-03-08
    Completion
    2020-07-29
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlpha1-antitrypsin Deficiency
    InterventionGLASSIA
    PhasePhase 3
    Registry statusCompleted

  • Effects of Permissive Hypercapnia During Lung Surgery on Inflammatory Biomarkers in Serum and Bronchoalveolar Lavage Fluid

    NCT07749456 · start 2015-06-01

    Registered record
    Registry ID
    NCT07749456
    Conditions
    Thoracic Surgery
    Interventions
    Allowed permissive hypercapnia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-06-01
    Completion
    2026-02-28
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThoracic Surgery
    InterventionAllowed permissive hypercapnia
    PhaseNot applicable
    Registry statusCompleted

  • Study of Different Etiologic Diagnostic Methods in Ventilator Associated Pneumonia (VAP)

    NCT02363023 · start 2015-06

    Registered record
    Registry ID
    NCT02363023
    Conditions
    Ventilator Associated Pneumonia
    Interventions
    Collect tracheal and pulmonary secretions
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2015-06
    Completion
    2016-06
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentilator Associated Pneumonia
    InterventionCollect tracheal and pulmonary secretions
    PhaseNot recorded
    Registry statusTerminated

  • Cardiopulmonary Effects of Bronchoalveolar Wash on Patients With Acute Respiratory Distress Syndrome

    NCT02818049 · start 2015-02-06

    Registered record
    Registry ID
    NCT02818049
    Conditions
    Bronchioalveolar Lavage
    Interventions
    Bronchoalveolar Lavage
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2015-02-06
    Completion
    2018-02-06
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchioalveolar Lavage
    InterventionBronchoalveolar Lavage
    PhaseNot applicable
    Registry statusTerminated

  • Lung Microbiome and Inflammation in Early COPD

    NCT02777879 · start 2014-05

    Registered record
    Registry ID
    NCT02777879
    Conditions
    Chronic Obstuctive Pulmonary Disease
    Interventions
    Bronchoscopy
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2014-05
    Completion
    2030-08
    Enrolment
    230

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstuctive Pulmonary Disease
    InterventionBronchoscopy
    PhaseNot recorded
    Registry statusRecruiting

  • Comparison of Characteristics of Bronchoalveolar Lavage Dusting and of Specific Questionnary Data in Healthy Volunteers and Patients Suffering From Sarcoidosis

    NCT02863406 · start 2014-02

    Registered record
    Registry ID
    NCT02863406
    Conditions
    Sarcoidosis
    Interventions
    Bronchoalveolar lavage
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-02
    Completion
    2015-07
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSarcoidosis
    InterventionBronchoalveolar lavage
    PhaseNot applicable
    Registry statusCompleted

  • Identification and Characterization of Bacteria in the Lungs of Children From 6 Months up to 6 Years Old, With Suspected Infection of the Lungs, in Spain.

    NCT02838407 · start 2013-09-23

    Registered record
    Registry ID
    NCT02838407
    Conditions
    Infections, Streptococcal
    Interventions
    BAL fluid sampling; Nasopharyngeal swab sampling
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-09-23
    Completion
    2015-09-23
    Enrolment
    197

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections, Streptococcal
    InterventionBAL fluid sampling; Nasopharyngeal swab sampling
    PhaseNot applicable
    Registry statusCompleted

  • Study on the Influence of Fluoroscopy in the Diagnosis of Peripheral Lung Lesions With Endobronchial Ultrasound Guidance

    NCT01863836 · start 2013-04

    Registered record
    Registry ID
    NCT01863836
    Conditions
    Peripheral Pulmonary Lesions
    Interventions
    Fluoroscopy; Radial EBUS-guided biopsy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-04
    Completion
    2015-04
    Enrolment
    133

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeripheral Pulmonary Lesions
    InterventionFluoroscopy; Radial EBUS-guided biopsy
    PhaseNot applicable
    Registry statusCompleted

  • Bronchoalveolar Lavage Lateral-Flow Device Test for Invasive Pulmonary Aspergillosis: a Multicenter Study

    NCT02058316 · start 2013-02

    Registered record
    Registry ID
    NCT02058316
    Conditions
    Invasive Pulmonary Aspergillosis
    Interventions
    Lateral Flow Device Test
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-02
    Completion
    2019-02
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Pulmonary Aspergillosis
    InterventionLateral Flow Device Test
    PhaseNot recorded
    Registry statusCompleted

  • Detecting Respiratory Viruses in Upper and Lower Respiratory Tract Samples

    NCT01597089 · start 2012-09-01

    Registered record
    Registry ID
    NCT01597089
    Conditions
    Respiratory Viruses
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2012-09-01
    Completion
    2018-05-01
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Viruses
    InterventionNot recorded
    PhaseNot recorded
    Registry statusTerminated

  • Diagnostic Study of Combined Biomnarker Testing in Bronchoalveolar Lavage Samples of Immunocompromised Patients

    NCT01695512 · start 2012-08

    Registered record
    Registry ID
    NCT01695512
    Conditions
    Invasive Aspergillosis; Acute Leukemia; Biomarkers; Stem Cell Transplantation
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2012-08
    Completion
    2020-12
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Aspergillosis; Acute Leukemia; Biomarkers; Stem Cell Transplantation
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown